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Radioiodine whole body scan pitfalls in differentiated thyroid cancer

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Abstract

Purpose

whole body scan (WBS) performed following diagnostic or therapeutic administration of I-131 is useful in patients with differentiated thyroid carcinoma. However, it can be falsely positive in various circumstances. We aimed to report a series of pitfalls in a clinical perspective.

Methods

A search in the database PubMed utilizing the following terms: “false radioiodine uptake” and “false positive iodine 131 scan” has been made in January 2023. Among the 346 studies screened, 230 were included in this review, with a total of 370 cases collected. Physiological uptakes were excluded. For each patient, sex, age, dose of I-131 administered, region and specific organ of uptake and cause of false uptake were evaluated.

Results

370 cases of false radioiodine uptake were reported, 19.1% in the head-neck region, 34.2% in the chest, 14.8% in the abdomen, 20.8% in the pelvis, and 11.1% in the soft tissues and skeletal system. The origin of false radioiodine uptake was referred to non-tumoral diseases in 205/370 cases (55.1%), benign tumors in 108/370 cases (29.5%), malignant tumors in 25/370 cases (6.7%), and other causes in 32/370 cases (8.7%).

Conclusions

WBS is useful in the follow-up of patients with differentiated thyroid carcinoma, however it can be falsely positive in various circumstances. For this reason, it is critically important to correlate the scintigraphic result with patient’s medical history, serum thyroglobulin levels, additional imaging studies and cytologic and/or histologic result.

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References

  1. B.R. Haugen et al. 2015 American Thyroid Association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: the American Thyroid Association guidelines task force on thyroid nodules and differentiated thyroid cancer. Thyroid 26, 1–133 (2016)

    Article  PubMed  PubMed Central  Google Scholar 

  2. V. Triggiani et al. False positive diagnosis on (131)iodine whole-body scintigraphy of differentiated thyroid cancers. Endocrine 53, 626–635 (2016)

    Article  CAS  PubMed  Google Scholar 

  3. A. Oral, B. Yazıcı, C. Eraslan, Z. Burak, Unexpected false-positive i-131 uptake in patients with differentiated thyroid carcinoma. Mol. Imaging. Radionucl. Ther. 27, 99–106 (2018)

    Article  PubMed  PubMed Central  Google Scholar 

  4. J.-R. Oh, B.-C. Ahn, False-positive uptake on radioiodine whole-body scintigraphy: physiologic and pathologic variants unrelated to thyroid cancer. Am. J. Nucl. Med Mol. Imaging. 2, 362–385 (2012)

    PubMed  PubMed Central  Google Scholar 

  5. R. Ciappuccini et al. Radioiodine sinus uptake related to mucosal thickening or aspergilloma: a case series of an unrecognized event well evidenced by SPECT/CT. Cancer Imaging 17, 1–6 (2017)

    Article  Google Scholar 

  6. S.M. Bakheet, M.M. Hammami, J. Powe, S. Larsson, Radioiodine uptake in the head and neck. Endocr. Pract. 6, 37–41 (2000)

    Article  CAS  PubMed  Google Scholar 

  7. J.J. Duque et al. False-positive I-131 whole-body scan in follicular thyroid carcinoma caused by frontal sinus mucocele. Clin. Nucl. Med. 25, 137–138 (2000)

    Article  CAS  PubMed  Google Scholar 

  8. S.M. Bakheet, J. Powe, M.M. Hammami, Radioiodine uptake in the chest. J. Nucl. Med. 38, 984–986 (1997)

    CAS  PubMed  Google Scholar 

  9. Y.B. Garger, M. Winfeld, K. Friedman, M. Blum, In thyroidectomized thyroid cancer patients, false-positive I-131 whole body scans are often caused by inflammation rather than thyroid cancer. J. Investig. Med. High Impact Case Rep. 4, 2324709616633715 (2016)

    PubMed  PubMed Central  Google Scholar 

  10. P.O. Kara, E.C. Gunay, A. Erdogan, Radioiodine contamination artifacts and unusual patterns of accumulation in whole-body I-131 imaging: a case series. Int. J. Endocrinol. Metab. 12, e9329 (2014)

    Article  Google Scholar 

  11. S.S. Wadhwa, R. Mansberg, Benign oral disease as a cause of false-positive iodine-131 scans. Clin. Nucl. Med. 23, 747–749 (1998)

    Article  CAS  PubMed  Google Scholar 

  12. S. Kim, C.H. Park, S.N. Yoon, K. Hwang, A false-positive I-131 whole-body scan in chronic parotitis: a case report. Clin. Nucl. Med. 26, 536–537 (2001)

    Article  CAS  PubMed  Google Scholar 

  13. M.R. Carlisle, I.R. McDougall, Dramatic parotid uptake of I-131 on a diagnostic whole-body scan. Clin. Nucl. Med. 25, 895–897 (2000)

    Article  CAS  PubMed  Google Scholar 

  14. D.I. Glazer et al. SPECT/CT evaluation of unusual physiologic radioiodine biodistributions: pearls and pitfalls in image interpretation. Radiographics 33, 397–418 (2013)

    Article  PubMed  Google Scholar 

  15. I.S. Kolla, N.P. Alazraki, N.B. Watts, Sialadenitis mimicking metastatic thyroid carcinoma. Clin. Nucl. Med. 14, 564–566 (1989)

    Article  CAS  PubMed  Google Scholar 

  16. M. Zhang, Y. Zhang, W. Huang, B. Li, False-positive 131I uptake by the temporomandibular joint effusion. Clin. Nucl. Med. 38, 823–825 (2013)

    Article  PubMed  Google Scholar 

  17. D. Giuffrida, M.C. Fornito, G. Pellegriti, C. Regalbuto, G. Vigneri, False positive 131I total body scan due to bilateral polycystic renal disease. J. Endocrinol. Investig. 20, 342–344 (1997)

    Article  CAS  Google Scholar 

  18. S.C. Ong, D.N.C. Eng, F.X. Sundram, L.L. Chan, A novel case of false-positive I-131 whole-body scan in thyroid carcinoma caused by subdural hematoma. Clin. Nucl. Med. 29, 164–166 (2004)

    Article  PubMed  Google Scholar 

  19. M. Lee, Y.K. Lee, T.J. Jeon, C.S. Park, Y.H. Ryu, 131I uptake in intraosseous hemangioma of the skull: mimicking a bone metastasis in thyroid cancer. Clin. Nucl. Med. 39, 990–992 (2014)

    Article  PubMed  Google Scholar 

  20. H. Wolff, D.J. Breda, N. Da Silva, A.A. Hartmann, False-positive I-131 deposition in a parotid gland duct ectasia. Clin. Nucl. Med. 23, 257–259 (1998)

    Article  CAS  PubMed  Google Scholar 

  21. M.S. Kipper, L.D. Krohn, Increased submandibular gland uptake on thyroid scintigraphy due to Wharton’s duct stone. Clin. Nucl. Med. 21, 881 (1996)

    Article  CAS  PubMed  Google Scholar 

  22. S. Yuoness, I. Rachinsky, A.A. Driedger, T.Z. Belhocine, Differentiated thyroid cancer with epiphora: detection of nasolacrimal duct obstruction on I-131 SPECT/CT. Clin. Nucl. Med. 36, 1149–1152 (2011)

    Article  PubMed  Google Scholar 

  23. N. Filizoğlu, K. Öksüzoğlu, S. Özgüven, O. Buğdaycı, T.Y. Erdil, Nasolacrimal duct obstruction on 131I SPECT/CT: atypical false-positive paranasal radioiodine uptake as a complication of single-dose RAI treatment. Mol. Imaging Radionucl. Ther. 31, 234–236 (2022)

    Article  PubMed  PubMed Central  Google Scholar 

  24. S. Ilgan, Y. Narin, N. Arslan, A. Aksu, H. Bayhan, Warthin’s tumor and I-131 body scan. Clin. Nucl. Med. 24, 721–722 (1999)

    Article  CAS  PubMed  Google Scholar 

  25. M. Caglar, M. Tuncel, A. Usubutun, Increased uptake on I-131 whole-body scintigraphy in Warthin tumor despite false-negative Tc-99m pertechnetate salivary gland scintigraphy. Clin. Nucl. Med. 28, 945–946 (2003)

    Article  PubMed  Google Scholar 

  26. Y. Zhang, S. Minoshima, SPECT/CT demonstrating 131I retention in Warthin tumor on thyroid cancer survey scan. Clin. Nucl. Med. 38, e372–e373 (2013)

