Abstract
Purpose
The study evaluated high-intensity-focused ultrasound (HIFU) for benign thyroid nodules in terms of efficiency, complication rate, influence of preablative nodule size, parameters influencing the therapeutic success and hormonal-thyroid-function.
Methods
Seventy-two patients with 75 nodules were treated with HIFU at 2 centers from 2014–2019. Median nodule volume was 4.4 ml (range 0.33–53). The therapeutic ultrasound probe (EchoPulse THC900888-H) generated 80–90 °C in the target tissue with 87.6–320.3 J per sonication. Nodal volume was measured at baseline and over 12 months after therapy in a retrospective bicentric-study with long-term follow-up. Hormonal-thyroid function (TSH, T3, T4) was measured before and after ablation. Complications were assessed.
Results
Significant volume reduction (p < 0.05 Wilcoxon-signed-rank test) of thyroid nodules was 38.98% at 3 months, 37.32% at 6 months, 61.54% at 9 months and 60.66% at 12 months. Volume reduction of nodules <3 ml did not differ significantly from nodules >3 ml (p > 0.05 Mann–Whitney test). At 3 months solid nodules had a significant volume reduction of 52.08%, complex nodules of 32.57%, nodules treated under regional anesthesia of 33.07% and under general anesthesia of 49.47%. Hormonal-thyroid function was not influenced significantly by HIFU therapy (p > 0.05 Wilcoxon-signed-rank test). Complication rate was 3.8%. No long-term complications occurred.
Conclusion
Significant volume reduction of thyroid nodules up to 12 months after HIFU was shown. All complications were reversible. Therapy was more efficient in solid than complex nodules and in nodules treated under general anesthesia than with regional anesthesia. Hormonal-thyroid-function was not affected.
Trial registraftion number
2020-1728-evBO. Date of registration: 16.06.2020. Agency: Ethik-Kommission bei der Landesäztekammer Hessen
Similar content being viewed by others
References
C. Happel, W.T. Kranert, B. Bockisch et al. 131I and 99m Tc-Uptake in focal thyroid autonomies Development in Germany since the 1980s. Nuklearmedizin 55, 236–241 (2016)
E. Papini, H. Monpeyssen, A. Frasoldati et al. 2020 European Thyroid Association Clinical Practice Guideline for the use of image-guided ablation in benign thyroid nodules. Eur. Thyroid J. 9, 172–185 (2020)
M. Sennert, C. Happel, H. Korkusuz et al. Further investigation on high-intensity focused ultrasound (HIFU) treatment for thyroid nodules. Academic Radiol. 2, 88–94 (2018)
C. Durante, G. Grani, L. Lamartina, The diagnosis and management of thyroid nodules. JAMA. 319, 914 (2018)
L. Giovanella, A.M. Avram, I. Iakovou et al. EANM practice guideline/SNMMI procedure standard for RAIU and thyroid scintigraphy. Eur. J. Nucl. Med. Mol. Imaging 46, 2514–2525 (2019)
J.H. Yoon, J.Y. Kwak, H.J. Moon et al. The diagnostic accuracy of ultrasound- guided fine-needle aspiration biopsy and the sonographic differences between benign and malignant thyroid nodules 3cm or larger. Thyroid. 21, 993–1000 (2011)
M.A. Al Dawish, A. Alwin Robert, M.A. Thabet et al. Thyroid nodule management: thyroid-stimulating hormone, ultrasound, and cytological classification system for predicting malignancy. Cancer Inform. 17, 1176935118765132 (2018)
L. Delbridge, Solitary thyroid nodule: current management. ANZ J. Surg. 76, 381–386 (2006)
B.R. Haugen, E.K. Alexander, K.C. Bible et al. 2015 American Thyroid Association Management Guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: the American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid 26, 1–133 (2016)
E.J. Ha, H.K. Lim, J.H. Yoon et al. Primary imaging test and appropriate biopsy methods for thyroid nodules: guidelines by Korean Society of Radiology and National Evidence-Based Healthcare Collaborating Agency. Korean J. Radiol. 19, 623–631 (2018)
B.H.H. Lang, A.L.H. Wu, High intensity focused ultrasound (HIFU) ablation of benign thyroid nodules - a systematic review. J. Ther Ultrasound 5, 11 (2017)
C. Durante, G. Costante, G. Lucisano et al. The natural history of benign thyroid nodules. JAMA. 313, 926 (2015)
H. Korkusuz, D. Gröner, N. Racynski et al. Thermal ablation of thyroid nodules: are radiofrequency ablation, microwave ablation and high intensity focused ultrasound equally safe and effective methods? Eur. Radiol. 28, 929–935 (2018)
Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (AWMF) - Federführende Fachgesellschaft Deutsche Gesellschaft für Allgemein- und Viszeralchirurgie (DGAV). Operative Therapie benigner Schilddrüsenerkrankungen. Version vom 03.10.2015. Verfügbar: https://www.awmf.org/uploads/tx_szleitlinien/088-007l_S2k_operative_Therapie_benigner_Schilddrüsenerkrankungen_2015-10-abgelaufen_01.pdf (Zugriff am 26.04.2022)
M. Dietlein, F. Grünwald, M. Schmidt et al. Radioiodtherapie bei benignen Schilddrüsenerkrankungen (Version 5). Nuklearmedizin 55, 213–220 (2016)
