Skip to main content

Advertisement

SpringerLink
Log in

Is there any effect of lower extremity deep vein thrombosis which proven by Doppler ultrasonography on cancer recurrence in patients with stage III colon cancer? A study of the Turkish Descriptive Oncological Researches Group

  • Original Paper
  • Published:
Medical Oncology Aims and scope Submit manuscript

Abstract

This study aimed to determine the predictive value of lower extremity deep vein thrombosis (LE-DVT) on first cancer recurrence in patients with stage III colon cancer. A total of 113 eligible patients with stage III colon cancer were divided into two groups according to whether they had LE-DVT. LE-DVT was detected in 29 (26 %) patients. Presence of recurrence with distant metastasis had a significant positive correlation with baseline platelet count, baseline mean platelet volume, and the presence of lower extremity deep vein thrombosis. It was concluded that the relation between disease progression and the presence of LE-DVT in stage III colon cancer is independent of other study variables (P = 0.031; OR = 4.27; 95 % CI 1.89–6.71). We hypothesized that the presence of LE-DVT in patients with stage III colon cancer may predict to early cancer recurrence with distant metastasis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. Falanga A, Zacharski L. Deep vein thrombosis in cancer: the scale of the problem and approaches to management. Ann Oncol. 2005;16:696–701.

    Article  PubMed  CAS  Google Scholar 

  2. Lee AYY, Levine MN. Venous thromboembolism and cancer: risks and outcomes. Circulation. 2003;107:17–21.

    Article  Google Scholar 

  3. Marras LC, Geerts WH, Perry JR. The risk of venous thromboembolism is increased throughout the course of malignant glioma: an evidence-based review. Cancer. 2000;89:640–6.

    Article  PubMed  CAS  Google Scholar 

  4. Lyman GH. Venous thromboembolism in the patient with cancer. Cancer. 2011;117:1334–49.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Samama MM. An epidemiologic study of risk factors for deep vein thrombosis in medical outpatients: the Sirius study. Arch Intern Med. 2000;160:3415–20.

    Article  PubMed  CAS  Google Scholar 

  6. Lee AY. Cancer and thromboembolic disease: pathogenic mechanisms. Cancer Treat Rev. 2002;28:137–40.

    Article  PubMed  CAS  Google Scholar 

  7. Tanriverdi O. Predictive value of baseline plasma D-dimers for chemotherapy-induced thrombocytopenia in patients with stage III colon cancer: a pilot study. Asian Pas J Cancer Prev. 2013;14:293–7.

    Article  Google Scholar 

  8. Antoniou D, Pavlakou G, Stathopoulos GP, Karydis I, Chondrou E, et al. Predictive value of D-dimer plasma levels in response and progressive disease in patients with lung cancer. Lung Cancer. 2006;53:205–10.

    Article  PubMed  Google Scholar 

  9. Sekhon SS, Roy V. Thrombocytopenia in adults: a practical approach to evaluation and management. South Med J. 2006;99:491–8.

    Article  PubMed  Google Scholar 

  10. Kirwan CC, McDowell G, McCollum CN, Kumar S, Byrne GJ. Early changes in the haemostatic and procoagulant systems after chemotherapy for breast cancer. Br J Cancer. 2008;99:1000–6.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  11. Gulcan M, Varol E, Etli M, Aksoy F, Kayan M. Mean platelet volume is increased in patients with deep vein thrombosis. Clin Appl Thromb Hemost. 2012;18:427–30.

    Article  PubMed  Google Scholar 

  12. Bilir C, Engin H, Bilir F. Increased mean platelet volume in deep vein thrombosis patients with cancer. J Hematol. 2013;2:64–8.

    Google Scholar 

  13. Goldenberg N, Kahn SR, Solymoss S. Markers of coagulation and angiogenesis in cancer-associated venous thromboembolism. J Clin Oncol. 2003;21:4194–9.

    Article  PubMed  CAS  Google Scholar 

  14. Sorensen HT, Mellemkj’r L, Olsen JH, Baron JA. Prognosis of cancers associated with venous thromboembolism. N Engl J Med. 2000;343:1846–50.

    Article  PubMed  CAS  Google Scholar 

  15. Seifter EJ, Young RC, Longo DL. Deep venous thrombosis during therapy for Hodgkin’s disease. Cancer Treat Rep. 1985;69:1011–3.

    PubMed  CAS  Google Scholar 

Download references

Acknowledgments

We would like to thank Roche Oncology Department of Medical Support for translating to English.

Conflict of interest

Authors declared no conflicts of interest.

Author information

Authors and Affiliations

  1. Department of Medical Oncology, Faculty of Medicine, Sitki Kocman University, Mugla, 48000, Turkey

    Ozgur Tanriverdi

  2. Department of Emergency Medicine, Sitki Kocman University Education and Research Hospital, Mugla, Turkey

    Birdal Yildirim

  3. Department of Radiodiagnostics, Sitki Kocman University Education and Research Hospital, Mugla, Turkey

    Suha Gul

  4. Department of Medical Oncology, Adnan Menderes University Faculty of Medicine, Aydın, Turkey

    Esin Cevik & Sabri Barutca

  5. Department of Medical Oncology, Tepecik Education and Research Hospital, Izmir, Turkey

    Tulay Akman

  6. Department of Medical Oncology, Kent Hospital, Izmir, Turkey

    Suna Cokmert

  7. Department of Medical Oncology, Faculty of Medicine, Bilim University, Istanbul, Turkey

    Kezban Nur Pilanci & Cetin Ordu

  8. Department of Medical Oncology, State Hospital, Balikesir, Turkey

    Nilufer Avci

Authors
  1. Ozgur Tanriverdi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Birdal Yildirim
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Suha Gul
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Esin Cevik
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Tulay Akman
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Suna Cokmert
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Kezban Nur Pilanci
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Nilufer Avci
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Cetin Ordu
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Sabri Barutca
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ozgur Tanriverdi.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Tanriverdi, O., Yildirim, B., Gul, S. et al. Is there any effect of lower extremity deep vein thrombosis which proven by Doppler ultrasonography on cancer recurrence in patients with stage III colon cancer? A study of the Turkish Descriptive Oncological Researches Group. Med Oncol 31, 215 (2014). https://doi.org/10.1007/s12032-014-0215-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1007/s12032-014-0215-1

Keywords

Search

Navigation