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Epithelioid Angiosarcoma of the Thyroid: Report of a Case from an Italian Non-Alpine Area and Review of the Literature

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Abstract

Epithelioid angiosarcoma of the thyroid is a rare mesenchymal neoplasm, mainly described in the Alpine area. This lesion was initially considered an anaplastic carcinoma, but immunohistochemical and ultrastructural features have proven the endothelial differentiation of tumor cells. In fact, the peculiarity of this tumor concerns the expression of low-molecular weight cytokeratins by neoplastic cells of endothelial origin. We describe a case of epithelioid angiosarcoma of the thyroid occurred in a 73-year-old woman from an Italian non-Alpine area, and a review of non-Alpine primary thyroid epitheliod angiosarcoma is presented.

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References

  1. Rosai J, Carcangiu ML, DeLellis RA. Sarcomas. In: Atlas of tumor pathology. Tumors of the thyroid gland, 3rd series

  2. Weiss SW, Lasota J, Miettinen MM. Vascular tumours. In: Fletcher CDM, Unni KK, Mertens F. WHO classification of tumours. Tumours of soft tissue and bone, 4th ed.

  3. Eusebi V. Tumours of the thyroid and parathyroid In: DeLellis RA, Ronald ADL, Ricardo VL. WHO classification of tumours. Tumours of endocrin organs, 8th ed.

  4. Mills SE, Gaffey MJ, Watts JC, Swanson PE, Wick MR, LiVolsi VA, Nappi O, Weiss LM. Angiomatoid carcinoma and ‘angiosarcoma’ of thyroid gland: a spectrum of endothelial differentiation. Am J Clin Pathol 102: 322–330, 1994

    CAS  PubMed  Google Scholar 

  5. Maiorana A, Collina G, Cesinaro AM, Fano RA, Eusebi V. Angiomatoid carcinoma of the thyroid: clinicopathological analysis of seven cases from non-Alpine areas. Wirchows Arch 429: 131–137, 1996

    CAS  Google Scholar 

  6. Eusebi V, Carcangiu ML, Dina R, Rosai J. Keratin-positive epithelioid angiosarcoma of thyroid. A report of four cases. Am J Surg Pathol 14: 737–747, 1990

    Article  CAS  PubMed  Google Scholar 

  7. Papotti M, Arrondini M, Tavaglione V, Veltri A, Volante M. Diagnostic controversies in vascular proliferations of the thyroid gland. Endocr Pathol 19: 175–183, 2008

    Article  PubMed  Google Scholar 

  8. Petronella P, Scorzelli M, Luise R, Iannaci G, Sapere P, Ferretti M, Costanzo RM, Freda F, Canonico S, Rossiello R . Primary thyroid angiosarcoma: an unusual localization. World J Surg Oncol 10: 73, 2012

    Article  PubMed Central  PubMed  Google Scholar 

  9. Kalitova P, Plazak J, Kodet R, Astl J. Angiosarcoma of the thyroid. Eur Arch Otorhinolaryngol 266: 903–905, 2009

    Article  PubMed  Google Scholar 

  10. Tanda F, Massarelli G, Bosincu L, Cossu A. Angiosarcoma of the thyroid: a light, electron microscopic and histoimmunological study. Human Pathol 19: 742–745, 1988

    Article  CAS  Google Scholar 

  11. Goh SG, Chuah KL, Goh HK, Chen YY. Two cases of epithelioid angiosarcoma involving the thyroid and a brief review of non-Alpine epithelioid angiosarcoma of the thyroid. Arch Pathol Lab Med 127: 70–73, 2003

    Google Scholar 

  12. Bisceglia M, Vairo M, Tardio G, Scaramuzzi G, Zingrillo M. L’angiosarcoma primitivo della tiroide. Presentazione di un caso (“varietà epitelioidea”) e problematiche nosologiche. Pathologica 87: 154–161, 1995

    CAS  PubMed  Google Scholar 

  13. Ryska A, Ludvikova M, Szepe P, Boor A. Epithelioid haemangiosarcoma of the thyroid gland. Report of six cases from a non-Alpine region. Histopathology 44: 40–46, 2004

    Article  CAS  PubMed  Google Scholar 

  14. Lamovec J, Zidar A, Zidanik B. Epithelioid angiosarcoma of the thyroid gland. Arch Pathol Lab Med 118: 642–646, 1994

    CAS  PubMed  Google Scholar 

  15. Binesh F, Akhavan A, Navabii H, Dadgarnia MH, Zand V. Primary angiosarcoma of the thyroid gland in an young Iranian woman. BMJ Case rep 2011 Jun 30, 2011

  16. Chan YF, Ma L, Boey JH, Yeung HY. Angiosarcoma of the thyroid. An immunoistochemical and ultrastructural study of a case in a Chinese patient. Cancer 57: 2381–2388, 1986

    Article  CAS  PubMed  Google Scholar 

  17. Ortiz J, Villabona C, Bengoechea O. Primary epithelioid angiosarcoma of the thyroid: an infrequent malignant tumor. Endocrinol Nutr. 55: 181–183, 2008

    Article  PubMed  Google Scholar 

  18. Innaro N, Succurro, E, Tomaino G, Arturi F. Nonalpine thyroid angiosarcoma in a patient with Hashimoto thyroiditis. Case Rep Oncol Med 2013: 901246

  19. Gouveia P, Silva C, Magalhaes F, Santos C, Guerreiro E, Santos F, Gomes T. Non-Alpine thyroid angiosarcoma. Int J Surg Case Rep 4: 524–527, 2013

    Article  PubMed Central  PubMed  Google Scholar 

  20. Prather J, Mehrotra S. Thyroid nodule. JAMA Otolaryngol Head Neck Surg 140: 469–470, 2014

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Pathological Anatomy Unit, Department of Surgery and Translational Medicine, University of Florence, L.go Brambilla 3, 50134, Florence, Italy

    Matteo Rotellini, Vania Vezzosi & Simonetta Bianchi

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  1. Matteo Rotellini
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  2. Vania Vezzosi
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  3. Simonetta Bianchi
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Correspondence to Matteo Rotellini.

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Rotellini, M., Vezzosi, V. & Bianchi, S. Epithelioid Angiosarcoma of the Thyroid: Report of a Case from an Italian Non-Alpine Area and Review of the Literature. Endocr Pathol 26, 152–156 (2015). https://doi.org/10.1007/s12022-015-9372-9

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