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The prognostic value of Cyclin B1 in pancreatic cancer

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Abstract

Pancreatic cancer (PC), a malignancy with very poor prognosis, presents many molecular alterations, including overexpression of Cyclin B1. However, the prognostic value of the protein in PC remains to be elucidated. In the present study, Cyclin B1 expression was detected immunohistochemically in specimens from 241 patients with PC and was correlated with clinicopathological features and patient survival. It was found that Cyclin B1 expression, located in nucleus and/or cytoplasm, was not statistically associated with clinicopathologic variables. However, overall survival of patients with high Cyclin B1 expression was significantly poorer than that of those with low Cyclin B1 expression (P = 0.010). Moreover, Cyclin B1 was identified as an independent prognostic factor by multivariate Cox regression test (P = 0.003). Finally, its independent implication for prognosis was proven in five subgroups of PC, i.e., males, patients aged ≤65 years, G1–2 and N0 tumors as well as those with perineural invasion (all P < 0.05). These data indicate that high expression of Cyclin B1 is a valuable molecular marker of unfavorable prognosis in PC.

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Acknowledgments

This work was supported by research special fund for public welfare industry of health (201202007) and National High Technology Research and Development Program (863 Program, 2014AA020609), China.

Conflict of interest

The authors ensure no potential conflicts of interest.

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Authors and Affiliations

  1. Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing, 100730, China

    Li Zhou, Jian Li, Yu-Pei Zhao, Jun-Chao Guo, Lei You, Wen-Ming Wu & Tai-Ping Zhang

  2. Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing, 100730, China

    Quan-Cai Cui & Wei-Xun Zhou

Authors
  1. Li Zhou
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  2. Jian Li
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  3. Yu-Pei Zhao
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Correspondence to Yu-Pei Zhao.

Additional information

Li Zhou and Jian Li have contributed equally to this study.

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Zhou, L., Li, J., Zhao, YP. et al. The prognostic value of Cyclin B1 in pancreatic cancer. Med Oncol 31, 107 (2014). https://doi.org/10.1007/s12032-014-0107-4

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  • DOI: https://doi.org/10.1007/s12032-014-0107-4

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