Abstract
The aim of the present investigation was to study the role of Al2O3 in the Li2O–CaO–P2O5–SiO2 bioactive glass for improving the bioactivity and other physico-mechanical properties of glass. A comparative study on structural and physico-mechanical properties and bioactivity of glasses were reported. The structural properties of glasses were investigated by X-ray diffraction, Fourier transform infrared spectrometry, scanning electron microscopy and the bioactivity of the glasses was evaluated by in vitro test in simulated body fluid (SBF). Density, compressive strength, Vickers hardness and ultrasonic wave velocity of glass samples were measured to investigate physical and mechanical properties. Results indicated that partial molar replacement of Li2O by Al2O3 resulted in a significant increase in mechanical properties of glasses. In vitro studies of samples in SBF had shown that the pH of the solution increased after immersion of samples during the initial stage and then after reaching maxima it decreased with the increase in the immersion time. In vitro test in SBF indicated that the addition of Al2O3 up to 1.5 mol% resulted in an increase in bioactivity where as further addition of Al2O3 caused a decrease in bioactivity of the samples. The biocompatibility of these bioactive glass samples was studied using human osteoblast (MG-63) cell lines. The results obtained suggested that Li2O–CaO–Al2O3–P2O5–SiO2-based bioactive glasses containing alumina would be potential materials for biomedical applications.
Similar content being viewed by others
References
Hench L L 1991 J. Am. Ceram. Soc. 74 1487
Bohner M and Lemaitre J 2009 Biomaterials 30 2175
Clark A E and Hench L L 1976 J. Biomed. Mater. Res. 10 161
Hench L L 2006 J. Mater. Sci. Mater. Med. 17 967
Hench L L, Splinter R J, Allen W C and Greenlee T K 1971 J. Biomed. Mater. Res. Symp. 334 117
Kokubo T 1991 Biomaterials 12 155
LeGeros R Z 2002 Clin. Orthop. Relat. Res. 395 81
Cao W and Hench L L 1996 Ceram. Int. 22 493
Rahaman M N, Day D E, Bal B S, Fu Q, Jung S B and Bonewald L F 2011 Acta Biomater. 7 2355
Jung S B, Day D E, Day T, Stoecker W and Taylor P 2011 Wound Repair Regen. 30 19
Abou Neel E A, Pickup D M, Valappil S P, Newport R J and Knowles J C 2009 J. Mater. Chem. 19 690
Arstila H, Hupa L, Karlsson K H and Hupa M 2008 J. Non-Cryst. Solids 354 722
Shirtliff V J and Hench L L 2003 J. Mater. Sci. 38 4697
Li P, Zhang F and Kokubo T 1992 J. Mater. Sci.: Mater. Med. 3 452
Agathopoulos S, Tulaganov D U, Ventura J M G, Kannan S, Karakassides M A and Ferreira J M F 2006 Biomaterials 27 1832
Marti A, Dr. Robert Mathys Foundation, Bischmattstr. 12, CH-2544 Bettlach Injury—Int. J. Care Injured 01/2000; 31. DOI:10. 1016/S0020-1383(00)80021-2
El-Kheshen A, Khaliafa F A, Saad E A and Elwan R L 2008 Ceram. Int. 34 1667
Sitarz M, Bulat K and Szumera M 2010 J. Non-Cryst. Solids 356 224
Sitarz M 2010 Eur. J. Glass Sci. Tech. 51 179
Ohtsuki C, Kokubo T and Yamamuro T 1992 J. Mater. Sci.: Mater. Med. 3 119
Gross U and Strunz V 1985 J. Biomed. Mater. Res. 19 251
Clement-Lacroix P, Morvan F, Roman-Roman S, Vayssiere B and Belleville C 2005 Proc. Natl. Acad. Sci. 102 17406
Zamani A, Omrani R G and Nasab M M 2009 Bone 44 331
Kokubo K, Ito S, Huang Z T, Hayashi T, Sakka S, Kitsugi T and Yamamuro T 1990 J. Biomed. Mater. Res. 24 721
Kapusetti G, Misra N, Singh V, Srivastava S, Roy P, Dana K et al 2014, J. Mater. Chem. B. 2 3984
