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Peripheral regulation of T cells by dendritic cells during infection

  • IMMUNOLOGY AT THE UNIVERSITY OF IOWA
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Abstract

It is well accepted that T cell responses are integral in providing protection during pathogenic infections. In numerous tissues, T cell responses are generated to combat infection. Typically, these T cell responses are primed in draining lymph nodes (LN) by dendritic cells (DC) that have migrated from the infected tissue. Previously, it was thought that after the initial encounter between DC and T cells in the LN, the T cells underwent a programmed response. However, it has become increasingly clear that direct interactions between DCs and T cells in infected, peripheral tissues can modulate the activation, effector function, tissue residence, and memory responses of these T cells. This review will highlight the contribution of local, direct DC: T cell interactions to the regulation of T cell responses in various tissues during inflammation and infection .

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Acknowledgments

We thank Emma E. Hornick for her critical reading of this manuscript. This work was supported by National Institutes of Health awards AI071085 (to K.L.L.), T32 AI007533 (to E.A.H.), and T32 AI007485 (to E.A.H.).

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  1. Department of Pathology and Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA, 52242, USA

    Emily A. Hemann & Kevin L. Legge

  2. Department of Pathology, 1028ML, University of Iowa, 200 Hawkins Drive, Iowa City, IA, 52242, USA

    Kevin L. Legge

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Hemann, E.A., Legge, K.L. Peripheral regulation of T cells by dendritic cells during infection. Immunol Res 59, 66–72 (2014). https://doi.org/10.1007/s12026-014-8530-3

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