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Microstructural White Matter Abnormalities and Cognitive Dysfunction in Subcortical Ischemic Vascular Disease: an Atlas-Based Diffusion Tensor Analysis Study

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Abstract

Recent studies in subcortical ischemic vascular disease (SIVD) suggest the involvement of white matter (WM) abnormalities underlying the pathogenesis of cognitive function impairment. Here, we performed magnetic resonance diffusion tensor imaging (DTI) on detecting WM damage and to investigate the correlations between DTI measures and cognitive dysfunction in SIVD patients. Fifty right-handed SIVD patients were recruited and divided into vascular cognitive impairment on dementia (VCIND) group and normal cognition (NC) group. Twenty-two VCIND patients and 28 NC patients underwent DTI scanning and neuropsychological assessment. Atlas-based analysis (ABA) was performed on each subject for extracting FA and MD measures from supratentorial tracts. Among VCIND, as compared to NC patients, decreased FA and increased MD were observed in all projection fibers (bilateral anterior, posterior limb, and retrolenticular part of internal capsule, anterior, superior, and posterior corona radiata and posterior thalamic radiation), association fibers (bilateral sagittal stratum, external capsule, cingulum, fornix, and stria terminalis, superior longitudinal fasciculus, superior fronto-occipital fasciculus, and uncinate fasciculus), and commissural fibers (genu, body, splenium, and bilateral tapetum of corpus callosum). Furthermore, we also found that MoCA scores correlated with DTI values in all supratentorial WM tracts. The results suggested that SIVD patients demonstrated abnormal WM connectivity in all supratentorial regions. Moreover, the severity of damage in WM tracts correlated with cognitive dysfunction.

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References

  • Cui Z, Zhong S, Xu P, He Y, Gong G (2013) PANDA: a pipeline toolbox for analyzing brain diffusion images. Front Hum Neurosci 7:42. doi:10.3389/fnhum.2013.00042

    PubMed Central  PubMed  Google Scholar 

  • Della Nave R, Foresti S, Pratesi A, Ginestroni A, Inzitari M, Salvadori E, Giannelli M, Diciotti S, Inzitari D, Mascalchi M (2007) Whole-brain histogram and voxel-based analyses of diffusion tensor imaging in patients with leukoaraiosis: correlation with motor and cognitive impairment. Am J Neuroradiol 28(7):1313–1319. doi:10.3174/ajnr.A0555

    Article  CAS  PubMed  Google Scholar 

  • Erkinjuntti T, Inzitari D, Pantoni L, Wallin A, Scheltens P, Rockwood K, Roman GC, Chui H, Desmond DW (2000) Research criteria for subcortical vascular dementia in clinical trials. [Review]. J Neural Transm Suppl 59:23–30

    CAS  PubMed  Google Scholar 

  • Folstein MF, Folstein SE, McHugh PR (1975) “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12(3):189–198

    Article  CAS  PubMed  Google Scholar 

  • Frisoni GB, Galluzzi S, Bresciani L, Zanetti O, Geroldi C (2002) Mild cognitive impairment with subcortical vascular features: clinical characteristics and outcome. [Comparative Study]. J Neurol 249(10):1423–1432. doi:10.1007/s00415-002-0861-7

    Article  PubMed  Google Scholar 

  • Galluzzi S, Sheu CF, Zanetti O, Frisoni GB (2005) Distinctive clinical features of mild cognitive impairment with subcortical cerebrovascular disease. Dement Geriatr Cogn Disord 19(4):196–203. doi:10.1159/000083499

    Article  PubMed  Google Scholar 

  • Graham NL, Emery T, Hodges JR (2004) Distinctive cognitive profiles in Alzheimer's disease and subcortical vascular dementia. [Comparative Study Research Support, Non-U.S. Gov't]. J Neurol Neurosurg Psychiatry 75(1):61–71

    CAS  PubMed Central  PubMed  Google Scholar 

  • Hachinski V, Iadecola C, Petersen RC, Breteler MM, Nyenhuis DL, Black SE, Powers WJ, DeCarli C, Merino JG, Kalaria RN, Vinters HV, Holtzman DM, Rosenberg GA, Wallin A, Dichgans M, Marler JR, Leblanc GG (2006) National Institute of Neurological Disorders and Stroke-Canadian Stroke Network vascular cognitive impairment harmonization standards. [Practice Guideline]. Stroke 37(9):2220–2241. doi:10.1161/01.STR.0000237236.88823.47

    Article  PubMed  Google Scholar 

  • Jak AJ, Bondi MW, Delano-Wood L, Wierenga C, Corey-Bloom J, Salmon DP, Delis DC (2009) Quantification of five neuropsychological approaches to defining mild cognitive impairment. [Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.]. Am J Geriatr Psychiatr 17(5):368–375. doi:10.1097/JGP.0b013e31819431d5