    Article  PubMed  Google Scholar 

  27. H. Broekhuizen-de Gast, H. van Isselt, M. Roef, M. Lam, Oncocytoma of the parotid gland causing false-positive result on I-131 whole-body scintigraphy. Clin. Nucl. Med. 36, 701–703 (2011)

    Article  PubMed  Google Scholar 

  28. A.V. Chudgar, J.C. Shah, Pictorial review of false-positive results on radioiodine scintigrams of patients with differentiated thyroid cancer. Radiographics 37, 298–315 (2017)

    Article  PubMed  Google Scholar 

  29. Q. Jia et al. Retrospective imaging study on the diagnosis of pathological false positive iodine-131 scans in patients with thyroid cancer. Exp. Ther. Med. 10, 1995–2001 (2015)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. P. RA et al. Uptake of 131I by a papillary meningioma. AJR. Am. J. Roentgenol. 129, 349–350 (1977)

    Article  Google Scholar 

  31. P. Sinha, G.R. Conrad, M. Holzhauer, Incidental detection of a falx meningioma on post-therapy radioiodide whole-body imaging. Clin. Nucl. Med. 27, 916–917 (2002)

    Article  PubMed  Google Scholar 

  32. B.J. Noordman, E. Comans, P. Lips, R.N. Rinkel, False-positive uptake of 124I in a laryngeal cyst mimicking thyroid remnant after thyroidectomy and 131i therapy for follicular thyroid carcinoma. Clin. Nucl. Med. 39, 898–899 (2014)

    Article  PubMed  Google Scholar 

  33. R.M. García-Moreno et al. Orbital radioiodine uptake on scintigraphy in a patient with thyroid cancer. Eur. Thyroid J. 8, 221–224 (2019)

    Article  PubMed  PubMed Central  Google Scholar 

  34. C. Naik, S. Basu, Mucoepidermoid parotid gland tumor found on follow-up radioiodine scan for differentiated papillary thyroid cancer. J. Nucl. Med. Technol. 45, 116–118 (2017)

    Article  PubMed  Google Scholar 

  35. G.A. Kirk, E.E. Schulz, Post-laryngectomy localization of I-131 at tracheostomy site on a total body scan. Clin. Nucl. Med. 9, 409–411 (1984)

    Article  CAS  PubMed  Google Scholar 

  36. K.B. Ain, W.J. Shih, False-positive I-131 uptake at a tracheostomy site. Discernment with Tl-201 imaging. Clin. Nucl. Med. 19, 619–621 (1994)

    Article  CAS  PubMed  Google Scholar 

  37. T. Thientunyakit, False-positive 131I whole-body scan in well-differentiated thyroid cancer patient with respiratory bronchiolitis. Clin. Nucl. Med. 38, 730–734 (2013)

    Article  PubMed  Google Scholar 

  38. A.P. Demidowich, A. Kundu, J.C. Reynolds, F.S. Celi, False-positive radioactive iodine uptake mimicking miliary lung metastases in a patient affected by papillary thyroid cancer and IgA deficiency. Nucl. Med. Mol. Imaging 50, 270–272 (2016)

    Article  PubMed  Google Scholar 

  39. F. Calabria et al. 131I Uptake in bronchiectasis detected by single photon emission computed tomography/computed tomography during follow-up of thyroid cancer. Indian J. Nucl. Med. 34, 235–236 (2019)

    Article  PubMed  PubMed Central  Google Scholar 

  40. B. Yazici, A. Oral, Ş. Alçiçek, I. Tamsel, A. Akgün, False-positive I-131 uptakes at pulmonary wedge-resection site and soft tissue lateral to the femoral heads in a patient with papillary thyroid carcinoma. Mol. Imaging Radionucl. Ther. 28, 34–37 (2019)

    Article  PubMed  PubMed Central  Google Scholar 

  41. R. Espírito Santo, P. Marques, M. João Bugalho, False-positive uptake on radioiodine whole-body scan due to bronchiectasis. BMJ Case Rep. 2015, bcr2015213169 (2015)

    Article  PubMed  PubMed Central  Google Scholar 

  42. C. Jia, R. Moadel, L.M. Freeman, Focal thoracic uptake mimicking lung metastasis on 131I post-therapy whole-body scan in patients with thyroid carcinoma. Clin. Nucl. Med. 39, 360–362 (2014)

    Article  PubMed  Google Scholar 

  43. A. Gargya, E. Chua, Focal bronchiectasis causing abnormal pulmonary radioiodine uptake in a patient with well-differentiated papillary thyroid carcinoma. Case Rep. Endocrinol. 2012, 1–3 (2012)

    Article  Google Scholar 

  44. I. Jong, K. Taubman, S. Schlicht, Bronchiectasis simulating pulmonary metastases on iodine-131 scintigraphy in well-differentiated thyroid carcinoma. Clin. Nucl. Med. 30, 688–689 (2005)

    Article  PubMed  Google Scholar 

  45. L. Buton et al. False-positive iodine-131 whole-body scan findings in patients with differentiated thyroid carcinoma: report of 11 cases and review of the literature. Ann. Endocrinol. 74, 221–230 (2013)

    Article  Google Scholar 

  46. H.C. Song, Y.J. Heo, S.M. Kim, H.S. Bom, Iodine-131 uptake in focal bronchiectasis mimicking metastatic thyroid cancer. Clin. Nucl. Med. 28, 351–352 (2003)

    Article  PubMed  Google Scholar 

  47. T. Mack, J. Miller, E. Silverman, Single-photon emission computed tomography/computed tomography iodine-131 uptake of bronchiectasis masquerading as metastatic thryroid disease. Indian J. Nucl. Med. 30, 292–293 (2015)

    Article  PubMed  PubMed Central  Google Scholar 

  48. V. Triggiani, M. Moschetta, V.A. Giagulli, B. Licchelli, E. Guastamacchia, Diffuse 131I lung uptake in bronchiectasis: a potential pitfall in the follow-up of differentiated thyroid carcinoma. Thyroid 22, 1287–1290 (2012)

    Article  CAS  PubMed  Google Scholar 

  49. R. Hoschl, D.H.L. Choy, B. Gandevia, Iodine-131 uptake in inflammatory lung disease: a potential pitfall in treatment of thyroid carcinoma. J. Nucl. Med. 29, 701–706 (1988)

    CAS  PubMed  Google Scholar 

  50. S.M. Bakheet, M.M. Hammami, J. Powe, M. Bazarbashi, H. Al Suhaibani, Radioiodine uptake in inactive pulmonary tuberculosis. Eur. J. Nucl. Med. 26, 659–662 (1999)

    Article  CAS  PubMed  Google Scholar 

  51. R. Ranade, S. Pawar, A. Mahajan, S. Basu, Unusual false positive radioiodine uptake on (131)I whole body scintigraphy in three unrelated organs with different pathologies in patients of differentiated thyroid carcinoma: a case series. World J. Nucl. Med. 15, 137–141 (2016)

    Article  PubMed  PubMed Central  Google Scholar 

  52. M.K. Picolos, M. Habra, A. Safdar, N.J. Sarlis, Inactive pulmonary tuberculosis mimicking metastasis from papillary thyroid carcinoma in diagnostic radioiodine whole-body scintigraphy. Thyroid 15, 1105–1106 (2005)

    Article  PubMed  Google Scholar 

  53. J.S. Pina et al. Inflammatory diseases of the lung causing false-positive 131iodine whole body scans in the evaluation of papillary thyroid carcinoma. Two case reports. Chest 110, 565–567 (1996)

    Article  CAS  PubMed  Google Scholar 

  54. B.C. Ahn, S.W. Lee, J. Lee, C. Kim, Pulmonary aspergilloma mimicking metastasis from papillary thyroid cancer. Thyroid 21, 555–558 (2011)

    Article  PubMed  Google Scholar 

  55. K.K. Karuppusamy, J. Antony, E.R. Radhakrishnan, A.S. Shinto, Image findings of a false positive radioactive iodine-131 uptake mimicking metastasis in pulmonary aspergillosis identified on single photon emission computed tomography-computed tomography. J. Cancer Res. Ther. 11, 656 (2015)

    Article  CAS  PubMed  Google Scholar 

  56. C.F. Nava et al. Reappraising the diagnostic accuracy of post-treatment whole-body scans for differentiated thyroid carcinoma. Horm. Metab. Res. 52, 834–840 (2020)

    Article  CAS  PubMed  Google Scholar 

  57. D. Posocco, B. Kamat, S. Dadparvar, False-positive 123I-uptake mimics metastatic lung disease in a patient with interstitial lung disease secondary to scleroderma. Clin. Nucl. Med. 47, 79–80 (2022)

