Abstract
Background
Increased 30-day mortality rates have been reported in patients undergoing elective surgery later compared with earlier in the week. However, these reports have been conflicting for esophageal surgery. We conducted a study to assess the differences in outcomes of patients undergoing surgery for esophageal cancer earlier in the week (Tuesday) versus later (Friday).
Methods
This retrospective analysis of a prospectively maintained database included patients with esophageal cancer who underwent esophageal resection in a tertiary cancer center between 1 January 2005 and 31 December 2017. We compared patients operated on Tuesdays versus Fridays. The primary outcome was a composite of major morbidity (defined as Clavien-Dindo grade 3 or more) and/or mortality. Secondary outcomes included duration of post-operative ventilation, and length of ICU and hospital stay.
Results
Among 1300 patients included, 733 were operated on a Tuesday and 567 on a Friday. Patient and surgery characteristics were similar in the two groups. The primary outcome (composite of major morbidity and mortality) was 23.6% in the Tuesday group versus 26.3% in the Friday group. Mortality was similar in the two groups (6.0%). Multivariable logistic regression analysis showed that the day of surgery was not a predictor of major morbidity or mortality.
Conclusions
In patients undergoing esophagectomy at tertiary care high volume cancer center, there was no difference in major morbidity and mortality whether the surgery was performed early in the week (Tuesday) or closer to the weekend (Friday).
Similar content being viewed by others
Availability of Data and Material
Yes, on request.
Change history
08 September 2022
A Correction to this paper has been published: https://doi.org/10.1007/s12029-022-00860-w
References
Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394–424.
Wong MCS, Hamilton W, Whiteman DC, Jiang JY, Qiao Y, Fung FDH, Wang HHX, Chiu PWY, Ng EKW, Wu JCY, Yu J, Chan FKL, Sung JJY. Global Incidence and mortality of oesophageal cancer and their correlation with socioeconomic indicators temporal patterns and trends in 41 countries. Sci Rep. 2018;8(1):4522.
Omloo JM, Lagarde SM, Hulscher JB, Reitsma JB, Fockens P, van Dekken H, Ten Kate FJ, Obertop H, Tilanus HW, van Lanschot JJ. Extended transthoracic resection compared with limited transhiatal resection for adenocarcinoma of the mid/distal esophagus: five-year survival of a randomized clinical trial. Ann Surg. 2007;246(6):992–1000 discussion 1000-1.
van Hagen P, Hulshof MC, van Lanschot JJ, Steyerberg EW, van Berge Henegouwen MI, Wijnhoven BP, Richel DJ, Nieuwenhuijzen GA, Hospers GA, Bonenkamp JJ, Cuesta MA, Blaisse RJ, Busch OR, ten Kate FJ, Creemers GJ, Punt CJ, Plukker JT, Verheul HM, Spillenaar Bilgen EJ, van Dekken H, van der Sangen MJ, Rozema T, Biermann K, Beukema JC, Piet AH, van Rij CM, Reinders JG, Tilanus HW, van der Gaast A, CROSS Group. Preoperative chemoradiotherapy for esophageal or junctional cancer. N Engl J Med. 2012;366(22):2074–84.
Al-Batran SE, Homann N, Pauligk C, Goetze TO, Meiler J, Kasper S, Kopp HG, Mayer F, Haag GM, Luley K, Lindig U, Schmiegel W, Pohl M, Stoehlmacher J, Folprecht G, Probst S, Prasnikar N, Fischbach W, Mahlberg R, Trojan J, Koenigsmann M, Martens UM, Thuss-Patience P, Egger M, Block A, Heinemann V, Illerhaus G, Moehler M, Schenk M, Kullmann F, Behringer DM, Heike M, Pink D, Teschendorf C, Löhr C, Bernhard H, Schuch G, Rethwisch V, von Weikersthal LF, Hartmann JT, Kneba M, Daum S, Schulmann K, Weniger J, Belle S, Gaiser T, Oduncu FS, Güntner M, Hozaeel W, Reichart A, Jäger E, Kraus T, Mönig S, Bechstein WO, Schuler M, Schmalenberg H, Hofheinz RD, FLOT4-AIO Investigators. Perioperative chemotherapy with fluorouracil plus leucovorin, oxaliplatin, and docetaxel versus fluorouracil or capecitabine plus cisplatin and epirubicin for locally advanced, resectable gastric or gastrooesophageal junction adenocarcinoma (FLOT4): a randomised, phase 2/3 trial. Lancet. 2019;393(10184):1948–57.
Gisbertz SS, Hagens ERC, Ruurda JP, Schneider PM, Tan LJ, Domrachev SA, Hoeppner J, van Berge Henegouwen MI. The evolution of surgical approach for esophageal cancer. Ann N Y Acad Sci. 2018;1434(1):149–55.
