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Testicular morphology in hypogonadotropic hypogonadism after the abuse of anabolic steroids

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Abstract

Hypogonadism in men results from the failure of the testes to produce physiological levels of testosterone and a normal number of spermatozoa due to a disruption of the hypothalamic-pituitary-testicular axis. An example of secondary hypogonadism as a result of anabolic steroid abuse is presented with the case report of a man who committed suicide after a history of aggressive behavior and physical abuse of his wife. The autopsy revealed shrunken testicles, with more than 30% of parenchymatous sclerosis, absent spermatogenesis, and very few Leydig cells detected only by immunohistochemistry. A low-specific immunochemical analysis revealed a very high level of total testosterone (serum 109.8 nmol/L; urine 81.2 nmol/L). A more accurate analysis confirmed an overdose of synthetic anabolic steroids. Doctors in different medical areas should be alerted to chronic abusers of synthetic anabolic steroids among the growing number of recreational athletes.

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References

  1. Bhasin S, Cunningham GR, Hayes FJ, Matsumoto AM, Snyder PJ, Swerdloff RS, et al. Testosterone therapy in adult men with androgen deficiency syndromes: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2010;95:2536–59.

    Article  CAS  Google Scholar 

  2. Bhasin S, Basaria S. Diagnosis and treatment of hypogonadism in men. Best Pract Res Clin Endocrinol Metab. 2011;25:251–70.

    Article  CAS  Google Scholar 

  3. Harman SM, Metter EJ, Tobin JD, Pearson J, Blackman MR. Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore longitudinal study of aging. J Clin Endocrinol Metab. 2001;86:724–31.

    Article  CAS  Google Scholar 

  4. Wu FCW, Tajar A, Beynon JM, Pye SR, Silman AJ, Finn JD, et al. Identification of late-onset hypogonadism in middle-aged and elderly men. N Engl J Med. 2010;363:123–35.

    Article  CAS  Google Scholar 

  5. Nistal M, Paniagua R. Non-neoplastic diseases of the testis. In: Bostwick DG, Cheng L, editors. Urologic surgical pathology. 2nd ed. Amsterdam: Elsevier; 2008. p. 615–755.

    Google Scholar 

  6. Young B, Heath JW. Wheater's functional histology. 4th ed. London: Churchill Livingstone; 2000.

    Google Scholar 

  7. Pinter B. Sex hormones and their biological effects. Med Razgl. 2001;40:415–21.

    CAS  Google Scholar 

  8. de Souza GL, Hallak J. Anabolic steroids and male infertility: a comprehensive review. BJU Int. 2011;108:1860–5.

    Article  Google Scholar 

  9. Karila T, Hovatta O, Seppala T. Concomitant abuse of anabolic androgenic steroids and human chorionic gonadotrophin impairs spermatogenesis in power athletes. Int J Sports Med. 2004;25:257–63.

    Article  CAS  Google Scholar 

  10. Jan Z, Pfeifer M, Zorn B. Reversible testosterone-induced azoospermia in a 45-year-old man attending an infertility outpatient clinic. Andrologia. 2012;44(Suppl 1):823–5.

    Article  Google Scholar 

  11. Nagata S, Kurosawa M, Mima K, Nambo Y, Fujii Y, Watanabe G, et al. Effects of anabolic steroid (19-nortestosterone) on the secretion of testicular hormones in the stallion. J Reprod Fertil. 1999;115:373–9.

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Institute of Forensic Medicine, Faculty of Medicine, University of Ljubljana, Korytkova 2, 1000, Ljubljana, Slovenia

    Armin Alibegović

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  1. Armin Alibegović
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Correspondence to Armin Alibegović.

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Alibegović, A. Testicular morphology in hypogonadotropic hypogonadism after the abuse of anabolic steroids. Forensic Sci Med Pathol 14, 564–567 (2018). https://doi.org/10.1007/s12024-018-0015-6

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  • DOI: https://doi.org/10.1007/s12024-018-0015-6

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