    Article  PubMed  Google Scholar 

  58. K. Licht, C. Kroegel, K. Katenkamp, M. Freesmeyer, Anthracofibrosis manifesting as false-positive iodine accumulation in a patient with recent history of thyroid carcinoma. Clin. Nucl. Med. 41, 336–337 (2016)

    Article  PubMed  Google Scholar 

  59. E.G. Spinapolice et al. Pulmonary sequestration: a (131)I whole body scintigraphy false-positive result. Ann. Nucl. Med. 28, 683–687 (2014)

    Article  PubMed  Google Scholar 

  60. M. Lejeune et al. [Iodine 131 uptake by a bronchogenic cyst in a patient with differentiated carcinoma of the thyroid gland]. Presse Med. 29, 1345–1347 (2000)

    CAS  PubMed  Google Scholar 

  61. W. Langsteger et al. False-positive radioiodine uptake in lung carcinoma [7]. J. Nucl. Med. 35, 2056–2057 (1994)

    CAS  PubMed  Google Scholar 

  62. W. Langsteger, P. Lind, P. Költringer, A. Beham, O. Eber, Misinterpretation of iodine uptake in papillary thyroid carcinoma and primary lung adenocarcinoma. J. Cancer Res. Clin. Oncol. 116, 8–12 (1990)

    Article  CAS  PubMed  Google Scholar 

  63. Y.L. Lu et al. Primary lung cancer with radioiodine avidity: a thyroid cancer cohort study. World J. Clin. cases 9, 71–80 (2021)

    Article  PubMed  PubMed Central  Google Scholar 

  64. M. Fernandez Ulloa, H.R. Maxon, S. Mehta, L.J. Sholiton, Iodine 131 uptake by primary lung adenocarcinoma: misinterpretation of 131I scan. JAMA J. Am. Med. Assoc. 236, 857–858 (1976)

    Article  CAS  Google Scholar 

  65. B.G. Haubold-Reuter, U. Landolt, G.K.V. Schulthess, Bronchogenic carcinoma mimicking metastatic thyroid carcinoma. J. Nucl. Med. 34, 809–811 (1993)

    CAS  PubMed  Google Scholar 

  66. T. Misaki et al. Radioiodine uptake by squamous-cell carcinoma of the lung. J. Nucl. Med. 35, 474–475 (1994)

    CAS  PubMed  Google Scholar 

  67. G. Malhotra et al. Bronchoalveolar carcinoma of lung masquerading as iodine avid metastasis in a patient with minimally invasive follicular carcinoma of thyroid. Clin. Nucl. Med. 33, 26–29 (2008)

    Article  PubMed  Google Scholar 

  68. J. Acosta, R. Chitkara, F. Khan, V. Azueta, L. Silver, Radioactive iodine uptake by a large cell undifferentiated bronchogenic carcinoma. Clin. Nucl. Med. 7, 368–369 (1982)

    Article  CAS  PubMed  Google Scholar 

  69. M.H. Sohn et al. Radioiodine uptake by metastatic nonthyroidal adenocarcinoma of the lung in a patient with papillary thyroid carcinoma. Clin. Nucl. Med. 30, 269–270 (2005)

    Article  PubMed  Google Scholar 

  70. I.F. Ruel et al. Pulmonary metastasis of struma ovarii: a case report. Clin. Nucl. Med. 35, 692–694 (2010)

    Article  PubMed  Google Scholar 

  71. C. Nascimento, B. Bridji, C. Dejax, M. Schlumberger, S. Leboulleux, Thoracic 131I uptake after previous pneumonectomy in patients treated for differentiated thyroid cancer. Clin. Nucl. Med. 37, 587–590 (2012)

    Article  PubMed  Google Scholar 

  72. S.Y. Naddaf, M.F. Akisik, W.S. Omar, I. Young, H.M. Abdel-Dayem, I-123 uptake in the chest wall after needle biopsy of a pulmonary nodule. A cause for false-positive I-123 uptake. Clin. Nucl. Med. 22, 572–573 (1997)

    Article  CAS  PubMed  Google Scholar 

  73. A. Abhyankar, S. Basu, Thymus uptake of 131I in patients with differentiated thyroid carcinoma: Three different case scenarios and patterns of uptake and the importance of its recognition in thyroid cancer practice. J. Cancer Res. Ther. 11, 648 (2015)

    Article  PubMed  Google Scholar 

  74. M. Haghighatafshar, F. Farhoudi, Incidentally visualization of the thymus on whole-body iodine scintigraphy: report of 2 cases and review of the latest insights. Medicine 94, e1015 (2015)

    Article  PubMed  PubMed Central  Google Scholar 

  75. M.E. Mello, R.C. Flamini, R. Corbo, M. Mamede, Radioiodine concentration by the thymus in differentiated thyroid carcinoma: report of five cases. Arq. Bras. Endocrinol. Metabol. 53, 874–879 (2009)

    Article  PubMed  Google Scholar 

  76. M. Salvatori, I. Saletnich, V. Rufini, L. Troncone, Unusual false-positive radioiodine whole-body scans in patients with differentiated thyroid carcinoma. Clin. Nucl. Med. 22, 380–384 (1997)

    Article  CAS  PubMed  Google Scholar 

  77. I.E. Veronikis, S. Peter, L.E. Braverman, Thymic uptake of Iodine-131 in the anterior mediastinum. J. Nucl. Med. 37, 991–992 (1996)

    CAS  PubMed  Google Scholar 

  78. T. Michigishi et al. Visualization of the thymus with therapeutic doses of radioiodine in patients with thyroid cancer. Eur. J. Nucl. Med. 20, 75–79 (1993)

    Article  CAS  PubMed  Google Scholar 

  79. F. Vermiglio et al. Iodine concentration by the thymus in thyroid carcinoma. J. Nucl. Med. 37, 1830–1831 (1996)

    CAS  PubMed  Google Scholar 

  80. J.P. Muratet, P. Giraud, Thymus accumulation of I-131 after therapeutic dose for thyroid carcinoma. Clin. Nucl. Med. 21, 736–737 (1996)

    Article  CAS  PubMed  Google Scholar 

  81. A. Serafini, G. Sfakianakis, M. Georgiou, J. Morris, Breast cyst simulating metastases on iodine-131 imaging in thyroid carcinoma. J. Nucl. Med. 39, 1910–1912 (1998)

    CAS  PubMed  Google Scholar 

  82. G. Malhotra, S.H. Moghe, R. Ranade, R.R.V. Asopa, An unusual false-positive uptake of radioiodine in pericardial effusion on posttherapy scan. Clin. Nucl. Med. 41, 568–569 (2016)

    Article  PubMed  Google Scholar 

  83. O. Geatti, B. Shapiro, P.G. Orsolon, R. Mirolo, A. Di Donna, An unusual false-positive scan in a patient with pericardial effusion. Clin. Nucl. Med. 19, 678–682 (1994)

    Article  CAS  PubMed  Google Scholar 

  84. M.M. Maslack, C.A. Wilson, Iodine-131 accumulation in a pericardial effusion. J. Nucl. Med. 28, 133 (1987)

    CAS  PubMed  Google Scholar 

  85. T.H. Tan, S.Z.A. Hassan, A rare case of isolated pericardial effusion detected by SPECT/CT on a post-therapeutic radioiodine whole-body scan. Nucl. Med. Mol. Imaging 49, 246–247 (2015)

    Article  PubMed  PubMed Central  Google Scholar 

  86. D. Peng, F. Shao, Even small pleural effusion could be potential pitfall on posttherapeutic 131I scintigraphy. Clin. Nucl. Med. 45, 925–926 (2020)

    Article  PubMed  Google Scholar 

  87. O. Bourogianni et al. Pleuropericardial cyst mimicking a metastasis of differentiated thyroid carcinoma on whole-body iodine-131 scan: a case report. Nucl. Med. Mol. Imaging 53, 361–365 (2019)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  88. C. Francese et al. Iodine 131 uptake in a pleuropericardial cyst: case report of a false-positive radioiodine total body scan result in a patient with a thyroid cancer. Eur. J. Nucl. Med. 18, 779–780 (1991)

    Article  CAS  PubMed  Google Scholar 

  89. D.T. Mason, R.L. Frye, H.N. Wagner, Radioisotope scanning of the precordial distribution of iodide in patients with myocardial infarction. Circulation 24, 1338–1341 (1961)

    Article  CAS  PubMed  Google Scholar 

  90. F. Dreyfuss, M. Ben-Porath, J. Menczel, Radioiodine uptake by the infarcted heart. Am. J. Cardiol. 6, 237–245 (1960)

    Article  CAS  PubMed  Google Scholar 

  91. D.P. Greenler, H.A. Klein, The scope of false-positive iodine-131 images for thyroid carcinoma. Clin. Nucl. Med. 14, 111–117 (1989)

