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Potential Therapeutic Effects of Human Amniotic Epithelial Cells on Gynecological Disorders Leading to Infertility or Abortion

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Abstract

The induction of feto-maternal tolerance, fetal non-immunogenicity, and the regulation of mother’s immune system are essential variables in a successful pregnancy. Fetal membranes have been used as a source of stem cells and biological components in recent decades. Human amniotic epithelial cells (hAEC) have stem/progenitor characteristics like those found in the amniotic membrane. Based on their immunomodulatory capabilities, recent studies have focused on the experimental and therapeutic applications of hAECs in allograft transplantation, autoimmune disorders, and gynecological problems such as recurrent spontaneous abortion (RSA), recurrent implantation failure (RIF), and premature ovarian failure (POF). This review discusses some of the immunomodulatory features and therapeutic potential of hAECs in preventing infertility, miscarriage, and implantation failure by controlling the maternal immune system.

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Funding

This work was supported by the Isfahan University of Medical Sciences, Isfahan, Iran (grant No. 398865).

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Authors and Affiliations

  1. Department of Immunology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

    Fatemeh Rezayat, Nafiseh Esmaeil & Abbas Rezaei

  2. Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran

    Nafiseh Esmaeil

  3. Department of Immunology, School of Medicine, Environment Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, 81744-176, Isfahan, Iran

    Nafiseh Esmaeil

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  1. Fatemeh Rezayat
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  2. Nafiseh Esmaeil
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F.R. and N.E. designed the study. F.R. and N.E. wrote the paper in consultation with A.R. All authors discussed the results and commented on the manuscript.

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Correspondence to Nafiseh Esmaeil.

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Rezayat, F., Esmaeil, N. & Rezaei, A. Potential Therapeutic Effects of Human Amniotic Epithelial Cells on Gynecological Disorders Leading to Infertility or Abortion. Stem Cell Rev and Rep 19, 368–381 (2023). https://doi.org/10.1007/s12015-022-10464-3

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