Markar SR, Lagergren J. Surgical and surgeon-related factors related to long-term survival in esophageal cancer: a review. Ann Surg Oncol. 2020;27(3):718–23.
Ashok A, Niyogi D, Ranganathan P, Tandon S, Bhaskar M, Karimundackal G, Jiwnani S, Shetmahajan M, Pramesh CS. The enhanced recovery after surgery (ERAS) protocol to promote recovery following esophageal cancer resection. Surg Today. 2020;50(4):323–34.
Pauls LA, Johnson-Paben R, McGready J, Murphy JD, Pronovost PJ, Wu CL. The weekend effect in hospitalized patients: a meta-analysis. J Hosp Med. 2017;12(9):760–6.
Aylin P, Yunus A, Bottle A, Majeed A, Bell D. Weekend mortality for emergency admissions. A large, multicentre study. Qual Saf Health Care. 2010;19(3):213–7.
Dorn SD, Shah ND, Berg BP, Naessens JM. Effect of weekend hospital admission on gastrointestinal hemorrhage outcomes. Dig Dis Sci. 2010;55(6):1658–66.
Kim YY, Gauvreau K, Bacha EA, Landzberg MJ, Benavidez OJ. Resource use among adult congenital heart surgery admissions in pediatric hospitals: risk factors for high resource utilization and association with inpatient death. Circ Cardiovasc Qual Outcomes. 2011;4(6):634–9.
Dubois L, Vogt K, Vinden C, Winick-Ng J, McClure JA, Roshanov PS, Bell CM, Garg AX. Surgical Investigators Group at ICES Western. Association between day of the week of elective surgery andpostoperative mortality. CMAJ. 2017;189(8):E303–9.
Ruiz M, Bottle A, Aylin PP. Exploring the impact of consultants’ experience on hospital mortality by day of the week: a retrospective analysis of hospital episode statistics. BMJ Qual Saf. 2016;25(5):337–44.
Aylin P, Alexandrescu R, Jen MH, Mayer EK, Bottle A. Day of week of procedure and 30-day mortality for elective surgery: retrospective analysis of hospital episode statistics. BMJ. 2013;28(346): f2424.
Ruiz M, Bottle A, Aylin PP. The Global Comparators project: international comparison of 30-day in-hospital mortality by day of the week. BMJ Qual Saf. 2015;24(492):504.
Lagergren J, Mattsson F, Lagergren P. Weekday of oesophageal cancer surgery in relation to early postoperative outcomes in a nationwide Swedish cohort study. BMJ Open. 2016;6(5):e011097.
Lagergren J, Mattsson F, Lagergren P. Weekday of esophageal cancer surgery and its relation to prognosis. Ann Surg. 2016;263(6):1133-7.19.
Visser E, van Rossum PSN, Verhoeven RHA, Ruurda JP, van Hillegersberg R. Impact of weekday of esophagectomy on short-term and long-term oncological outcomes: a nationwide population-based cohort study in the Netherlands. Ann Surg. 2017;266(1):76–81.
Yoshida N, Baba Y, Watanabe M, Ida S, Ishimoto T, Karashima R, Iwagami S, Imamura Y, Sakamoto Y, Miyamoto Y, Baba H. Original scoring system for predicting postoperative morbidity after esophagectomy for esophageal cancer. Surg Today. 2015;45:346–54.
Jiang R, Liu Y, Ward KC, Force SD, Pickens A, Sancheti MS, Javidfar J, Fernandez FG, Khullar OV. Excess cost and predictive factors of esophagectomy complications in the SEER-Medicare Database. Ann Thorac Surg. 2018;106:1484–91.
Low DE, Kuppusamy MK, Alderson D, Cecconello I, Chang AC, Darling G, Davies A, D’Journo XB, Gisbertz SS, Griffin SM, Hardwick R, Hoelscher A, Hofstetter W, Jobe B, Kitagawa Y, Law S, Mariette C, Maynard N, Morse CR, Nafteux P, Pera M, Pramesh CS, Puig S, Reynolds JV, Schroeder W, Smithers M, Wijnhoven BPL. Benchmarking complications associated with esophagectomy. Ann Surg. 2019;269:291–8.
Hodari A, Hammoud ZT, Borgi JF, Tsiouris A, Rubinfeld IS. Assessment of morbidity and mortality after esophagectomy using a modified frailty index. Ann Thorac Surg. 2013;96(4):1240–5.
Smith SA, Yamamoto JM, Roberts DJ, Tang KL, Ronksley PE, Dixon E, Buie WD, James MT. Weekend surgical care and postoperative mortality: a systematic review and meta-analysis of cohort studies. Med Care. 2018;56(2):121–9.
