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SWI/SNF Chromatin Remodelers: Structural, Functional and Mechanistic Implications

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Abstract

The nuclear events of a eukaryotic cell, such as replication, transcription, recombination and repair etc. require the transition of the compactly arranged chromatin into an uncompacted state and vice-versa. This is mediated by post-translational modification of the histones, exchange of histone variants and ATP-dependent chromatin remodeling. The SWI/SNF chromatin remodeling complexes are one of the most well characterized families of chromatin remodelers. In addition to their role in modulating chromatin, they have also been assigned roles in cancer and health-related anomalies such as developmental, neurocognitive, and intellectual disabilities. Owing to their vital cellular and medical connotations, developing an understanding of the structural and functional aspects of the complex becomes imperative. However, due to the intricate nature of higher-order chromatin as well as compositional heterogeneity of the SWI/SNF complex, intra-species isoforms and inter-species homologs, this often becomes challenging. To this end, the present review attempts to present an amalgamated perspective on the discovery, structure, function, and regulation of the SWI/SNF complex.

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Acknowledgements

This work was supported by EMR grants from Department of Science and Technology, India and Indian Council of Medical Research, India to J.S.P. Council of Scientific and Industrial Research (CSIR) is duly acknowledged for fellowships to A.S. and University of Delhi for infrastructure.

Author Contributions

A.S.: wrote the manuscript and figures, S.B.M.: wrote in part, edited and corrected the manuscript, M.M.C.: conceptualization, correction of the manuscript; J.S.P.: conceptualization, designing, flow, correction and formatting.

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Authors and Affiliations

  1. Department of Zoology, University of Delhi, Delhi, 110007, India

    Abhilasha Singh, Sharmila Basu Modak & Madan M. Chaturvedi

  2. SGT University, Gurugram (Delhi-NCR), Haryana, 122505, India

    Madan M. Chaturvedi

  3. Cluster Innovation Centre, University of Delhi, Delhi, 110007, India

    Jogeswar S. Purohit

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  1. Abhilasha Singh
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Singh, A., Modak, S.B., Chaturvedi, M.M. et al. SWI/SNF Chromatin Remodelers: Structural, Functional and Mechanistic Implications. Cell Biochem Biophys 81, 167–187 (2023). https://doi.org/10.1007/s12013-023-01140-5

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