Abstract
The non-specific clinical symptoms of anorectal brownish-black mass do not help to differentiate colorectal cancer, hemorrhoids, rectal ulcers which result in a delayed diagnosis or lead to inadequate management of lethal anorectal melanoma. Primary malignant melanoma of the anorectal region is an uncommon tumor, constituting approximately 1% of anal canal tumors which may be misdiagnosed clinically as hemorrhoids. Because of aggressive behavior and poor prognosis, efficient and prompt diagnosis is required in these cases. We report 2 cases of this rare tumor.
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References
Dodds TJ, Wilmott JS, Jackett LA, Lo SN, Long GV, Thompson JF, Scolyer RA. Primary anorectal melanoma: clinical, immunohistology and DNA analysis of 43 cases. Pathology. 2019;51:39–45.
Scolyer RA, Prieto VG. Mucosal melanoma of digestive system. In: Lokuhetty D, White VA, Watanabe R, Cree IA editors. WHO classification of Tumours Editorial Board. Digestive System Tumours. 5th edition. Lyon: IARC; 2019. p502–503.
Kobakova I, Stoyanov G, Popov H, Spasova-Nyagulova S, Stefanova N, Stoev L, et al. Anorectal melanoma - a histopathological case report and a review of the literature. Folia Med (Plovdiv). 2018;60:641–6.
Nunez Herrero L, Chaucer B, Zafar W, Davalos F, Salman S, Naing S. Primary malignant melanoma of the rectum: a case report of an extremely rare gastrointestinal cancer. J Gastrointest Cancer. 2016;47:494–6.
Charifa A, Zhang X. Morphologic and immunohistochemical characteristics of anorectal melanoma. Int J Surg Pathol. 2018;26:725–9.
Coyne JD, O’Byrne P. Malignant melanoma of the rectum presenting as cloacogenic polyp: a case report. Ann R Coll Surg Engl. 2020;102:e67–9.
Dai JJ, Qu CS, Wang W, Wang YB, Mao XW, Li QS, Chen JF. Primary anorectal malignant melanoma: a case report. Int J Clin Exp Pathol. 2020;13:272–6.
Atak I. Anorectal malignant melanoma: retrospective analysis of six patients and review of the literature. Prague Med Rep. 2018;119:97–106.
Ni S, Huang D, Chen X, Huang J, Kong Y, Xu Y, Du X, Sheng W. c-kit gene mutation and CD117 expression in human anorectal melanomas. Hum Pathol. 2012;43:801–7.
Willis BC, Johnson G, Wang J, Cohen C. SOX10: a useful marker for identifying metastatic melanoma in sentinel lymph nodes. Appl Immunohistochem Mol Morphol. 2015;23:109–12.
Compton LA, Murphy GF, Lian CG. Diagnostic immunohistochemistry in cutaneous neoplasia: an update. Dermatopathology (Basel). 2015;2:15–42.
Yap LB, Neary P. A comparison of wide local excision with abdominoperineal resection in anorectal melanoma. Melanoma Res. 2004;14:147–50.
Ishizone S, Koide N, Karasawa F, Akita N, Muranaka F, Uhara H, Miyagawa S. Surgical treatment for anorectal malignant melanoma: report of five cases and review of 79 Japanese cases. Int J Colorectal Dis. 2008;23:1257–62.
Kelly P, Zagars GK, Cormier JN, Ross MI, Guadagnolo BA. Sphincter-sparing local excision and hypofractionated radiation therapy for anorectal melanoma: a 20-year experience. Cancer. 2011;117:4747–55.
Postow MA, Luke JJ, Bluth MJ, Ramaiya N, Panageas KS, Lawrence DP, et al. Ipilimumab for patients with advanced mucosal melanoma. Oncologist. 2013;18(6):726–32.
D’Angelo SP, Larkin J, Sosman JA, Lebbé C, Brady B, Neyns B, et al. Efficacy and safety of nivolumab alone or in combination with ipilimumab in patients with mucosal melanoma: a pooled analysis. J Clin Oncol. 2017;35:226–35.
Welton ML, Steele SR, Goodma KA, Gunderson LL, Asare EA, Brierley JD, Compton CC, de Nardi P, Goldberg RM, Gress D, Washington MK, Jessup JM. Anus. In: Amin MB editor in-chief. AJCC Cancer Staging Manual. 8th Edition. Chicago: American College of Surgeons; 2017. p-275.
Falch C, Stojadinovic A, Hann-von-Weyhern C, Protic M, Nissan A, Faries MB, Daumer M, Bilchik AJ, Itzhak A, Brücher BL. Anorectal malignant melanoma: extensive 45-year review and proposal for a novel staging classification. J Am Coll Surg. 2013;217:324–35.
Sarac E, Amaral T, Keim U, Leiter U, Forschner A, Eigentler TK, Garbe C. Prognostic factors in 161 patients with mucosal melanoma: a study of German Central Malignant Melanoma Registry. J Eur Acad Dermatol Venereol. 2020. https://doi.org/10.1111/jdv.16306. Epub ahead of print.
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Drafting of the manuscript: Jitendra Singh Nigam, Avinash Singh, Nishit, Prerna Tewari. Literature search: Tarun Kumar, Jitendra Singh Nigam, Avinash Singh, Nishit, Prerna Tewari. Case acquisition: Jitendra Singh Nigam, Nishit, Avinash Singh, Tarun Kumar, Jagjit Kumar Pandey. Case analysis and interpretation: Avinash Singh, Prerna Tewari, Jitendra Singh Nigam, Nishit. Manuscript preparation: Jitendra Singh Nigam, Avinash Singh, Nishit, Prerna Tewari. Manuscript editing: Tarun Kumar, Jitendra Singh Nigam, Jagjit Kumar Pandey. Manuscript review and approval: Tarun Kumar, Jitendra Singh Nigam, Jagjit Kumar Pandey, Avinash Singh, Nishit, Prerna Tewari.
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Nigam, J.S., Nishit, Kumar, T. et al. Anorectal Melanoma—Brownish Black Mass Not Always a Hemorrhoid. J Gastrointest Canc 53, 825–829 (2022). https://doi.org/10.1007/s12029-021-00678-y
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DOI: https://doi.org/10.1007/s12029-021-00678-y