Kapusetti G, Misra N, Singh V, Kushwaha R K and Maiti P 2012 J. Biomed. Mater. Res. A 100 3363
Shannon R D 1976 Acta Crystallogr. Sect. A 32 751
Scholes S R 1975 Modern Glass Practice (Boston, MA: Cahners Books) 7th ed., p 375
Andersson O H and Sodergard A 1999 J. Non-Cryst. Solids 246 9
Branda F, Costantini A, Luciani G and Laudisio G 2001 J. Ther. Analy. Calori. 64 1017
Mirhadia B and Mehdikhanib B 2012 N. J. Glass Ceram. 2 1
Vallet-Reg M, Roma J, Padilla S, Doadrio J C and Gil F J 2005 J. Mater. Chem. 15 1353
Paul A 1990 Chemistry of Glasses (London: Chapman & Hall) 2nd ed., p 149–151
Varshneya A K 2006 Fundamentals of Inorganic Glasses (Sheffield, UK: Society of Glass Technology) p 129, 515–17
Paul A and Zaman M S 1978 J. Mater. Sci. 13 1499
Teixeira Z, Alves O L and Mazali I O 2007 J. Am. Ceram. Soc. 90 256
Filguei Ras M R, LaTorre G and Hench L L 1993 J. Biomed. Mater. Res. 27 1485
Belkebir A, Rocha J, Esculcas A P, Berthet P, Gilbert B and Gabelica Z 1999 Spectrosc. Acta 55 1323
Muller D, Berger G, Grunze I, Ludwig G, Hallas E and Haubenreisser U 1983 Phys. Chem. Glasses 24 37
Brow R K and Tallant D R 1997 J. Non-Cryst. Solids 222 396
Greenspan D C and Hench L L 1976 J. Biomed. Mater. Res. 10 503
Hayakawa S, Tsuru K, Ohtsuki C and Osaka A 1999 J. Am. Ceram. Soc. 82 2155
Kasuga T, Hosoi Y, Nogami M and Niinomi M 2001 J. Am. Ceram. Soc. 84 45
Filgueitras M R, LaTorre G and Hench L L 1993 J. Biomed. Mater. Res. 27 1485
Majhi M R, Pyare R and Singh S P 2012 J. Biomater. Tissue Eng. 2 1
Majhi M R, Pyare R and Singh S P 2011 J. Biomim. Biomater. Tissue Eng. 11 45
Majhi M R, Kumar R, Singh S P and Pyare R 2011 J. Biomim. Biomater. Tissue Eng. 12 1
de Groot K, Wolke J G C and Jansen J A 1998 Proc. Int. Mech. Eng. 212 137
Vitale Brovarone C, Verne E and Appendino P 2006 J. Mater. Sci.: Mater. Med. 17 1069
Beherei H H, Mohamed K R and El-Bassyouni G T 2009 Ceram. Int. 35 1991
Nakamura M, Mochizuki Y, Usami K, Itoh Y and Nozaki T 1984 Solid State Commun. 50 1079
Kusabiraki K 1986 J. Non-Cryst. Solids 79 208
Goh Y -F, Alshemary A Z, Akram M, Rafiq M Kadir A and Hussain R 2014 Ceram. Int. 40 729
Cerruti M, Greenspan D and Powers K 2005 Biomaterials 26 1665
Stoch A, Jastrzebski W, Brozek A, Trybalska B, Cichocinska M and Szarawara E 1999 J. Mol. Struct. 511–512 287
ElBatal H A, Azooz M A, Khalil E M A, Soltan Monem A and Hamdy Y M 2003 Mater. Chem. Phys. 80 599
Macon A L B, Kim T B, Valliant E M, Goetschius K, Brow R K, Day D E, Hoppe A, Boccaccini A R, Kim I Y, Ohtsuki C, Kokubo T, Osaka A, Vallet-Regı’ M, Arcos D, Fraile L, Salinas A J, Teixeira A V, Vueva Y, Almeida R M, Miola M, Vitale-Brovarone C, Verne E, Holand W and Jones J R 2015 J. Mater. Sci.: Mater. Med. 26 115
Kutbay I, Yilmaz B, Evis Z and Usta M 2014 Ceram. Int. 40 14817
Elliot J C ed 1994 Structure and Chemistry of the Apatites and Other Calcium Orthophosphates (Amsterdam: Elsevier Science)
Gisbon I R, Rehman I, Best S M and Bonfield W 2000 J. Mater. Sci. 12 799–804
Mohini G J, Krishnamacharyulu N, Baskaran G S, Rao P V and Veeraiah N 2013 Appl. Surf. Sci. 287 46
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
TRIPATHI, H., KUMAR, A.S. & SINGH, S.P. Preparation and characterization of Li2O–CaO–Al2O3–P2O5–SiO2 glasses as bioactive material. Bull Mater Sci 39, 365–376 (2016). https://doi.org/10.1007/s12034-016-1154-6
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12034-016-1154-6