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The Cutaneous Spectrum of Lupus Erythematosus

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Abstract

Systemic lupus erythematosus is a complex autoimmune disease with a wide spectrum of clinical and immunopathological features. Cutaneous and articular manifestations are the most common signs in patients with systemic lupus erythematosus. We here review the pathogenesis and the new classification of cutaneous lupus erythemathosus with a discussion of the significance of the various cutaneous signs. The lesions are classified according to the level of the cellular infiltrate and tissue damage in the epidermis, dermis, and/or subcutis. Furthermore, cutaneous lesions pointing to the presence of a thrombotic vasculopathy and those due to a distinct inflammatory, neutrophilic-mediated reaction pattern are highlighted. Particular attention will be given in describing the histology of skin manifestation. Treatment options for cutaneous lupus erythemathosus have increased with the introduction of new biological therapies. However, the majority of the patients still benefit from antimalarials, which remain the cornerstone of treatment. The evaluation and management of cutaneous lupus erythemathosus patients depend on the clinical findings and associated symptoms.

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Authors and Affiliations

  1. Department of Medical Sciences, Section of Dermatology, University of Turin, Turin, Italy

    Simone Ribero

  2. Center of Research of Immunopathology and Rare Diseases- Department of Clinical and Biological Sciences, University of Turin, San Giovanni Hospital, Turin, Italy

    Savino Sciascia

  3. Department of Dermatology, University of Bern, Inselspital, Berne, Switzerland

    Luca Borradori

  4. Dermatologic Clinic, Faculty of Medicine, University of Strasbourg, Strasbourg, France

    Dan Lipsker

Authors
  1. Simone Ribero
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  2. Savino Sciascia
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  3. Luca Borradori
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  4. Dan Lipsker
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Correspondence to Simone Ribero.

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Ribero, S., Sciascia, S., Borradori, L. et al. The Cutaneous Spectrum of Lupus Erythematosus. Clinic Rev Allerg Immunol 53, 291–305 (2017). https://doi.org/10.1007/s12016-017-8627-2

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  • DOI: https://doi.org/10.1007/s12016-017-8627-2

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