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Insulin-like growth factor 1 gene polymorphism in women with breast cancer

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Abstract

Breast cancer is a disease of unknown etiology; however, the major risk factors are genetic alterations. Studies have demonstrated an association between insulin-like growth factor 1 (IGF-1) gene polymorphism and cell proliferation and reduced apoptosis, in addition to its role in breast cancer growth and aggressiveness. Two polymorphic variants of the IGF-1 gene are highlighted in association with breast cancer, rs6220 and rs7136446, although controversy exists as to this relationship. The current study included 137 women (68 breast cancer cases and 69 controls without breast cancer) who had 3 ml of peripheral blood drawn for the study of genomic DNA extracted from leukocytes using the genotyping technique by real-time polymerase chain reaction. The CC genotype (rs7136446) was present in 4 women (5.9%) from the case group and in 2 (3.0%) women from the control group (p = 0.67), while the GG genotype (rs6220) occurred in 8 (11.5%) women from the case group and in 5 (7.2%) women from the control group (p = 0.75). No statistically significant difference was observed between the CC genotype of variant rs7136446 in premenopausal case and control women (p = 0.31), thus as there was also no significant difference between case and control postmenopausal women (p = 1.00). Concerning the GG genotype of rs6220, it occurred in 6 (14.2%) premenopausal case and 4 (8%) control women (p = 0.71) and no difference was found in postmenopausal women (p = 1.00). In the current study, IGF-1 gene polymorphism of SNP variants rs6220 and rs7136446 had no statistically significant association with breast cancer, both in premenopausal and postmenopausal women.

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References

  1. Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015;136(5):E359–86.

    Article  CAS  PubMed  Google Scholar 

  2. Instituto Nacional Do Câncer (INCA) (2016). Estimating cancer in Brazil. http://www.inca.gov.br/estimativa/2016/.

  3. Pharoah PD, Day NE, Duffy S, Easton DF, Ponder BA. Family history and the risk of breast cancer: a systematic review and meta-analysis. Int J Cancer. 1997;71(5):800–9.

    Article  CAS  PubMed  Google Scholar 

  4. Mersch J, Jackson MA, Park M, Nebgen D, Peterson SK, Singletary C, et al. Cancers associated with BRCA1 and BRCA2 mutations other than breast and ovarian. Cancer. 2015;121(2):269–75.

    Article  CAS  PubMed  Google Scholar 

  5. Bonefeld K, Møller S. Insulin-like growth factor-I and the liver. Liver Int. 2011;31(7):911–9.

    Article  CAS  PubMed  Google Scholar 

  6. Brahmkhatri VP, Prasanna C, Atreya HS. Insulin-like growth factor system in cancer: novel targeted therapies. Biomed Res Int. 2015;2015:538019.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Philippou A, Maridaki M, Pneumaticos S, Koutsilieris M. The complexity of the IGF1 gene splicing, posttranslational modification and bioactivity. Mol Med. 2014;20:202–14.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Wagner K, Hemminki K, Försti A. The GH1/IGF-1 axis polymorphisms and their impact on breast cancer development. Breast Cancer Res Treat. 2007;104(3):233–48.

    Article  CAS  PubMed  Google Scholar 

  9. Chong YM, Subramanian A, Sharma AK, Mokbel K. The potential clinical applications of insulin-like growth factor-1 ligand in human breast cancer. Anticancer Res. 2007;27(3B):1617–24.

    CAS  PubMed  Google Scholar 

  10. López-Cima MF, González-Arriaga P, García-Castro L, Pascual T, Marrón MG, Puente XS, et al. Polymorphisms in XPC, XPD, XRCC1, and XRCC3 DNA repair genes and lung cancer risk in a population of northern Spain. BMC Cancer. 2007;7:162.

    Article  PubMed  Google Scholar 

  11. Tempfer CB, Hefler LA, Schneeberger C, Huber JC. How valid is single nucleotide polymorphism (SNP) diagnosis for the individual risk assessment of breast cancer? Gynecol Endocrinol. 2006;22(3):155–9.

    Article  CAS  PubMed  Google Scholar 

  12. Vottero A, Guzzetti C, Loche S. New aspects of the physiology of the GH-IGF-1 axis. Endocr Dev. 2013;24:96–105.

    CAS  PubMed  Google Scholar 

  13. Verheus M, McKay JD, Kaaks R, Canzian F, Biessy C, Johansson M, et al. Common genetic variation in the IGF-1 gene, serum IGF-I levels and breast density. Breast Cancer Res Treat. 2008;112(1):109–22.

