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Heme Oxygenase 1 in Vertebrates: Friend and Foe

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A Correction to this article was published on 06 December 2021

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Abstract

HO-1 is the inducible form of the enzyme heme-oxygenase. HO-1 catalyzes heme breakdown, reducing the levels of this important oxidant molecule and generating antioxidant, anti-inflammatory, and anti-apoptotic byproducts. Thus, HO-1 has been described as an important stress response mechanism during both physiologic and pathological processes. Interestingly, some findings are demonstrating that uncontrolled levels of HO-1 byproducts can be associated with cell death and tissue destruction as well. Furthermore, HO-1 can be located in the nucleus, influencing gene transcription, cellular proliferation, and DNA repair. Here, we will discuss several studies that approach HO-1 effects as a protective or detrimental mechanism in different pathological conditions. In this sense, as the major organs of vertebrates will deal specifically with distinct types of stresses, we discuss the HO-1 role in each of them, exposing the contradictions associated with HO-1 expression after different insults and circumstances.

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    Rafael Cardoso Maciel Costa Silva & Leonardo Holanda Travassos Correa

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Costa Silva, R.C.M., Correa, L.H.T. Heme Oxygenase 1 in Vertebrates: Friend and Foe. Cell Biochem Biophys 80, 97–113 (2022). https://doi.org/10.1007/s12013-021-01047-z

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