    Article  Google Scholar 

  • Kim SH, Park JS, Ahn HJ, Seo SW, Lee JM, Kim ST, Han SH, Na DL (2011) Voxel-based analysis of diffusion tensor imaging in patients with subcortical vascular cognitive impairment: correlates with cognitive and motor deficits. [Research Support, Non-U.S. Gov't]. J Neuroimaging 21(4):317–324. doi:10.1111/j.1552-6569.2010.00527.x

    Article  PubMed  Google Scholar 

  • Meng JZ, Guo LW, Cheng H, Chen YJ, Fang L, Qi M, Jia ZY, Mohammed W, Hong XN (2012) Correlation between cognitive function and the association fibers in patients with Alzheimer's disease using diffusion tensor imaging. J Clin Neurosci 19(12):1659–1663. doi:10.1016/j.jocn.2011.12.031

    Article  PubMed  Google Scholar 

  • Moorhouse P, Rockwood K (2008) Vascular cognitive impairment: current concepts and clinical developments. [Research Support, Non-U.S. Gov't Review]. Lancet Neurol 7(3):246–255. doi:10.1016/S1474-4422(08)70040-1

    Article  PubMed  Google Scholar 

  • Mori S, Oishi K, Jiang H, Jiang L, Li X, Akhter K, Hua K, Faria AV, Mahmood A, Woods R, Toga AW, Pike GB, Neto PR, Evans A, Zhang J, Huang H, Miller MI, van Zijl P, Mazziotta J (2008) Stereotaxic white matter atlas based on diffusion tensor imaging in an ICBM template. [Research Support, N.I.H., Extramural]. Neuroimage 40(2):570–582. doi:10.1016/j.neuroimage.2007.12.035

    Article  PubMed Central  PubMed  Google Scholar 

  • Munoz DG, Hastak SM, Harper B, Lee D, Hachinski VC (1993) Pathologic correlates of increased signals of the centrum ovale on magnetic resonance imaging. [Research Support, Non-U.S. Gov't]. Arch Neurol 50(5):492–497

    Article  CAS  PubMed  Google Scholar 

  • Nasreddine ZS, Phillips NA, Bedirian V, Charbonneau S, Whitehead V, Collin I, Cummings JL, Chertkow H (2005) The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. [Evaluation Studies Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.]. J Am Geriatr Soc 53(4):695–699. doi:10.1111/j.1532-5415.2005.53221.x

    Article  PubMed  Google Scholar 

  • Oishi K, Faria A, Jiang H, Li X, Akhter K, Zhang J, Hsu JT, Miller MI, van Zijl PC, Albert M, Lyketsos CG, Woods R, Toga AW, Pike GB, Rosa-Neto P, Evans A, Mazziotta J, Mori S (2009) Atlas-based whole brain white matter analysis using large deformation diffeomorphic metric mapping: application to normal elderly and Alzheimer's disease participants. Neuroimage 46(2):486–499

    Article  PubMed Central  PubMed  Google Scholar 

  • O'Sullivan M, Summers PE, Jones DK, Jarosz JM, Williams SC, Markus HS (2001) Normal-appearing white matter in ischemic leukoaraiosis: a diffusion tensor MRI study. [Research Support, Non-U.S. Gov't]. Neurology 57(12):2307–2310

    Article  PubMed  Google Scholar 

  • O'Sullivan M, Morris RG, Huckstep B, Jones DK, Williams SC, Markus HS (2004) Diffusion tensor MRI correlates with executive dysfunction in patients with ischaemic leukoaraiosis. [Clinical Trial Research Support, Non-U.S. Gov't]. J Neurol Neurosurg Psychiatry 75(3):441–447

    Article  PubMed Central  PubMed  Google Scholar 

  • Otsuka Y, Yamauchi H, Sawamoto N, Iseki K, Tomimoto H, Fukuyama H (2012) Diffuse tract damage in the hemispheric deep white matter may correlate with global cognitive impairment and callosal atrophy in patients with extensive leukoaraiosis. AJNR Am J Neuroradiol 33(4):726–732. doi:10.3174/ajnr.A2853

    Article  CAS  PubMed  Google Scholar 

  • Petersen RC (2004) Mild cognitive impairment as a diagnostic entity. J Intern Med 256(3):183–194. doi:10.1111/j.1365-2796.2004.01388.x

    Article  CAS  PubMed  Google Scholar 

  • Ravaglia G, Forti P, Maioli F, Martelli M, Servadei L, Brunetti N, Pantieri G, Mariani E (2006) Conversion of mild cognitive impairment to dementia: predictive role of mild cognitive impairment subtypes and vascular risk factors. [Research Support, Non-U.S. Gov't]. Dement Geriatr Cogn Disord 21(1):51–58. doi:10.1159/000089515

    Article  PubMed  Google Scholar 

  • Reijmer YD, Brundel M, de Bresser J, Kappelle LJ, Leemans A, Biessels GJ (2013) Microstructural white matter abnormalities and cognitive functioning in type 2 diabetes: a diffusion tensor imaging study. [Research Support, Non-U.S. Gov't]. Diabetes Care 36(1):137–144. doi:10.2337/dc12-0493

