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Cerebral Fat Embolism: Recognition, Complications, and Prognosis

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Abstract

Fat embolism syndrome (FES) is a rare syndrome caused by embolization of fat particles into multiple organs including the brain. It typically manifests with petechial rash, deteriorating mental status, and progressive respiratory insufficiency, usually occurring within 24–48 h of trauma with long-bone fractures or an orthopedic surgery. The diagnosis of FES is based on clinical and imaging findings, but requires exclusion of alternative diagnoses. Although there is no specific treatment for FES, prompt recognition is important because it can avoid unnecessary interventions and clarify prognosis. Patients with severe FES can become critically ill, but even comatose patients with respiratory failure may recover favorably. Prophylactic measures, such as early stabilization of fractures and certain intraoperative techniques, may help decrease the incidence and severity of FES.

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Author information

Authors and Affiliations

  1. Neurointensive Care Unit, Sanatorio Pasteur, Chacabuco 675, 4700, Catamarca, Argentina

    Daniel Agustín Godoy

  2. Intensive Care Unit, Hospital San Juan Bautista, Catamarca, Argentina

    Daniel Agustín Godoy

  3. Neurological Service, San Camillo de’ Lellis General Hospital, Rieti, Italy

    Mario Di Napoli

  4. Neurological Section, SMDN—Center for Cardiovascular Medicine and Cerebrovascular Disease Prevention, Sulmona, L’Aquila, Italy

    Mario Di Napoli

  5. Neuroscience Critical Care Unit, Mayo Clinic, Rochester, MN, USA

    Alejandro A. Rabinstein

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  1. Daniel Agustín Godoy
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  2. Mario Di Napoli
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  3. Alejandro A. Rabinstein
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Correspondence to Daniel Agustín Godoy.

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Godoy, D.A., Di Napoli, M. & Rabinstein, A.A. Cerebral Fat Embolism: Recognition, Complications, and Prognosis. Neurocrit Care 29, 358–365 (2018). https://doi.org/10.1007/s12028-017-0463-y

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  • DOI: https://doi.org/10.1007/s12028-017-0463-y

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