Abstract
Introduction
One anastomosis gastric bypass (OAGB) is mainly criticized for the supposed carcinogenic effect of bile reflux on the gastric pouch mucosa.
Case presentation
A 56-year-old male patient presented 12 years after OAGB with a 10-month history of gradual dysphagia and vomiting. He was diagnosed with a tumor of the gastro-jejunal anastomosis, and underwent total gastrectomy with D2 lymphadenectomy. Specimen examination showed a diffuse isolated cell-type adenocarcinoma. To our knowledge, we report the first case in literature of adenocarcinoma of the gastro-jejunal anastomosis post-OAGB, and the second reported case if we include the Mason loop gastric bypass, which was the earlier version of OAGB with a different conceptual and physiological aspect.
Conclusion
The carcinogenic effect of bile reflux in OAGB will remain hypothetical until a detailed controlled study may prove the causality between bile reflux and gastric pouch malignancies in patients with a history of OAGB.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Data Availability
The data that support the findings of this study are available from the corresponding author upon reasonable request.
References
Rutledge R. The mini-gastric bypass: experience with the first 1,274 cases. Obes Surg. 2001;11(3):276–80. https://doi.org/10.1381/096089201321336584.
García-Caballero M, Carbajo M. One anastomosis gastric bypass: a simple, safe and efficient surgical procedure for treating morbid obesity. Nutr Hosp. 2004;19(6):372–5.
Rutledge R, Walsh TR. Continued excellent results with the mini-gastric bypass: six-year study in 2,410 patients. Obes Surg. 2005;15(9):1304–8. https://doi.org/10.1381/096089205774512663.
Chemaly R, Diab S, Khazen G, Al-Hajj G. Gastroesophageal cancer after gastric bypass surgeries: a systematic review and meta-analysis. Obes Surg. 2022;32(4):1300–11. https://doi.org/10.1007/s11695-022-05921-4.
Parmar C, Pouwels S. Oesophageal and gastric cancer after bariatric surgery: an up-to-date systematic scoping review of literature of 324 cases. Obes Surg. 2022;32(12):3854–62. https://doi.org/10.1007/s11695-022-06304-5.
Babor R, Booth M. Adenocarcinoma of the gastric pouch 26 years after loop gastric bypass. Obes Surg. 2006;16(7):935–8. https://doi.org/10.1381/096089206777822223.
Praud D, Rota M, Pelucchi C, et al. Cigarette smoking and gastric cancer in the stomach cancer pooling (StoP) project. Eur J Cancer Prev Off J Eur Cancer Prev Organ ECP. 2018;27(2):124–33. https://doi.org/10.1097/CEJ.0000000000000290.
Author information
Authors and Affiliations
Contributions
All authors have contributed significantly to the content of the manuscript. All authors are in agreement with the content of the manuscript.
Corresponding author
Ethics declarations
Consent to Participate
The consent was clearly obtained from the patient.
Conflict of Interest
The authors declare no competing interests.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
The content has not been published or submitted for publication elsewhere.
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Mouawad, C., Dahboul, H., Kazan, D. et al. Adenocarcinoma of the Gastro-jejunal Anastomosis After One Anastomosis Gastric Bypass. J Gastrointest Canc 55, 190–192 (2024). https://doi.org/10.1007/s12029-023-00968-7
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12029-023-00968-7