    Article  CAS  PubMed  Google Scholar 

  92. A. Sinha, K.M. Bradley, J. Steatham, A. Weaver, Asymmetric breast uptake of radioiodine in a patient with thyroid malignancy: metastases or not? J. R. Soc. Med. 101, 319–320 (2008)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  93. I.R. McDougall, Whole-body scintigraphy with radioiodine-131. A comprehensive list of false-positives with some examples. Clin. Nucl. Med. 20, 869–875 (1995)

    Article  CAS  PubMed  Google Scholar 

  94. M.R. Carlisle, C. Lu, I.R. McDougall, The interpretation of 131I scans in the evaluation of thyroid cancer, with an emphasis on false positive findings. Nucl. Med. Commun. 24, 715–735 (2003)

    Article  CAS  PubMed  Google Scholar 

  95. T. Allen, P. Wiest, S. Vela, M. Hartshorne, L.A. Crooks, I-131 uptake in the breast for thyroid cancer surveillance with biopsy-proven benign tissue. Clin. Nucl. Med. 23, 585–587 (1998)

    Article  CAS  PubMed  Google Scholar 

  96. A. Ledwon, P. Soczomski, E. Paliczka-Cieslik, A. Blewaska, D. Handkiewicz-Junak, False-positive radioiodine uptake in breasts in a female haemodialysis patient. Nucl. Med. Rev. Cent. East. Eur. 24, 122–123 (2021)

    Article  PubMed  Google Scholar 

  97. L.H. Hu, S.J. Wang, R.S. Liu, Hyperprolactinemia-related 131I uptake in nonlactating breasts. Clin. Nucl. Med. 37, e57–e58 (2012)

    Article  PubMed  Google Scholar 

  98. R. Bruno et al. Sodium iodide symporter expression and radioiodine distribution in extrathyroidal tissues. J. Endocrinol. Invest. 27, 1010–1014 (2004)

    Article  CAS  PubMed  Google Scholar 

  99. H.K. Shim, M.R. Kim, Incidental findings of intense radioiodine uptake in struma ovarii and bilateral nonlactating breasts simultaneously on postablation 131I SPECT/CT for papillary thyroid cancer. Nucl. Med. Mol. Imaging 50, 353–357 (2016)

    Article  PubMed  PubMed Central  Google Scholar 

  100. M. Itani, D.H. Lewis, I-131 uptake in fat necrosis of the breast. Radiol. Case Rep. 12, 161–167 (2016)

    Article  PubMed  PubMed Central  Google Scholar 

  101. Y. Wang, L. Jiang, Y. Xu, X. Zhang, B. Liu, An unusual false-positive uptake of radioiodine caused by breast implants. Clin. Nucl. Med. 47, 646–647 (2022)

    Article  PubMed  Google Scholar 

  102. M.M. McNamara, H.P. Tsang, Hiatal hernia with reflux resulting in false positive iodine-131 scan. Clin. Nucl. Med. 23, 178–179 (1998)

    Article  CAS  PubMed  Google Scholar 

  103. M. Haghighatafshar, F. Khajehrahimi, Hiatal hernia uptake of iodine-131 mimicking mediastinal metastasis of papillary thyroid carcinoma. Indian J. Nucl. Med. 30, 347–349 (2015)

    Article  PubMed  PubMed Central  Google Scholar 

  104. L.L. Willis, R.J. Cowan, Mediastinal uptake of I-131 in a hiatal hernia mimicking recurrence of papillary thyroid carcinoma. Clin. Nucl. Med. 18, 961–963 (1993)

    Article  CAS  PubMed  Google Scholar 

  105. M. Freeman, P. Roach, B. Robinson, M. Shields, Hiatal hernia in iodine-131 scintigraphy: a potential cause of false-positive midline thoracic uptake. Clin. Nucl. Med. 28, 709–710 (2003)

    Article  PubMed  Google Scholar 

  106. J.A. Schneider et al. Hiatal hernia on whole-body radioiodine survey mimicking metastatic thyroid cancer. Clin. Nucl. Med. 18, 751–753 (1993)

    Article  CAS  PubMed  Google Scholar 

  107. Y. Ho, R. Hicks, Hiatus hernia: a potential cause of false-positive iodine-131 scan in thyroid carcinoma. Clin. Nucl. Med. 23, 621–622 (1998)

    Article  CAS  PubMed  Google Scholar 

  108. F.J. García-Gómez et al. Intrathoracic stomach mimicking bone metastasis from thyroid cancer in whole-body iodine-131 scan diagnosed by SPECT/CT.Arch Endocrinol. Metab. 61, 288–290 (2017)

    Article  PubMed  PubMed Central  Google Scholar 

  109. N. Nair, S. Basu, H. Parkhale, Unusual uptake of radioiodine in the chest in a patient with thyroid carcinoma. Br. J. Radiol. 77, 63–67 (2004)

    Article  CAS  PubMed  Google Scholar 

  110. A. Ozdemir et al. Abnormal iodine-131 uptake in the mediastinum caused by achalasia. Clin. Nucl. Med. 23, 706–707 (1998)

    Article  CAS  PubMed  Google Scholar 

  111. H. Boulahdour, M. Meignan, D. Melliere, F. Braga, P. Galle, False-positive I-131 scan induced by Zenker’s diverticulum. Clin. Nucl. Med. 17, 243–244 (1992)

    Article  CAS  PubMed  Google Scholar 

  112. K. Rashid, W. Johns, K. Chasse, M. Walker, S.M. Gupta, Esophageal diverticulum presenting as metastatic thyroid mass on iodine-131 scintigraphy. Clin. Nucl. Med. 31, 405–408 (2006)

    Article  PubMed  Google Scholar 

  113. L.M.M. Bares et al. I-131 visualization of thoracic aortic aneurysm after radioiodine administration for thyroid carcinoma. Clin. Nucl. Med. 33, 553–554 (2008)

    Article  Google Scholar 

  114. R.H. Caplan, G.A. Gundersen, R.M. Abellera, W.A. Kisken, Uptake of iodine-131 by a Meckel’s diverticulum mimicking metastatic thyroid cancer. Clin. Nucl. Med. 12, 760–762 (1987)

    Article  CAS  PubMed  Google Scholar 

  115. D.I. Glazer et al. SPECT/CT evaluation of unusual physiologic radioiodine biodistributions: pearls and pitfalls in image interpretation. Radiographics. 33, 397–418 (2013)

    Article  PubMed  Google Scholar 

  116. R.J. Zucker, Y.C. Bradley, M.O. Toney, R.S. Bridwell, Gastric volvulus detected with iodine-131 whole-body imaging. Clin. Nucl. Med. 25, 303–305 (2000)

    Article  CAS  PubMed  Google Scholar 

  117. Z.C. Hannoush, J.D. Palacios, R.A. Kuker, S. Casula, False positive findings on I-131 WBS and SPECT/CT in patients with history of thyroid cancer: case series. Case Rep. Endocrinol. 2017, 8568347 (2017)

    PubMed  PubMed Central  Google Scholar 

  118. F.J. Pena Pardo et al. Solitary focus in the liver in a thyroid cancer patient after a whole body scan with 131 iodine. Rev. Esp. Med. Nucl. 26, 294–296 (2007)

    Article  CAS  PubMed  Google Scholar 

  119. Ö. Ömür et al. False-positive I-131 accumulation in a hepatic hydatid cyst. Clin. Nucl. Med. 32, 930–932 (2007)

    Article  PubMed  Google Scholar 

  120. D.L. You, K.Y. Tzen, J.F. Chen, P.F. Kao, M.F. Tsai, False-positive whole-body iodine-131 scan due to intrahepatic duct dilatation. J. Nucl. Med. 38, 1977–1979 (1997)

    CAS  PubMed  Google Scholar 

  121. V. Mohan, R.C. Jones, A.J. Drake, P.L. Daly, K.M.M. Shakir, Littoral cell angioma presenting as metastatic thyroid carcinoma to the spleen. Thyroid 15, 170–175 (2005)

    Article  PubMed  Google Scholar 

  122. D.M. Achong, E. Oates, S.L. Lee, F.J. Doherty, Gallbladder visualization during post-therapy iodine-131 imaging of thyroid carcinoma. J. Nucl. Med. 32, 2275–2277 (1991)

