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The relationship between lipotoxicity and risk of extrathyroidal extension in papillary thyroid microcarcinoma

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Abstract

Objective

To explore the relationship between triglyceride (TG) levels and aggressive pathological characteristics in papillary thyroid microcarcinoma (PTMC) patients, especially the relationship between TG, BMI, age, and extrathyroidal extension (ETE).

Methods

A retrospective analysis of 9663 patients with PTMC in a single center from 2010 to 2017 was included in this study. Binary logistic regression was used to analyze the relationship between serum TG and aggressive pathological characteristics of PTMC in different genders. Further analyzing the risk of high TG in different ages and BMI groups.

Results

Even after adjustment for confounding factors, high TG is still a risk factor for ETE in women with PTMC, but not a risk factor for men. Compared with the group with lower than 0.90 mmol/L, when the TG level is higher than 1.93 mmol/L, the risk of ETE in women increased by about 1.35-fold. The remaining two variables (BMI, age) as risk factors for ETE are analyzed. In the normal BMI group, high TG is still a risk factor for ETE. The risk of ETE in women more than 55 years old is significantly increased by 1.96-fold (1.34-fold in less than 55 years).

Conclusion

High TG in women is positively correlated with the risk of ETE in PTMC. PTMC with high TG in elderly women (more than 55 years) has a higher risk of ETE. TG is a potential serological index for predicting the risk of ETE in women with normal BMI.

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Data availability

The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions.

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Acknowledgements

Thanks to Rui Du, MS, and Chengqiu Sui, MS, for valuable suggestions in academic discussions.

Funding

This study was supported by the grant from Liaoning Provincial Science and Technology Development Program (Grant # 2017225008).

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Authors and Affiliations

  1. Division of Thyroid Surgery, China–Japan Union Hospital of Jilin University, Jilin Provincial Key Laboratory of Surgical Translational Medicine, Jilin Provincial Engineering Laboratory of Thyroid Disease Prevention and Control, Changchun, Jilin Province, China

    Changlin Li, Yishen Zhao, Nan liang, Jiao Zhang & Hui Sun

  2. Department of Endocrinology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, 106 Zhongshan Er Road, Guangzhou, Guangdong, P. R. China

    Haixia Guan

  3. The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, P. R. China

    Haixia Guan

  4. Department of General Surgery, Xiangya Hospital, Central South University, Changsha, China

    Qiao He

  5. Division for Endocrine and Minimally Invasive Surgery, Department of Human Pathology in Adulthood and Childhood “G. Barresi,”, University Hospital G. Martino, University of Messina, Via C. Valeria 1, Messina, Italy

    Gianlorenzo Dionigi

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  1. Changlin Li
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  2. Haixia Guan
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  3. Qiao He
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  7. Gianlorenzo Dionigi
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Contributions

Conception and design: G.D., H.S., H.G.; administrative support: H.S.; collection and assembly of data: Q.H., Y.Z.; data analysis and interpretation: C.L.; manuscript writing: C.L. Final approval of manuscript: all authors.

Corresponding authors

Correspondence to Gianlorenzo Dionigi or Hui Sun.

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The authors declare no competing interests.

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The Institutional Review Board of China–Japan Union Hospital of Jilin University, Changchun, China, approved the protocol (Grant # 2019040806).

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All patients had provided signed informed consent.

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Li, C., Guan, H., He, Q. et al. The relationship between lipotoxicity and risk of extrathyroidal extension in papillary thyroid microcarcinoma. Endocrine 74, 646–657 (2021). https://doi.org/10.1007/s12020-021-02809-8

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