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Metabolic syndrome in childhood leukemia survivors: a meta-analysis

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Abstract

A significant number of long-term complications have been described in childhood leukemia survivors. In particular, these patients may present features of metabolic syndrome (MetS), and therefore increased risk for cardiovascular diseases. The aim of this meta-analysis is to evaluate the prevalence and the risk of MetS in survivors of childhood leukemia. Two authors independently performed a systematic literature search in PubMed and EMBASE to March 2014, reviewed and selected articles, based on pre-determined selection criteria. Twelve articles, comprising 2,337 participants (1,462 cases and 875 controls), were included in the meta-analysis. Only three of them were case–control studies eligible for the meta-analysis. The childhood leukemia survivors showed an increased risk of MetS as compared to healthy controls (OR = 4.36; 95 % CI 1.19–16.22). The risk was significantly increased only in patients treated with chemotherapy and radiotherapy (OR = 7.79; 95 % CI 1.27–47.77), and not in patients treated with only chemotherapy (OR = 2.35; 95 % CI 0.40–13.78). Childhood leukemia survivors, in particular if treated also with radiotherapy, are prone to develop MetS more than healthy controls. Monitoring of MetS components in these patients is necessary to avoid cardiovascular consequences later in life.

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Authors and Affiliations

  1. Department of Biomedical Sciences and Human Oncology, Pediatrics Unit, University of Bari ‘A. Moro’, Piazza G. Cesare, 11, 70124, Bari, Italy

    Maria Felicia Faienza, Paola Giordano, Luciano Cavallo & Annamaria Ventura

  2. Paediatrics Unit, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, FG, Italy

    Maurizio Delvecchio

  3. Section of Human Anatomy and Histology, Department of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari ‘A. Moro’, Bari, Italy

    Maria Grano & Giacomina Brunetti

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  1. Maria Felicia Faienza
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  2. Maurizio Delvecchio
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  4. Luciano Cavallo
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Faienza, M.F., Delvecchio, M., Giordano, P. et al. Metabolic syndrome in childhood leukemia survivors: a meta-analysis. Endocrine 49, 353–360 (2015). https://doi.org/10.1007/s12020-014-0395-7

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