Zapf MA, Kothari AN, Markossian T, Gupta GN, Blackwell RH, Wai PY, Weber CE, Driver J, Kuo PC. The “weekend effect” in urgent general operative procedures. Surgery. 2015;158(2):508–14.
Goldstein SD, Papandria DJ, Aboagye J, Salazar JH, Van Arendonk K, Al-Omar K, Ortega G, Sacco Casamassima MG, Abdullah F. The, “weekend effect” in pediatricsurgery – increased mortality for children undergoing urgent surgery during the weekend. J Pediatr Surg. 2014;49(7):1087–91.
Ricciardi R, Nelson J, Francone TD, Roberts PL, Read TE, Hall JF, Schoetz DJ, Marcello PW. Do patient safety indicators explain increased weekend mortality? J Surg Res. 2016;200(1):164–70.
Smith SA, Yamamoto JM, Roberts DJ, et al. Weekend surgical care and postoperative mortality: a systematic review and meta-analysis of cohort studies. Med Care. 2018;56(2):121–9.
Worni M, Østbye T, Gandhi M, Rajgor D, Shah J, Shah A, Pietrobon R, Jacobs DO, Guller U. Laparoscopic appendectomy outcomes on the weekend and during the week are no different: a national study of 151,774 patients. World J Surg. 2012;36(7):1527–33.
Flynn P. Should the NHS work at weekends as it does in the week? No. BMJ. 2013;20(346):f622.
Glance LG, Osler T, Li Y, Lustik SJ, Eaton MP, Dutton RP, Dick AW. Outcomes are worse in US patients undergoing surgery on weekends compared with weekdays. Med Care. 2016;54(6):608.
Njølstad TS, Werner HM, Marcickiewicz J, Tingulstad S, Staff AC, Oddenes K, Bjørge L, Engh ME, Woie K, Tjugum J, Lode MS, Amant F, Salvesen HB, Trovik J. Late-week surgical treatment of endometrial cancer is associated with worse long-term outcome: results from a prospective, multicenter study. PLoS ONE. 2017;12(8):e0182223.
Huijts DD, Guicherit OR, Dekker JWT, van Groningen JT, van Bodegom-Vos L, Bastiaannet E, Govaert JA, Wouters MW, Marang-van de Mheen PJ. Do outcomes in elective colon and rectal cancer surgery differ by weekday? An Observational Study Using Data From the Dutch ColoRectal Audit. J Natl Compr Canc Netw. 2019;17(7):821–8.
Frostberg E, Christensen RD, Rahr HB. The day of week of elective colorectal cancer surgery has no impact on mortality and morbidity. Dan Med J. 2019;66(7):A5550.
Visser E, Brenkman HJF, Verhoeven RHA, Ruurda JP, van Hillegersberg R. Weekday of gastrectomy for cancer in relation to mortality and oncological outcomes - a Dutch population-based cohort study. Eur J Surg Oncol. 2017;43(10):1862–8.
Austin PC, Mamdani MM, Juurlink DN, Hux JE. Testing multiple statistical hypotheses resulted in spurious associations: a study of astrological signs andhealth. J Clin Epidemiol. 2006;59(9):964–9.
Li L, Rothwell PM, Oxford Vascular Study. Biases in detection of apparent “weekend effect” on outcome with administrative coding data: population based study of stroke. BMJ. 2016;353:i2648.
Chen Y, Armoiry X, Higenbottam C, Cowley N, Basra R, Watson SI, Tarrant C, Boyal A, Sutton E, Wu CW, Aldridge CP, Gosling A, Lilford R, Bion J. Magnitude and modifiers of the weekend effect in hospital admissions: a systematic review and meta-analysis. BMJ Open. 2019;9:e025764.
Author information
Authors and Affiliations
Contributions
SJ and PR contributed to the study design and IEC submission. SJ, PR, and CSP contributed to the data collection. PR did the statistical analysis. SJ and PR prepared the initial manuscript. CSP provided administrative support and refined the manuscript.
Corresponding author
Ethics declarations
Ethics Approval
Approved by institutional IRB.
Competing Interests
The authors declare no competing interests.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
In the published article “The “Weekday Effect”—Does It Impact Esophageal Cancer Surgery Outcomes?” there is a correction that has been missed out in one of the tables. The number of transthoracic esophagectomy done on Friday is missing in table 1. In the type of surgery section of the table, The first row is transthoracic esophagectomy. The number of procedures performed on Friday is 463 (81%).
Rights and permissions
Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Jiwnani, S., Pramesh, C.S. & Ranganathan, P. The “Weekday Effect”—Does It Impact Esophageal Cancer Surgery Outcomes?. J Gastrointest Canc 54, 970–977 (2023). https://doi.org/10.1007/s12029-022-00855-7
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12029-022-00855-7