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Incidence and Preoperative Predictor Factors of Gallbladder Cancer Before Laparoscopic Cholecystectomy: a Systematic Review

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Abstract

Introduction

Many cases of gallbladder cancer (GBC) were made incidentally after cholecystectomy for presumed benign disease. The aim of this review is to assess the preoperative predictor factors of gallbladder cancer.

Methods

This systematic review was conducted according to PRISMA guidelines when it was applicable. We conducted bibliographic researches on October 2nd, 2019, in the following sources: The National Library of Medicine through PubMed, Cochrane database, and Google scholar. We have assessed the univariate and multivariate analysis outcomes.

Results

We included ten studies. Incidence of incidental GBC was 0.36%. Seven studies reported age as a significant predictive factor of iGBC. Comorbidities were the second significant predictor. One study found that iGBC group was more likely to have elevated TB, DB, PAL, and ALT. Another study reported a significantly higher rate of TB, PAL, and AST. One study concluded that elevated CA19-9 combined with CEA or CA-125 was significantly more frequent in the group with iGBC. Polyps, porcelain GB, GB wall thickness, and CBD dilation were reported to be associated with iGBC. iGBC group were more likely to have solitary and larger GS and gallbladder wall thickening, essentially focal.

Conclusion

Incidence of iGBC was 0.365% varying between 0.19 and 1.6% of laparoscopic cholecystectomy and about 50% of GBC cases. This highlights the deficiency of preoperative diagnostic features. Despite the efforts made, the rate of this condition is still high, underlining the need of new radiological technologies.

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Authors and Affiliations

  1. Department of Visceral Surgery, Fattouma Bourguiba Hospital, Monastir, Tunisia

    Tarek Kellil, Mohamed Ali Chaouch, Emna Aloui, Mohamed Amine Tormane, Sahbi Khaled Taieb, Faouzi Noomen & Khadija Zouari

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  1. Tarek Kellil
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  2. Mohamed Ali Chaouch
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  3. Emna Aloui
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  4. Mohamed Amine Tormane
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  5. Sahbi Khaled Taieb
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  6. Faouzi Noomen
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  7. Khadija Zouari
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All authors read and approved the final manuscript.

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Correspondence to Mohamed Ali Chaouch.

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Kellil, T., Chaouch, M.A., Aloui, E. et al. Incidence and Preoperative Predictor Factors of Gallbladder Cancer Before Laparoscopic Cholecystectomy: a Systematic Review. J Gastrointest Canc 52, 68–72 (2021). https://doi.org/10.1007/s12029-020-00524-7

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  • DOI: https://doi.org/10.1007/s12029-020-00524-7

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