    CAS  PubMed  Google Scholar 

  123. F.J. Welte, R.H. Dann, J.P. Polga, L.E. Gianturco, Gallbladder visualization on I-131 post-ablative whole body imaging mimicking hepatic metastases. Radiol. Case Rep. 3, 180 (2015)

    Article  PubMed  PubMed Central  Google Scholar 

  124. K. Ünal, Ö.Ü. Akdemir, Unexpected uptake by the gallbladder in post-ablative I-131 scan. Mol. Imaging Radionucl. Ther. 24, 85–86 (2015)

    Article  PubMed  PubMed Central  Google Scholar 

  125. F. Brucker-Davis et al. False-positive iodine-131 whole-body scans due to cholecystitis and sebaceous cyst. J. Nucl. Med. 37, 1690–1693 (1996)

    CAS  PubMed  Google Scholar 

  126. H.T. Turoglu, S. Naddaf, I. Young, H.M. Abdel-Dayem, Infected sebaceous cyst. A cause for false-positive total-body I-123 metastatic survey for thyroid cancer. Clin. Nucl. Med. 21, 887 (1996)

    Article  CAS  PubMed  Google Scholar 

  127. C. Okuyama et al. False-positive I-131 accumulation in a liver cyst in a patient with thyroid carcinoma. Clin. Nucl. Med. 26, 198–201 (2001)

    Article  CAS  PubMed  Google Scholar 

  128. D.H. Gunawardana, A.G. Pitman, M. Lichtenstein, Benign hepatic cyst mimicking a functional thyroid carcinoma metastasis on whole-body I-131 imaging. Clin. Nucl. Med. 28, 527–528 (2003)

    Article  PubMed  Google Scholar 

  129. A. Maciejewski, R. Czepczynski, M. Ruchala, False-positive radioiodine whole-body scan due to a renal cyst. Endokrynol. Pol. 69, 736–739 (2018)

    Article  PubMed  Google Scholar 

  130. O. Kraft, P. Širůček, L. Mrhač, M. Havel, I-131 false positive uptake in a huge parapelvic renal cyst. Nucl. Med. Rev. Cent. East. Eur. 14, 36–37 (2011)

    Article  PubMed  Google Scholar 

  131. M.B. Brachman et al. False-positive iodine-131 body scan caused by a large renal cyst. Clin. Nucl. Med. 13, 416–418 (1988)

    Article  CAS  PubMed  Google Scholar 

  132. C. Castillo-Berrio et al. Accumulation of (131)INa activity in renal cysts unrelated to metastatic disease in a patient with differentiated thyroid cancer. Rev. Esp. Med. Nucl. Imagen Mol. 35, 70–71 (2016)

    CAS  PubMed  Google Scholar 

  133. A. Campennì et al. Radioiodine uptake in a renal cyst mimicking a metastasis in a patient affected by differentiated thyroid cancer: case report and review of the literature. Ann. Nucl. Med. 28, 472–476 (2014)

    Article  PubMed  Google Scholar 

  134. C. Wen, E. Iuanow, E. Oates, S.L. Lee, R. Perrone, Post-therapy iodine-131 localization in unsuspected large renal cyst: possible mechanisms. J. Nucl. Med. 39, 2158–2161 (1998)

    CAS  PubMed  Google Scholar 

  135. J.-R. Oh, B.-C. Ahn, False-positive uptake on radioiodine whole-body scintigraphy: physiologic and pathologic variants unrelated to thyroid cancer. Am. J. Nucl. Med. Mol. Imaging 2, 362–385 (2012)

    PubMed  PubMed Central  Google Scholar 

  136. B. Letaief, S. Boughattas, M. Guezguez, H. Hassine, H. Essabbah, Abdominal uptake of I-131 revealing a renal cyst. Clin. Nucl. Med. 26, 255–256 (2001)

    Article  CAS  PubMed  Google Scholar 

  137. J. Lee, H.S. Song, J.H. Choi, J. Lee, Iodine uptake in retroperitoneal cysts after radioactive iodine treatment. Indian J. Nucl. Med. 35, 76–77 (2020)

    Article  PubMed  Google Scholar 

  138. L. Kalhor, Autosomal dominant polycystic kidney disease: a potential mistake in the interpretation of radioiodine whole-body scintigraphy. Radiol. Case Rep. 13, 453–455 (2018)

    Article  PubMed  PubMed Central  Google Scholar 

  139. Y.X. Mi, X. Sui, J.M. Huang, L.G. Wei, P. Xie, Incidentally polycystic kidney disease identified by SPECT/CT with post-therapy radioiodine scintigraphy in a patient with differentiated thyroid carcinoma: a case report. Medicine (Baltimore) 96, e8348 (2017)

    Article  PubMed  Google Scholar 

  140. G. Shen, Z. Qi, R. Huang, B. Liu, A. Kuang, False-positive uptake of radioiodine in renal hamartoma in a patient with differentiated thyroid cancer. Clin. Nucl. Med. 42, 709–710 (2017)

    Article  PubMed  Google Scholar 

  141. M. Haghighatafshar, F. Shekoohi-Shooli, Adrenocortical adenoma manifesting as false-positive iodine accumulation in a patient with history of thyroid carcinoma. Radiol. Case Rep. 13, 949–951 (2018)

    Article  PubMed  PubMed Central  Google Scholar 

  142. T. Murokawa et al. Exophytic pancreatic lymphoepithelial cyst incidentally detected in a differentiated thyroid cancer patient on whole-body I-131 scan: a case report. Surg. Case Rep. 8, 34 (2022)

    Article  PubMed  PubMed Central  Google Scholar 

  143. P.W. Wang, H.Y. Chen, C.H. Li, W.J. Chen, Uptake of I-131 by an abdominal neurilemoma mimicking metastatic thyroid carcinoma. Clin. Nucl. Med. 18, 964–966 (1993)

    Article  CAS  PubMed  Google Scholar 

  144. M. Meyer, Y. Godbert, I. Soubeyran, A.L. Cazeau, F. Bonichon, Benign cystic mesothelioma: false-positive iodine accumulation in a patient with oncocytic follicular thyroid carcinoma. Clin. Nucl. Med. 39, e395–e397 (2014)

    Article  PubMed  Google Scholar 

  145. B. De Keizer et al. I-131 accumulation in a benign cystic mesothelioma in a patient with follicular thyroid cancer. Thyroid 18, 369–371 (2008)

    Article  PubMed  Google Scholar 

  146. Y. Anongpornjossakul et al. Incidental gallbladder cancer visualized from posttreatment 131I whole-body scan. Clin. Nucl. Med. 41, e162–e163 (2016)

    Article  PubMed  Google Scholar 

  147. S.Y. Wu et al. I-131 total-body scan: localization of disseminated gastric adenocarcinoma. Case report and survey of the literature. J. Nucl. Med. 25, 1204–1208 (1984)

    CAS  PubMed  Google Scholar 

  148. F. Rosar et al. Strongly radioiodine-positive pancreatic adenocarcinoma mimicking metastasis of differentiated thyroid cancer. Diagnostics 12, 1934 (2022)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  149. E. Acar, A. Akgun, K. Kocacelebi, K. Kumanlioglu, M. Tuncyurek, I-131 uptake in malignant fibrous histiocytoma. Clin. Nucl. Med. 32, 580–581 (2007)

    Article  PubMed  Google Scholar 

  150. N. Hod, S. Lantsberg, D. Levin, Radioiodine uptake in incidentally detected neuroendocrine tumor: correlative imaging with FDG PET/CT and 68 Ga-DOTATATE PET/CT. Clin. Nucl. Med. 47, E643–E646 (2022)

    Article  PubMed  Google Scholar 

  151. O. Konez, L.G. Hanelin, E.L. Jenison, M. Goyal, W. Randolph, Functioning liver metastases on an I-131 whole-body scan: a case of malignant struma ovarii. Clin. Nucl. Med. 25, 465–496 (2000)

    Article  CAS  PubMed  Google Scholar 

  152. S.C. Cherng et al. Malignant struma ovarii with peritoneal implants and pelvic structures and liver metastases demonstrated by I-131 SPECT and low-dose CT. Clin. Nucl. Med. 30, 797–798 (2005)

    Article  ADS  PubMed  Google Scholar 

  153. C. Sioka, N. Dimakopoulos, G. Kouraklis, I. Kotsalou, A. Zouboulidis, False-positive whole-body scan after I-131 therapy in a patient with intestinal scar. Clin. Nucl. Med. 31, 232–233 (2006)

    Article  PubMed  Google Scholar 

  154. S. Rudoni et al. [Dermoid cyst of the ovary. False positive diagnosis in iodine 131 scintigraphy of differentiated thyroid cancers]. Presse Med. 27, 1379–1381 (1998)

