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Autophagy modification augmented the treatment effects initiated by arsenic trioxide in NB4 cells

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Abstract

Autophagy is a survival pathway required for cellular viability during starvation through catabolic self-digestion of damaged proteins and organelles; however, autophagy may result in cell death if it proceeds to completion. Although the exact mechanism of this process is not clear, it seems that proper regulation of autophagy can potentially contribute to the therapeutics of cancers. This study was designed to examine the role of autophagy in the death of human acute promyelocytic leukemia NB4 cells initiated by arsenic trioxide. Furthermore, the effects of autophagy inhibition and augmentation on cell viability were also compared. Our data suggested that both augmentation and suppression of autophagy could enhance the treatment effects while the latter was preferable. This study indicated that autophagy regulation augmented the treatment effects initiated by arsenic trioxide in NB4 cells, and that the selection of regulator should be precisely considered.

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Authors and Affiliations

  1. Lab of Electron Microscopy, Peking University First Hospital, No. 8 Xishiku Street, XiCheng District, 100034, Beijing, China

    YaLi Ren, YanLing Xie, LiJun Chai, ShuHe Wang & Ming Cheng

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  1. YaLi Ren
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  2. YanLing Xie
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  3. LiJun Chai
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  4. ShuHe Wang
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  5. Ming Cheng
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Correspondence to YaLi Ren.

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Ren, Y., Xie, Y., Chai, L. et al. Autophagy modification augmented the treatment effects initiated by arsenic trioxide in NB4 cells. Med Oncol 28, 231–236 (2011). https://doi.org/10.1007/s12032-010-9430-6

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  • DOI: https://doi.org/10.1007/s12032-010-9430-6

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