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Human neutrophil peptide-1 decreases during ageing in selected Mexican population

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Abstract

Antimicrobial peptide innate immunity plays a central role in the susceptibility to infectious diseases, as has been described extensively in different settings. However, the role that these molecules play in the immunity mediated by polymorphonuclear phagocytes as part of the innate immunity of ageing individuals has not been described. In the present study, we addressed the question whether antimicrobial activity in polymorphonuclear cells from elderly individuals was altered in comparison with young adults. We compared phagocytosis index, bacterial killing efficiency, myeloperoxidase activity and cathelicidin expression. Results showed that there were no statistical differences among groups. However, human neutrophil peptide-1 (HNP-1) was decreased in the elderly individuals group. Results suggest that the decreased HNP-1 production in the polymorphonuclear phagocytes form elderly individuals might have an important participation in the increased susceptibility to infectious diseases.

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Acknowledgments

This work was supported by the National Council of Science and Technology in Mexico-CONACyT (FOSSIS-2011-1-161735). JECD performed the experiments analysed data and helped to write the manuscript. JdA, IFL, PML, RGA and JAEM performed the experiments and collected the samples. BRS designed the study, obtained financial support, analysed data and wrote the paper. Special thanks to ISSSTE Senior Association for their enthusiastic participation in the study. We thank the clinical laboratory staff at the Emilio Varela Lujan Hospital of Zacatecas.

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Authors and Affiliations

  1. Medical Research Unit of Zacatecas, Mexican Institute of Social Security, UIMZ-IMSS, Interior de la alameda # 45 col centro, Zacatecas, Mexico

    Bruno Rivas-Santiago, Julio E. Castañeda-Delgado, Jeny de Haro-Acosta, Flor Torres-Juarez, Isabel Frausto-Lujan & Paulina Marin-Luevano

  2. Catedras-CONACyT, National Council of Science and Technology (CONACyT), Mexico City, Mexico

    Roberto González-Amaro & Jose A. Enciso-Moreno

  3. Department of Immunology, Faculty of Medicine, Autonomous University of San Luis Potosí, San Luis Potosi, Mexico

    Roberto González-Amaro

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  1. Bruno Rivas-Santiago
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  2. Julio E. Castañeda-Delgado
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Correspondence to Bruno Rivas-Santiago.

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Bruno Rivas-Santiago and Julio E. Castañeda-Delgado are joint authors.

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Rivas-Santiago, B., Castañeda-Delgado, J.E., de Haro-Acosta, J. et al. Human neutrophil peptide-1 decreases during ageing in selected Mexican population. Immunol Res 64, 445–454 (2016). https://doi.org/10.1007/s12026-015-8689-2

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  • DOI: https://doi.org/10.1007/s12026-015-8689-2

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