    CAS  PubMed  Google Scholar 

  155. M. Lakshmanan et al. Pelvic radioiodine uptake in a rectal wall teratoma after thyroidectomy for papillary carcinoma. J. Nucl. Med. 33, 1848–1850 (1992)

    MathSciNet  CAS  PubMed  Google Scholar 

  156. H.M. Kosari et al. Incidental finding of a dermoid cyst in a whole-body iodine scan: importance of using [131I]SPECT/CT in the differentiated thyroid carcinoma. Nucl. Med. Rev. Cent. East. Eur. 24, 106–107 (2021)

    Article  Google Scholar 

  157. S. Yoon, I. Soo Hong, Ovarian teratoma mimicking metastasis on I-131 scan: a case report. Nucl. Med. Mol. Imaging 47, 52–54 (2013)

    Article  PubMed  Google Scholar 

  158. A. Campennì et al. Abnormal radioiodine uptake on post-therapy whole body scan and sodium/iodine symporter expression in a dermoid cyst of the ovary: report of a case and review of the literature. Arch. Endocrinol. Metab. 59, 351–354 (2015)

    Article  PubMed  Google Scholar 

  159. C. Nascimento et al. Persistent disease and recurrence in differentiated thyroid cancer patients with undetectable postoperative stimulated thyroglobulin level. Endocr. Relat. Cancer 18, R29–R40 (2011)

    CAS  PubMed  Google Scholar 

  160. J.P.H. Van Wijk, H.S. Broekhuizen-de Gast, A.J.J. Smits, M.E.I. Schipper, P.M.J. Zelissen, Scintigraphic detection of benign ovarian teratoma after total thyroidectomy and radioactive iodine for differentiated thyroid cancer. J. Clin. Endocrinol. Metab. 97, 1094–1095 (2012)

    Article  PubMed  Google Scholar 

  161. T. Wu, X. Zhao, H. Xu, False-positive radioiodine uptake in simple ovarian cyst in a DTC patient: a case report. Front. Oncol. 11, 665135 (2021)

    Article  PubMed  PubMed Central  Google Scholar 

  162. F.A. Almohamad et al. False-positive radioiodine accumulation in a huge pelvic mass after thyroidectomy for papillary carcinoma, a case report from Syria. J. Surg. Case Rep. 2018, rjy028 (2018)

    Article  PubMed  PubMed Central  Google Scholar 

  163. H.Y. Jang et al. False-positive radioiodine uptake in a functional ovarian cyst in a patient treated with total thyroidectomy for papillary cancer. Intern. Med. 52, 2321–2323 (2013)

    Article  PubMed  Google Scholar 

  164. M. Lungo et al. [Ovarian endometriosis cyst with iodine 131 uptake: first case of false positive in the follow up for differentiated thyroid carcinoma]. Ann Endocrinol 61, 147–150 (2000)

    CAS  Google Scholar 

  165. D. Çayır, M. Araz, M. Apaydın, E. Çakal, Inguinal endometriosis visualized on I-131 whole body scan. Mol. Imaging Radionucl. Ther. 27, 52–54 (2018)

    Article  PubMed  PubMed Central  Google Scholar 

  166. J. Flug et al. False-positive I-131 uptake by an ovarian serous cystadenofibroma. Clin. Nucl. Med. 37, 178–180 (2012)

    Article  PubMed  Google Scholar 

  167. O. Turker, I. Dogan, K. Kumanlioglu, Radioiodine accumulation in a large adnexal cystadenofibroma. Thyroid 20, 561–562 (2010)

    Article  CAS  PubMed  Google Scholar 

  168. M. Mebarki et al. Radioiodine accumulation in a giant ovarian cystadenofibroma detected incidentally by 131-I whole body scans. Case Rep. Radiol. 2012, 1–3 (2012)

    Article  Google Scholar 

  169. E.E. Kim, G. Pjura, A. Gobuty, R. Verani, 131I uptake in a benign serous cystadenoma of the ovary. Eur. J. Nucl. Med. 9, 433–435 (1984)

    Article  CAS  PubMed  Google Scholar 

  170. H.J. Song, Y.L. Xue, Y.H. Xu, Z.L. Qiu, Q.Y. Luo, Abnormal 131I uptake in a benign serous ovarian cystadenoma mimicking bladder physiological uptake. Clin. Nucl. Med. 37, e59–e60 (2012)

    Article  PubMed  Google Scholar 

  171. T.L. Haaga, D.C. Yoo, R. Ortiz, R.B. Noto, Benign ovarian serous cystadenoma mimicking papillary thyroid carcinoma metastasis on I-131 SPECT/CT. Med. Health. R. I. 95, 57–59 (2012)

    PubMed  Google Scholar 

  172. Z.L. Qiu, Y.H. Xu, H.J. Song, Q.Y. Luo, Unusual 131I uptake in a benign mucinous cystadenoma of the ovary in a patient with papillary thyroid cancer. Clin. Nucl. Med. 35, 965–966 (2010)

    Article  PubMed  Google Scholar 

  173. O. Morel et al. Abnormal iodine-131 uptake in a benign mucinous ovarian cystadenoma mimicking struma ovarii. Clin. Nucl. Med. 32, 64–66 (2007)

    Article  PubMed  Google Scholar 

  174. A.A. Jammah, A. Driedger, I. Rachinsky, Incidental finding of ovarian teratoma on post-therapy scan for papillary thyroid cancer and impact of SPECT/CT imaging. Arq. Bras. Endocrinol. Metabol. 55, 490–493 (2011)

    Article  PubMed  Google Scholar 

  175. M. Salvatori et al. Riscontro occasionale di “struma ovarii” in paziente con carcinoma tiroideo. Radiol. Medica 81, 744–747 (1991)

    CAS  Google Scholar 

  176. M. Gauthé, A. Kelly, C. Dejax, F. Cachin, N. Bourdel, Incidental scintigraphic finding of ovarian teratoma containing normal thyroid tissue on post-radioactive iodine therapy for papillary thyroid cancer. Clin. Nucl. Med. 38, 467–468 (2013)

    Article  PubMed  Google Scholar 

  177. C.P. Wagner, B.N. Hicks, K.M. Nakamura, Incidental scintigraphic detection of struma ovarii following total thyroidectomy for papillary thyroid cancer. Radiol. Case Rep. 6, 478 (2015)

    Article  PubMed  PubMed Central  Google Scholar 

  178. S.T. Zwas, Z. Heyman, L.M. Lieberman, 131I ovarian uptake in a whole-body scan for thyroid carcinoma. Semin. Nucl. Med. 19, 340–342 (1989)

    Article  CAS  PubMed  Google Scholar 

  179. W. Macdonald, J. Armstrong, Benign struma ovarii in a patient with invasive papillary thyroid cancer: detection with I-131 SPECT-CT. Clin. Nucl. Med. 32, 380–382 (2007)

    Article  PubMed  Google Scholar 

  180. C. Ghander, D. Lussato, B. Conte Devolx, O. Mundler, D. Taïeb, Incidental diagnosis of struma ovarii after thyroidectomy for thyroid cancer: functional imaging studies and follow-up. Gynecol. Oncol. 102, 378–380 (2006)

    Article  CAS  PubMed  Google Scholar 

  181. S.T. Lim, H.J. Jeong, M.J. Chung, C.Y. Yim, M.H. Sohn, Malignant struma ovarii demonstrated on post-therapy radioiodine scan after total thyroidectomy for papillary thyroid cancer. Clin. Nucl. Med. 33, 429–431 (2008)

    Article  PubMed  Google Scholar 

  182. O. Kraft et al. I-131 uptake in an ovarian tumor: differential diagnosis for abdominal I-131 uptake. Clin. Nucl. Med. 34, 390–392 (2009)

    Article  PubMed  Google Scholar 

  183. A. Sellem, I. Msakni, W. Elajmi, H. Hammami, Pitfall of I-131 whole body scan: a mucinous adenocarcinoma of the ovary. Pan Afr. Med. J. 36, 1–6 (2020)

    Article  Google Scholar 

  184. M. Mattern, E. Staab, I-131 localization in hematocolpos: a differential diagnosis consideration for pelvic I-131 uptake. Clin. Nucl. Med. 32, 659–660 (2007)

    Article  PubMed  Google Scholar 

  185. I. Rachinsky, A. Driedger, Iodine-131 uptake in a menstruating uterus: value of SPECT/CT in distinguishing benign and metastatic iodine-positive lesions. Thyroid 17, 901–902 (2007)

