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Current and Future Monoclonal Antibodies in the Treatment of Atopic Dermatitis

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Abstract

Atopic dermatitis is a common immunologic skin disease. Mild atopic dermatitis can be managed with emollients and topical therapies such as low potency topical steroids, which have a favorable safety profile. Severe atopic dermatitis, in contrast, is a challenging disease to treat. Topical therapies are typically inadequate for control of severe atopic dermatitis. When topical therapies fail, the mainstay of therapy for severe atopic dermatitis has traditionally been phototherapy or off-label use of systemic immunosuppressant treatment, yet systemic immunosuppressants all have significant potential toxicities, drug interactions, and contraindications, requiring close monitoring. Targeted biologics are therefore attractive treatment options for topical therapy-refractory cases of atopic dermatitis, with the potential to offer effective, safer treatment of uncontrolled atopic dermatitis. Dupilumab, as the only biologic therapy currently FDA-approved for atopic dermatitis, is effective for many patients, but there is need for continuing study of additional biologic therapies to address the needs of diverse patients with uncontrolled atopic dermatitis.

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Abbreviations

AD:

Atopic dermatitis

ADIQ:

Atopic dermatitis impact questionnaire

EASI:

Eczema area and severity index

IGA:

Investigator global assessment

PGA:

Physician’s global assessment

SCORAD:

SCORing Atopic Dermatitis

SQ:

Subcutaneously

VAS:

Visual analog scale

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  1. Division of Allergy, Immunology, and Rheumatology, Department of Pediatrics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA

    Peter Ip Fung Chun & Heather Lehman

  2. Department of Pediatrics, Jacobs School of Medicine and Biomedical Sciences, 1001 Main Street, Buffalo, NY, 14203, USA

    Heather Lehman

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Chun, P.I.F., Lehman, H. Current and Future Monoclonal Antibodies in the Treatment of Atopic Dermatitis. Clinic Rev Allerg Immunol 59, 208–219 (2020). https://doi.org/10.1007/s12016-020-08802-9

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