    Article  PubMed Central  PubMed  Google Scholar 

  • Roman GC, Erkinjuntti T, Wallin A, Pantoni L, Chui HC (2002) Subcortical ischaemic vascular dementia. [Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review]. Lancet Neurol 1(7):426–436

    Article  PubMed  Google Scholar 

  • Seo SW, Ahn J, Yoon U, Im K, Lee JM, Tae Kim S, Ahn HJ, Chin J, Jeong Y, Na DL (2010) Cortical thinning in vascular mild cognitive impairment and vascular dementia of subcortical type. [Research Support, Non-U.S. Gov't]. J Neuroimaging 20(1):37–45. doi:10.1111/j.1552-6569.2008.00293.x

    Article  PubMed  Google Scholar 

  • Shim YS, Yoon B, Shon YM, Ahn KJ, Yang DW (2008) Difference of the hippocampal and white matter microalterations in MCI patients according to the severity of subcortical vascular changes: neuropsychological correlates of diffusion tensor imaging. [Research Support, Non-U.S. Gov't]. Clin Neurol Neurosurg 110(6):552–561. doi:10.1016/j.clineuro.2008.02.021

    Article  PubMed  Google Scholar 

  • Xu Q, Zhou Y, Li YS, Cao WW, Lin Y, Pan YM, Chen SD (2010) Diffusion tensor imaging changes correlate with cognition better than conventional MRI findings in patients with subcortical ischemic vascular disease. [Comparative Study Research Support, Non-U.S. Gov't]. Dement Geriatr Cogn Disord 30(4):317–326. doi:10.1159/000320491

    Article  PubMed  Google Scholar 

  • Zarei M, Damoiseaux JS, Morgese C, Beckmann CF, Smith SM, Matthews PM, Scheltens P, Rombouts SA, Barkhof F (2009) Regional white matter integrity differentiates between vascular dementia and Alzheimer disease. Stroke 40(3):773–779. doi:10.1161/strokeaha.108.530832

    Article  PubMed  Google Scholar 

  • Zhang B, Wen CY, Wang L, Zhang X (2011) Functional MRI and cognition assessment in subcortical ischemic vascular disease]. [Controlled Clinical Trial. Zhonghua Nei Ke Za Zhi 50(5):411–415

    CAS  PubMed  Google Scholar 

  • Zheng Z, Shemmassian S, Wijekoon C, Kim W, Bookheimer SY, Pouratian N (2014) DTI correlates of distinct cognitive impairments in Parkinson's disease. Hum Brain Mapp 35(4):1325–1333. doi:10.1002/hbm.22256

    Article  PubMed Central  PubMed  Google Scholar 

  • Zhou A, Jia J (2009) A screen for cognitive assessments for patients with vascular cognitive impairment no dementia. [Research Support, Non-U.S. Gov't]. Int J Geriatr Psychiatr 24(12):1352–1357. doi:10.1002/gps.2265

    Article  Google Scholar 

  • Zhou Y, Lin FC, Zhu J, Zhuang ZG, Li YS, Tao J, Qian LJ, Xu JR, Lei H (2008) Whole brain diffusion tensor imaging histogram analysis in vascular cognitive impairment. [Research Support, Non-U.S. Gov't]. J Neurol Sci 268(1–2):60–64. doi:10.1016/j.jns.2007.11.005

    Article  PubMed  Google Scholar 

  • Zhou Y, Qun X, Qin LD, Qian LJ, Cao WW, Xu JR (2011) A primary study of diffusion tensor imaging-based histogram analysis in vascular cognitive impairment with no dementia. [Research Support, Non-U.S. Gov't]. Clin Neurol Neurosurg 113(2):92–97. doi:10.1016/j.clineuro.2010.09.007

    Article  PubMed  Google Scholar 

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Acknowledgments

This research was supported by the Fujian Science and Technology Project (combined application research of functional magnetic resonance for non-dementia vascular cognitive impairment, Social Development of Key Project, NO.2009Y0020).

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The authors have nothing to disclose.

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Authors and Affiliations

  1. Department of Radiology, Fujian Medical University Union Hospital, Fuzhou, Fujian, China

    Lin Lin, Yunjing Xue, Qing Duan, Bin Sun, Hailong Lin & Xiaodan Chen

  2. Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, Fujian, China

    Ling Luo & Xiaofan Wei

  3. GE Healthcare China, Beijing, China

    Zhongping Zhang

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  1. Lin Lin
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  2. Yunjing Xue
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  4. Bin Sun
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  6. Xiaodan Chen
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  7. Ling Luo
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  8. Xiaofan Wei
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  9. Zhongping Zhang
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Correspondence to Yunjing Xue.

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Lin, L., Xue, Y., Duan, Q. et al. Microstructural White Matter Abnormalities and Cognitive Dysfunction in Subcortical Ischemic Vascular Disease: an Atlas-Based Diffusion Tensor Analysis Study. J Mol Neurosci 56, 363–370 (2015). https://doi.org/10.1007/s12031-015-0550-5

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  • DOI: https://doi.org/10.1007/s12031-015-0550-5

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