    Article  PubMed  Google Scholar 

  186. L. Liu, Y. Chen, T. Tian, R. Huang, B. Liu, Physiologic uterine uptake of radioiodine during menstruation demonstrated by SPECT/CT. Clin. Nucl. Med. 44, 975–977 (2019)

    Article  PubMed  Google Scholar 

  187. Y. Nishiyama et al. False-positive iodine-131 whole-body imaging due to gestational sac. Clin. Nucl. Med. 23, 535–536 (1998)

    Article  CAS  PubMed  Google Scholar 

  188. K. Hirata et al. Radioiodine therapy for thyroid cancer depicted uterine leiomyoma. Clin. Nucl. Med. 34, 180–181 (2009)

    Article  PubMed  Google Scholar 

  189. T. Isoda et al. Nabothian cyst a predominant cause of false-positive iodine uptake in uterus: comparison of SPECT/CT and pelvic MRI. Clin. Nucl. Med. 39, 680–684 (2014)

    Article  PubMed  Google Scholar 

  190. S. Liu et al. Nabothian cyst associated with high false-positive incidence of iodine-131 uptake in whole-body scans after treatment for differentiated thyroid cancer. Nucl. Med. Commun. 34, 1204–1207 (2013)

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  191. F.J. García-Gómez, T. Cambil-Molina, J. Jiménez Gallardo, T. Martín-Hernández, J. Castro-Montaño, False-positive 131I uptake secondary to nabothian cyst. Rev. Esp. Med. Nucl. Imagen Mol. 38, 114–115 (2019)

    PubMed  Google Scholar 

  192. J. Tong, Y. Jin, M. Liu, Z. Lv, L. Chen, False-positive uptake of 131I due to tubal ligation in a patient with papillary thyroid cancer. Clin. Nucl. Med. 43, 375–376 (2018)

    Article  PubMed  Google Scholar 

  193. S.S. Gültekin, A. Dilli, A.T. Arikök, H. Bostanci, A.O. Hasdemir, The false-positive radioiodine I-131 uptake in the foreign body granuloma located in gluteal adipose tissue. Radiol. Oncol. 46, 28–31 (2012)

    Article  PubMed  Google Scholar 

  194. S. Kinuya, K. Yokoyama, T. Michigishi, N. Tonami, I-131 accumulation in folliculitis of the scalp. Clin. Nucl. Med. 21, 807–808 (1996)

    Article  CAS  PubMed  Google Scholar 

  195. C. Regalbuto et al. False-positive findings on 131I whole-body scans because of posttraumatic superficial scabs. J. Nucl. Med. 43, 207–209 (2002)

    PubMed  Google Scholar 

  196. A.W. Chowdhary et al. Posttraumatic scab on 131I whole-body scan-a false-positive finding. Clin. Nucl. Med. 46, 512–514 (2021)

    Article  PubMed  Google Scholar 

  197. J. Andreas, K. Bruhl, D. Eissner, False-positive I-131 whole-body imaging after I-131 therapy for a follicular carcinoma. Clin. Nucl. Med. 22, 123–124 (1997)

    Article  CAS  PubMed  Google Scholar 

  198. L. Xiao, L. Jiang, R. Huang, R. Tian, B. Liu, An unusual false-positive uptake of radioiodine caused by posttraumatic superficial scab. Clin. Nucl. Med. 47, 350–351 (2022)

    Article  PubMed  Google Scholar 

  199. N. Agrawal et al. Integrated genomic characterization of papillary thyroid carcinoma. Cell 159, 676–690 (2015)

    Article  Google Scholar 

  200. G.G. Bural, R.L. Peel, J.M. Mountz, Benign epithelial cyst mimicking thyroid cancer metastasis: a false-positive finding on post-therapy I-131 scan. Clin. Nucl. Med. 37, 88–90 (2012)

    Article  PubMed  Google Scholar 

  201. M. Oporto et al. Fibroelastic pseudotumor elastofibroma dorsi detected by 18F-FDG PET/CT scan and by postherapy radioiodine SPECT/CT. Rev. Esp. Med. Nucl. Imagen Mol. 37, 46–49 (2018)

    CAS  PubMed  Google Scholar 

  202. L. Liu, Y. Chen, T. Tian, R. Huang, B. Liu, An unusual false-positive uptake of radioiodine caused by metallic implants. Clin. Nucl. Med. 44, E495–E496 (2019)

    Article  PubMed  Google Scholar 

  203. S. Modoni, G. Martino, M. Guerra, V. Frusciante, Unusual radioiodine uptake caused by metallic sutures in the skull in a patient with thyroid cancer. Clin. Nucl. Med. 25, 1053–1054 (2000)

    Article  CAS  PubMed  Google Scholar 

  204. J.P. Walsh, J.B. Sims, P. Iranpour, False-positive radioiodine uptake from an intracranial surgical clip. Clin. Nucl. Med. 47, e279–e280 (2022)

    Article  PubMed  Google Scholar 

  205. R. Laguna, F. Silva, J. Vazquez-Sellés, E. Orduña, C. Flores, Vertebral hemangioma mimicking a metastatic bone lesion in well-differentiated thyroid carcinoma. Clin. Nucl. Med. 25, 611–613 (2000)

    Article  CAS  PubMed  Google Scholar 

  206. B. Yazici, A. Oral, C. Eraslan, M. Argin, Ö. Ömür, False-positive 131I uptake in a benign bone lesion on post-therapy scan. Clin. Nucl. Med. 41, e63–e65 (2016)

    Article  PubMed  Google Scholar 

  207. S. Muherji, H.A. Ziessman, J.M. Earll, J.W. Keyes, False-positive iodine-131 whole body scan due to pectus excavatum. Clin. Nucl. Med. 13, 207–208 (1988)

    Article  CAS  PubMed  Google Scholar 

  208. S. Ajmi et al. Tc-99m and I-131 uptake in widespread bone metastases from undetectable digestive adenocarcinoma. Clin. Nucl. Med. 36, 1020–1022 (2011)

    Article  PubMed  Google Scholar 

  209. C. Durante et al. Long-term outcome of 444 patients with distant metastases from papillary and follicular thyroid carcinoma: benefits and limits of radioiodine therapy. J. Clin. Endocrinol. Metab. 91, 2892–2899 (2006)

    Article  CAS  PubMed  Google Scholar 

  210. M. Schlumberger, S. Leboulleux, Current practice in patients with differentiated thyroid cancer. Nat. Rev. Endocrinol. 17, 176–188 (2021)

    Article  CAS  PubMed  Google Scholar 

  211. G. Noussios, P. Anagnostis, D.G. Goulis, D. Lappas, K. Natsis, Ectopic thyroid tissue: anatomical, clinical, and surgical implications of a rare entity. Eur. J. Endocrinol. 165, 375–382 (2011)

    Article  CAS  PubMed  Google Scholar 

  212. M. Jin et al. Clinical implication of World Health Organization classification in patients with follicular thyroid carcinoma in South Korea: a multicenter cohort study. Endocrinol. Metab. 35, 618–627 (2020)

    Article  Google Scholar 

  213. J.J. Sancho, T.W.J. Lennard, I. Paunovic, F. Triponez, A. Sitges-Serra, Prophylactic central neck disection in papillary thyroid cancer: a consensus report of the European Society of Endocrine Surgeons (ESES). Langenbeck’s Arch. Surg 399, 155–163 (2014)

    Article  Google Scholar 

  214. S.-R. Wang et al. Diagnostic value of multiple diagnostic methods for lymph node metastases of papillary thyroid carcinoma: a systematic review and meta-analysis. Front. Oncol. 12, 990603 (2022)

    Article  PubMed  PubMed Central  Google Scholar 

  215. M. Zhong et al. Impact of lung metastasis versus metastasis of bone, brain, or liver on overall survival and thyroid cancer-specific survival of thyroid cancer patients: a population-based study. Cancers 14, 3133 (2022)

    Article  PubMed  PubMed Central  Google Scholar 

  216. S. Sathiyamoorthy, Z. Maleki, Cytomorphologic overlap of differentiated thyroid carcinoma and lung adenocarcinoma and diagnostic value of TTF-1 and TGB on cytologic material. Diagn. Cytopathol. 42, 5–10 (2014)

    Article  PubMed  Google Scholar 

  217. J. Davidson, I.R. McDougall, How frequently is the thymus seen on whole-body iodine-131 diagnostic and post-treatment scans? Eur. J. Nucl. Med. 27, 425–430 (2000)

    Article  CAS  PubMed  Google Scholar 

  218. S. Jun et al. Prediction of treatment response to 131I therapy by diffuse hepatic uptake intensity on post-therapy whole-body scan in patients with distant metastases of differentiated thyroid cancer. Ann. Nucl. Med. 29, 603–612 (2015)