C.J. Balentine, R.S. Sippel, Outpatient thyroidectomy. Surg. Oncol. Clin. N. Am. 25, 61–75 (2016)
S.R. Chung, J.H. Baek, C.H. Suh et al. Efficacy and safety of high-intensity focused ultrasound (HIFU) for treating benign thyroid nodules: a systematic review and meta-analysis. SAGE J. 61, 1636–1643 (2016)
H. Korkusuz, Thermoablation von Schilddrüsenknoten. Nuklearmediziner 39, 227–231 (2016)
Z. Izadifar, Z. Izadifar, D. Chapman et al. An introduction to high intensity focused ultrasound: systematic review on principles, devices, and clinical applications. JCM 9, 460 (2020)
G. Haar, C. Coussios, High intensity focused ultrasound: physical principles and devices. Int. J. Hyperth. 23, 89–104 (2007)
C.R. Hill, G.R. Haar, Review article: high intensity focused ultrasound–potential for cancer treatment. Br. J. Radiol. 68, 1296–1303 (1995)
R. Yang, N.T. Sanghvi, F.J. Rescorla et al. Liver cancer ablation with extracorporeal high-intensity focused ultrasound. Eur. Urol. 23, 17–22 (1993)
H. Korkusuz, M. Sennert, N. Fehre et al. Localized thyroid tissue ablation by high intensity focused ultrasound: volume reduction, effects on thyroid function and immune response. Fortschr. Röntgenstr. 187, 1011–1015 (2015)
E. Spartalis, S.P. Karagiannis, N. Plakopitis et al. Single-session high-intensity focused ultrasound (HIFU) ablation for benign thyroid nodules: a systematic review. Expert Rev. Med. Devices 17, 1–13 (2020)
B.H.H. Lang, Y.C. Woo, K.W.H. Chiu, Single-session high-intensity focused ultrasound treatment in large-sized benign thyroid nodules. Thyroid 27, 714–721 (2017)
P. Trimboli, F. Pelloni, F. Bini et al. High-intensity focused ultrasound (HIFU) for benign thyroid nodules: 2-year follow-up results. Endocrine 65, 312–317 (2019)
K. Enomoto, S. Uchino, S. Watanabe et al. Recurrent laryngeal nerve palsy during surgery for benign thyroid diseases: Risk factors and outcome analysis. Surgery 155(3), 522–8 (2014)
D. Lenay-Pinon, A. Biet-Hornstein, V. Strunski, C. Page, The circumstances in which recurrent laryngeal nerve palsy occurs after surgery for benign thyroid disease: a retrospective study of 1026 patients. J. Laryngol. Otol. 135(7), 640–643 (2021)
J.P. Jeannon, A.A. Orabi, G.A. Bruch et al. Diagnosis of recurrent laryngeal nerve palsy after thyroidectomy: a systematic review. Int. J. Clin. Pract. 63(4), 624–9 (2009)
E. Lin, S. Lin, J. Fu et al. Neural monitoring during ultrasound-guided radiofrequency ablation of thyroid nodules. Int. J. Hyperthermia 37(1), 1229–1237 (2020)
C. Kim, J.H. Lee, Y.J. Choi et al. Complications encountered in ultrasonography-guided radiofrequency ablation of benign thyroid nodules and recurrent thyroid cancers. Eur. Radiol. 27, 3128–3137 (2017)
B. Feng, P. Liang, Z. Cheng et al. Ultrasound-guided percutaneous microwave ablation of benign thyroid nodules: experimental and clinical studies. Eur. J. Endocrinol. 166(6), 1031–1037 (2012)
C. Friedrich, C. Ulmer, F. Rieber et al. Safety analysis of vagal nerve stimulation for continuous nerve monitoring during thyroid surgery. Laryngoscope 122(9), 1979–87 (2012)
E. Phelan, R. Schneider, K. Lorenz et al. Continuous vagal IONM prevents recurrent laryngeal nerve paralysis by revealing initial EMG changes of impending neuropraxic injury: a prospective, multicenter study. Laryngoscope 124(6), 1498–505 (2014)
H. Korkusuz, M. Sennert, N. Fehre et al. Local thyroid tissue ablation by high- intensity focused ultrasound: Effects on thyroid function and first human feasibility study with hot and cold thyroid nodules. Int. J. Hyperthermia 30, 480–485 (2014)
M. Dietlein, J. Dressler, F. Grünwald, Leitlinie zur Radioiodtherapie (RIT) bei benignen Schilddrüsenerkrankungen [Guidline for radioiodine therapy (RIT for benign thyroid diseases] (Version 4). Nuklearmedizin 46, 220–23 (2007)
Author information
Authors and Affiliations
Contributions
All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by C.V., A.F. and H.K. The first draft of the manuscript was written by C.V., A.F. and H.K. and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.
Corresponding author
Ethics declarations
Conflict of interest
The authors declare no competing interests.
Ethical approval
This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of University B (Date 16.06.2020/No. 2020-1728-evBO).
Informed consent
Informed consent was obtained from all individual participants included in the study.
Additional information
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Vorländer, C., Fischer, A. & Korkusuz, H. High intensity focused ultrasound in the therapy of benign thyroid nodules—first German bicentric study with long-term follow-up. Endocrine 77, 112–120 (2022). https://doi.org/10.1007/s12020-022-03058-z
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12020-022-03058-z