    Article  CAS  PubMed  Google Scholar 

  14. Al-Zahrani A, Sandhu MS, Luben RN, Thompson D, Baynes C, Pooley KA. IGF1 and IGFBP3 tagging polymorphisms are associated with circulating levels of IGF1, IGFBP3 and risk of breast cancer. Hum Mol Genet. 2006;15(1):1–10.

    Article  CAS  PubMed  Google Scholar 

  15. Qian Y, Sun H, Lin K, Shi L, Shi L, Chu J. Distribution of CCR5-Delta32, CCR2-64I, SDF1-3’A, CX3CR1-249I, and CX3CR1-280M in Chinese populations. AIDS Res Hum Retrovir. 2008;24(11):1391–7.

    Article  CAS  PubMed  Google Scholar 

  16. Ferreira-Fernandes H, Santos AC, Motta FJ, Canalle R, Yoshioka FK, Burbano RR, et al. Prevalence of CCR5-Δ32 and CCR2-V64I polymorphisms in a mixed population from northeastern Brazil. Genet Mol Res. 2015;14(4):11710–8.

    Article  CAS  PubMed  Google Scholar 

  17. Hankinson SE, Willett WC, Colditz GA, Hunter DJ, Michaud DS, Deroo B, et al. Circulating concentrations of insulin-like growth factor-I and risk of breast cancer. Lancet. 1998;351(9113):1393–6.

    Article  CAS  PubMed  Google Scholar 

  18. Gu F, Schumacher FR, Canzian F, Allen NE, Albanes D, Berg CD, et al. Eighteen insulin-like growth factor pathway genes, circulating levels of IGF-I and its binding protein, and risk of prostate and breast cancer. Cancer Epidemiol Biomark Prev. 2010;19(11):2877–87.

    Article  CAS  Google Scholar 

  19. Diorio C, Brisson J, Bérubé S, Pollak M. Genetic polymorphisms involved in insulin-like growth factor (IGF) pathway in relation to mammographic breast density and IGF levels. Cancer Epidemiol Biomark Prev. 2008;17(4):880–8.

    Article  CAS  Google Scholar 

  20. Shi J, Aronson KJ, Grundy A, Kobayashi LC, Burstyn I, Schuetz JM, Lohrisch CA, et al. Polymorphisms of insulin-like growth factor 1 pathway genes and breast cancer risk. Front Oncol. 2016;6:136.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Batar B, Güven M, Bariş S, Celkan T, Yildiz I. DNA repair gene XPD and XRCC1 polymorphisms and the risk of childhood acute lymphoblastic leukemia. Leuk Res. 2009;33(6):759–63.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Postgraduate Program of Health and Sciences, Federal University of Piaui, 2280 Frei Serafim Avenue, Teresina, Piauí, 64049-550, Brazil

    Danylo Rafhael Costa-Silva, Maria da Conceição Barros-Oliveira, Rafael Soares Borges, Larysse Maira Campos-Verdes, João Paulo da Silva-Sampaio & Benedito Borges da Silva

  2. Postgraduate Program of the Northeast Network of Biotechnology (RENORBIO), Federal University of Piauí, Teresina, 64049-550, Brazil

    Danylo Rafhael Costa-Silva, Maria da Conceição Barros-Oliveira, Carla Solange Escorcio-Dourado, Luana Mota Martins & Benedito Borges da Silva

  3. Department of Statistics, University of São Paulo, São Paulo, 03178-200, Brazil

    Airlane Pereira Alencar

  4. Department of Gynecology, University of São Paulo, São Paulo, 03178-200, Brazil

    Edmund Chada Baracat

  5. Department of Molecular Biology, Natan Portella Hospital, Federal University of Piaui, Teresina, 64001-450, Brazil

    Vladimir Costa Silva

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  1. Danylo Rafhael Costa-Silva
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  2. Maria da Conceição Barros-Oliveira
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  11. Benedito Borges da Silva
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Correspondence to Benedito Borges da Silva.

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The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the Research Ethics Committee of the Federal University of Piauí (Teresina, Brazil; Approval No. 43447015.8.0000). All research is in compliance with the terms of the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Costa-Silva, D.R., da Conceição Barros-Oliveira, M., Borges, R.S. et al. Insulin-like growth factor 1 gene polymorphism in women with breast cancer. Med Oncol 34, 59 (2017). https://doi.org/10.1007/s12032-017-0915-4

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  • DOI: https://doi.org/10.1007/s12032-017-0915-4

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