    Article  CAS  PubMed  Google Scholar 

  219. J.W. Lee, S.M. Lee, J. Choi, Clinical significance of diffuse hepatic uptake on post-therapeutic early and delayed (131)I scan in differentiated thyroid cancer: a preliminary report. Ann. Nucl. Med. 29, 190–197 (2015)

    Article  PubMed  Google Scholar 

  220. Ö. Ömür, A. Akgün, Z. Özcan, Ç. Şen, H. Özklç, Clinical implications of diffuse hepatic uptake observed in postablative and post-therapeutic I-131 scans. Clin. Nucl. Med. 34, 11–14 (2009)

    Article  PubMed  Google Scholar 

  221. A. Madani, Y. Jozaghi, R. Tabah, J. How, E. Mitmaker, Rare metastases of well-differentiated thyroid cancers: a systematic review. Ann. Surg. Oncol. 22, 460–466 (2015)

    Article  PubMed  Google Scholar 

  222. B. M, Hepatic visualization after 131 I in patients with thyroid carcinoma (Cont.). N. Engl. J. Med. 296, 634–634 (1977)

    Article  Google Scholar 

  223. S. Donato, H. Simoes, V. Leite, Malignant Struma Ovarii with Concurrent Thyroid Cancer: outcomes during and after pregnancy. Eur. Thyroid J. 10, 523–527 (2021)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  224. H. Fragnaud et al. Mid and long-term overall survival after carcinologic resections of thyroid cancer bone metastases. Front. Surg. 9, 965951 (2022)

    Article  PubMed  PubMed Central  Google Scholar 

  225. R. Zhang et al. Bone metastases in newly diagnosed patients with thyroid cancer: a large population-based cohort study. Front. Oncol. 12, 955629 (2022)

    Article  MathSciNet  PubMed  PubMed Central  Google Scholar 

  226. G. Mazziotti et al. Real-life management and outcome of thyroid carcinoma-related bone metastases: results from a nationwide multicenter experience. Endocrine 59, 90–101 (2018)

    Article  CAS  PubMed  Google Scholar 

  227. A. Farooki, V. Leung, H. Tala, R.M. Tuttle, Skeletal-related events due to bone metastases from differentiated thyroid cancer. J. Clin. Endocrinol. Metab. 97, 2433–2439 (2012)

    Article  CAS  PubMed  Google Scholar 

  228. M. Schmidt, M. Dietlein, U. Schröder, H. Schicha, False-positive uptake of I-131 in a laryngocele mimicking thyroid remnant after thyroidectomy for papillary thyroid carcinoma. Clin. Nucl. Med. 31, 716–717 (2006)

    Article  PubMed  Google Scholar 

  229. M. Mulazimoglu, S. Koca, M.O. Tamam, E. Uyanik, T. Ozpacaci, False-positive findings in post-treatment iodine-131 whole-body scintigraphy in a nasolacrimal sac cyst, confirmed with SPECT/CT and MRI. Clin. Nucl. Med. 36, 805–807 (2011)

    Article  PubMed  Google Scholar 

  230. N.L. Lebo, F. Raymond, M.J. Odell, Selectively false-positive radionuclide scan in a patient with sarcoidosis and papillary thyroid cancer: a case report and review of the literature. J. Otolaryngol. Head Neck Surg. 44, 18 (2015)

    Article  PubMed  PubMed Central  Google Scholar 

  231. F. Yang, L. Cao, C. Zhang, An unusual false-positive uptake of radioiodine caused by pulmonary vasculature: the usefulness of SPECT/CT. Hell. J. Nucl. Med. 23, 204–205 (2020)

    PubMed  Google Scholar 

  232. S.H. Park, M. Seo, T.Y. Park, S. Nam-Goong, An intrapericardial ectopic thyroid mimicking metastasis in a patient with papillary thyroid cancer: Localization, differential diagnosis by 18F-FDG PET/CT and ablation by 131I. Hell. J. Nucl. Med. 19, 272–274 (2016)

    PubMed  Google Scholar 

  233. D. Kayano, T. Michigishi, K. Ichiyanagi, A. Inaki, S. Kinuya, I-131 uptake in a thymic cyst. Clin. Nucl. Med. 35, 438–439 (2010)

    Article  PubMed  Google Scholar 

  234. E. Yano et al. I-131 false-positive uptake in a thymic cyst with expression of the sodium-iodide symporter: a case report. Medicine (Baltimore) 101, E29282 (2022)

    Article  PubMed  Google Scholar 

  235. A.K. Singh, A.A. Bodolan, M.P. Gilbert, A false positive I-131 metastatic survey caused by radioactive iodine uptake by a benign thymic cyst. Case Rep. Endocrinol. 2017, 1–4 (2017)

    Article  Google Scholar 

  236. B.D. Nguyen, M.C. Roarke, Epiphrenic diverticulum: potential pitfall in thyroid cancer iodine-131 scintigraphy. Clin. Nucl. Med. 30, 631–632 (2005)

    Article  PubMed  Google Scholar 

  237. H.C. Song, S.M. Kim, Y.J. Heo, H.S. Bom, Retention of iodine-131 in a thoracic esophageal diverticulum mimicking metastatic thyroid cancer. Clin. Nucl. Med. 27, 896–897 (2002)

    Article  PubMed  Google Scholar 

  238. R. Wang, K. Zhou, Q. Fan, H. Chen, C. Fan, A false-positive I-131 finding of duodenum diverticulum in thyroid cancer evaluation by SPECT/CT: A case report. Medicine 97, e9997 (2018)

    Article  PubMed  PubMed Central  Google Scholar 

  239. M. Attard et al. False-positive results of an iodine-131 whole-body scan caused by an ectopic kidney. Clin. Nucl. Med. 26, 271–273 (2001)

    Article  CAS  PubMed  Google Scholar 

  240. L. Husmann et al. Pyelocaliceal diverticulum as a rare pitfall in I-131 post-therapy scanning. Clin. Nucl. Med. 35, 443–444 (2010)

    Article  PubMed  Google Scholar 

  241. S.S. Demir, G.E. Aktaş, A. Polat, A. Sarıkaya, Ectopic pelvic kidney mimicking sacral metastasis on post-therapy iodine-131 scan of a thyroid cancer patient. Mol. Imaging Radionucl. Ther. 26, 43–46 (2017)

    Article  Google Scholar 

  242. E. Varoglu, M. Yildirim, R. Bayrakdar, A.M. Kantarci, H. Uslu, Radioiodine pooling in dilated greater saphenous vein mimicking contamination. Clin. Nucl. Med. 28, 866–868 (2003)

    Article  PubMed  Google Scholar 

  243. L. Luo, J. Wang, J. Xia, R. Zhang, X. Yao, False-positive uptake of 131I from basal cell papilloma in a patient with metastatic papillary thyroid cancer. Clin. Nucl. Med. 46, 358–360 (2021)

    Article  PubMed  Google Scholar 

  244. T. Winkens, S. Nietzsche, M. Gottschaldt, M. Freesmeyer, Nonspecific iodine accumulation in surgical suture material mimicking follicular thyroid cancer bone metastasis in (131)I scintigraphy. Clin. Nucl. Med. 39, 209–210 (2014)

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Division of Endocrinology and Diabetes Prevention and Care, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy

    Cristina Basso, Alessandra Colapinto, Valentina Vicennati, Alessandra Gambineri, Carla Pelusi, Guido Di Dalmazi, Uberto Pagotto & Andrea Repaci

  2. Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum University of Bologna, Bologna, Italy

    Cristina Basso, Alessandra Colapinto, Valentina Vicennati, Alessandra Gambineri, Carla Pelusi, Guido Di Dalmazi & Uberto Pagotto

  3. Radiation Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy

    Elisa Lodi Rizzini

  4. Nuclear Medicine, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy

    Elena Tabacchi, Arber Golemi, Letizia Calderoni & Stefano Fanti

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U.P.: Writing—Review & Editing, Supervision. A.R.: Conceptualization, Methodology, Writing—Review & Editing. G.D.D.: Validation, Writing—Review & Editing. A.C.: Writing—Review & Editing. C.B.: Conceptualization, Methodology, Data curation, Writing—Original draft preparation. All authors reviewed the manuscript, have accepted responsibility for the entire content of this manuscript, and approved its submission.

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Basso, C., Colapinto, A., Vicennati, V. et al. Radioiodine whole body scan pitfalls in differentiated thyroid cancer. Endocrine (2024). https://doi.org/10.1007/s12020-024-03754-y

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