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Expression of FcεRIα and tryptase in human lung tissue during drug-induced anaphylactic death

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Abstract

The diagnosis of drug-induced anaphylactic death is an important component of forensic medicine. The purpose of this study was to explore the expression of FcεRIα and tryptase in human lung tissue during drug-induced anaphylactic death and its value for forensic medicine. The expression of FcεRIα and tryptase in lung tissues of the drug-induced anaphylactic death group (n = 30) and control group (who died due to sudden cardiac death, falling from a height, or traffic accidents, n = 30) was detected by immunohistochemistry and immunofluorescence staining. The difference in FcεRIα and tryptase expression in the lung tissue between the drug-induced anaphylactic death group and the control group was statistically significant (p < 0.05). The levels of FcεRIα and tryptase expression greatly increased in the lung tissue of the drug-induced anaphylactic death group, which may provide morphological evidence and a reference for the diagnosis of drug-induced anaphylactic death in forensic medicine.

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Acknowledgements

This work was supported by the Hongqi Research Fund of Mudanjiang Medical College (grant number 2018HQ-02), Basic scientific research cost scientific research project of University in Heilongjiang Province (grant number 2018-KYYWFMY-0065), National Natural Science Foundation of China (grant number 81172904), the Natural Science Foundation of Liaoning Province, China (grant number 2015020511), the Natural Science Foundation of Liaoning Province, China (grant number 201102299), the Shenyang Scientifc and Technological Plan, China (grant number F11-264-1-67), the Doctoral Research Startup Foundation of Liaoning Province, China (grant number 2019-BS-145), and the Foundation of Education Department of Liaoning Province, China (grant number QN2019037). We would like to thank TVGFT4BM [www.aje.com] for language editing.

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Author notes

  1. Chunmei Feng and Chaoxu Zhang contributed equally to this work.

  2. Guohua Zhang and Hao Yu authors contributed equally to the work.

Authors and Affiliations

  1. School of Forensic Medicine, China Medical University, Shenyang, 110122, P.R. China

    Chunmei Feng, Pengfei Wang, Xiaolong Wang, Guohua Zhang & Hao Yu

  2. Department of Hematology, The First Hospital of China Medical University, Shenyang, 110001, P.R. China

    Chaoxu Zhang

  3. Department of Pathology, Mudanjiang Medical College, Mudanjiang, Heilongjiang, 157011, P.R. China

    Chunmei Feng

  4. Economic and Technological Development Zone Branch of Shenyang Public Security Bureau, Shenyang, 110122, P.R. China

    Jiabin You

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  1. Chunmei Feng
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  4. Xiaolong Wang
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Correspondence to Guohua Zhang or Hao Yu.

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Samples were obtained and analyzed after approval from the Ethics Committee of China Medical University (no. [2018] 065).

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Feng, C., Zhang, C., Wang, P. et al. Expression of FcεRIα and tryptase in human lung tissue during drug-induced anaphylactic death. Forensic Sci Med Pathol 17, 547–552 (2021). https://doi.org/10.1007/s12024-021-00405-w

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