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High Levels of Il-19 in Patients with Chronic Inflammatory Demyelinating Polyneuropathy

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Abstract

Immune-mediated neuropathies include some specific types such as acute and chronic inflammatory demyelinating polyneuropathy (AIDP and CIDP). Previous studies have demonstrated abnormal cellular or humoral immune responses in these conditions. Although aberrant regulation of several cytokines have been reported in AIDP and CIDP, the significance of interleukin 19 (IL-19) in these conditions have not been elucidated yet. In the current study, we assessed serum levels of IL-19 in 12 CIDP patients (female/male ratio, 4/8), 9 AIDP patients (female/male ratio, 3/6), and 27 normal subjects (female/male ratio. 8/19) using commercial ELISA kits. Notably, we detected higher levels of this cytokine in CIDP patients (136.4 ± 8.57 ng/l) compared with both AIDP patients (93.89 ± 2.26 ng/l) and controls (83.78 ± 1.72 ng/l). However, the differences between AIDP patients and controls were not significant. The current study demonstrates the role of IL-19 in the pathogenesis of CIDP and potentiates this cytokine as a biomarker for this condition.

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Acknowledgments

The current study was supported by a grant number 9712218216 from Hamadan University of Medical Sciences.

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Authors and Affiliations

  1. Department of Immunology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

    Somayeh Sangsefidi

  2. Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Soudeh Ghafouri-Fard

  3. Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran

    Alireza Komaki & Mohammad Mahdi Eftekharian

  4. Department of Neurology, Hamadan University of Medical Sciences, Hamadan, Iran

    Mehrdokht Mazdeh

  5. Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Mohammad Taheri

Authors
  1. Somayeh Sangsefidi
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  2. Soudeh Ghafouri-Fard
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  3. Alireza Komaki
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  4. Mehrdokht Mazdeh
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  5. Mohammad Taheri
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  6. Mohammad Mahdi Eftekharian
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Corresponding authors

Correspondence to Mohammad Taheri or Mohammad Mahdi Eftekharian.

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The authors declare they have no conflict of interest.

The study protocol was approved by the ethical committee of Hamadan University of Medical Sciences (IR.UMSHA.REC.1397.948). All study participants signed the informed consent forms.

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Sangsefidi, S., Ghafouri-Fard, S., Komaki, A. et al. High Levels of Il-19 in Patients with Chronic Inflammatory Demyelinating Polyneuropathy. J Mol Neurosci 70, 1997–2000 (2020). https://doi.org/10.1007/s12031-020-01602-y

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  • DOI: https://doi.org/10.1007/s12031-020-01602-y

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