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A nomogram for predicting 5-year incidence of type 2 diabetes in a Chinese population

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Abstract

Purpose

To develop a nomogram for predicting 5-year incidence of type 2 diabetes (T2D) in Chinese adults.

Methods

This is a retrospective cohort study from a prospectively collected database. We included a total 32,766 adults free of T2D at baseline with a median follow-up of 3 years. Univariate and multivariate Cox regression analyses were applied to identify independent predictors. A nomogram was constructed to predict 5-year incident rate of T2D based on the multivariate analysis results. Harrell's C-indexes and calibration plots were used to evaluate the accuracy of the nomogram in both internal and external validations.

Results

The overall prevalence of T2D was 2.1%. Participants were randomly divided into a training set (n = 21,844) and a validation set (n = 10,922). After multivariate analysis in the training set, age, sex, BMI, hypertension, dyslipidemia, smoking status, and family history were found as risk predictors and integrated into the nomogram. Harrell's C-indexes were 0.815 (95% CI: 0.797–0.834) and 0.779 (95% CI: 0.747–0.811) in the training and validation sets, respectively. The calibration plots demonstrated good agreement between the estimated probability and the actual observation.

Conclusion

Our nomogram could be a simple and reliable tool for predicting 5-year risk of developing T2D in high-risk Chinese. Through the model, early identifying high-risk individuals is helpful for timely intervention to reduce the incidence of T2D.

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Author notes

  1. These authors contributed equally: Zeyin Lin, Dongming Guo

Authors and Affiliations

  1. Department of Ultrasound, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China

    Zeyin Lin & Baoqun Zheng

  2. Department of General Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China

    Dongming Guo & Juntian Chen

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  1. Zeyin Lin
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  4. Baoqun Zheng
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Correspondence to Baoqun Zheng.

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The study protocol was approved by the Ethics Committee of The First Affiliated Hospital of Shantou University Medical College, China.

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Lin, Z., Guo, D., Chen, J. et al. A nomogram for predicting 5-year incidence of type 2 diabetes in a Chinese population. Endocrine 67, 561–568 (2020). https://doi.org/10.1007/s12020-019-02154-x

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