Abstract
Asthma is a heterogeneous pulmonary disease that has constantly increased in prevalence over the past several decades. Primary symptoms include airway constriction, airway hyperresponsiveness, and airway remodeling with additional symptoms such as shortness of breath, wheezing, and difficulty breathing. Allergic asthma involves chronic inflammation of the lungs, and the rise in its yearly diagnosis is potentially associated with the increased global consumption of foods similar to the western diet. Thus, there is growing interest into the link between diet and asthma symptoms, with mounting evidence for an important modulatory role for dietary lipids. Lipids can act as biological mediators in both a proinflammatory and proresolution capacity. Fatty acids play key roles in signaling and in the production of mediators in the allergic and inflammatory pathways. The western diet leads to a disproportionate ω-6:ω-3 ratio, with drastically increased ω-6 levels. To counteract this, consumption of fish and fish oil and the use of dietary oils with anti-inflammatory properties such as olive and sesame oil can increase ω-3 and decrease ω-6 levels. Increasing vitamin intake, lowering LDL cholesterol levels, and limiting consumption of oxidized lipids can help reduce the risk of asthma and the exacerbation of asthmatic symptoms. These dietary changes can be achieved by increasing intake of fruits, vegetables, nuts, oily fish, seeds, animal-related foods (eggs, liver), cheeses, grains, oats, and seeds, and decreasing consumption of fried foods (especially fried in reused oils), fast foods, and heavily processed foods.
Similar content being viewed by others
References
Maslan, J., & Mims, J. W. (2014). What is asthma? Pathophysiology, demographics, and health care costs. Otolaryngologic Clinics of North America, 47(1), 13–22. https://doi.org/10.1016/j.otc.2013.09.010.
Holgate, S. T. (2010). A brief history of asthma and its mechanisms to modern concepts of disease pathogenesis. Allergy, Asthma & Immunology Research, 2(3), 165–171. https://doi.org/10.4168/aair.2010.2.3.165.
Mims, J. W. (2015). Asthma: definitions and pathophysiology. International Forum of Allergy & Rhinology, 5(Suppl 1), S2–S6. https://doi.org/10.1002/alr.21609.
Kuruvilla, M. E., Lee, F. E., & Lee, G. B. (2019). Understanding asthma phenotypes, endotypes, and mechanisms of disease. Clinical Reviews In Allergy & Immunology, 56(2), 219–233. https://doi.org/10.1007/s12016-018-8712-1.
King-Biggs, M. B. (2019). Asthma. Annals of Internal Medicine, 171(7), ITC49–ITC64. https://doi.org/10.7326/AITC201910010.
Moraes, T. J., Sears, M. R., & Subbarao, P. (2018). Epidemiology of asthma and influence of ethnicity. Seminars in Respiratory and Critical Care Medicine, 39(1), 3–11. https://doi.org/10.1055/s-0037-1618568.
Barnes, P. J. (2017). Cellular and molecular mechanisms of asthma and COPD. Clinical Science, 131(13), 1541–1558. https://doi.org/10.1042/CS20160487.
Varraso, R. (2012). Nutrition and asthma. Current Allergy and Asthma Reports, 12(3), 201–210. https://doi.org/10.1007/s11882-012-0253-8.
Wood, L. G. (2017). Diet, obesity, and asthma. Annals of the American Thoracic Society, 14(Suppl 5), S332–S338. https://doi.org/10.1513/AnnalsATS.201702-124AW.
Dixon, A. E., & Holguin, F. (2019). Diet and metabolism in the evolution of asthma and obesity. Clinics in Chest Medicine, 40(1), 97–106. https://doi.org/10.1016/j.ccm.2018.10.007.
Trompette, A., Gollwitzer, E. S., Yadava, K., Sichelstiel, A. K., Sprenger, N., Ngom-Bru, C., Blanchard, C., Junt, T., Nicod, L. P., Harris, N. L., & Marsland, B. J. (2014). Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis. Nature Medicine, 20(2), 159–166. https://doi.org/10.1038/nm.3444.
Halnes, I., Baines, K. J., Berthon, B. S., MacDonald-Wicks, L. K., Gibson, P. G., & Wood, L. G. (2017). Soluble fibre meal challenge reduces airway inflammation and expression of GPR43 and GPR41 in asthma. Nutrients, 9(1), 57. https://doi.org/10.3390/nu9010057.
Chen, J. H., Huang, P. H., Lee, C. C., Chen, P. Y., & Chen, H. C. (2013). A bovine whey protein extract can induce the generation of regulatory T cells and shows potential to alleviate asthma symptoms in a murine asthma model. The British Journal of Nutrition, 109(10), 1813–1820. https://doi.org/10.1017/S0007114512003947.
Hosseini, B., Berthon, B. S., Wark, P., & Wood, L. G. (2017). Effects of fruit and vegetable consumption on risk of asthma, wheezing and immune responses: a systematic review and meta-analysis. Nutrients, 9(4), 341. https://doi.org/10.3390/nu9040341.
O'Keefe, J. H., DiNicolantonio, J. J., & Lavie, C. J. (2018). Coffee for cardioprotection and longevity. Progress in Cardiovascular Diseases, 61(1), 38–42. https://doi.org/10.1016/j.pcad.2018.02.002.
Ahmed, H. M. (2018). Ethnomedicinal, phytochemical and pharmacological investigations of Perilla frutescens (L.) Britt. Molecules, 24(1), 102. https://doi.org/10.3390/molecules24010102.
Zilaee, M., Hosseini, S. A., Jafarirad, S., Abolnezhadian, F., Cheraghian, B., Namjoyan, F., & Ghadiri, A. (2019). An evaluation of the effects of saffron supplementation on the asthma clinical symptoms and asthma severity in patients with mild and moderate persistent allergic asthma: a double-blind, randomized placebo-controlled trial. Respiratory Research, 20(1), 39. https://doi.org/10.1186/s12931-019-0998-x.
Ahmad, M. F., Ahmad, F. A., Ashraf, S. A., Saad, H. H., Wahab, S., Khan, M. I., Ali, M., Mohan, S., Hakeem, K. R., & Athar, M. T. (2021). An updated knowledge of Black seed (Nigella sativa Linn.): review of phytochemical constituents and pharmacological properties. Journal of Herbal Medicine, 25, 100404. https://doi.org/10.1016/j.hermed.2020.100404.
Hsieh, C. C., Kuo, C. H., Kuo, H. F., Chen, Y. S., Wang, S. L., Chao, D., Lee, M. S., & Hung, C. H. (2014). Sesamin suppresses macrophage-derived chemokine expression in human monocytes via epigenetic regulation. Food & Function, 5(10), 2494–2500. https://doi.org/10.1039/c4fo00322e.
Urushidate, S., Matsuzaka, M., Okubo, N., Iwasaki, H., Hasebe, T., Tsuya, R., Iwane, K., Inoue, R., Yamai, K., Danjo, K., Takahashi, I., Umeda, T., Ando, S., Itai, K., & Nakaji, S. (2010). Association between concentration of trace elements in serum and bronchial asthma among Japanese general population. Journal of Trace Elements in Medicine and Biology, 24(4), 236–242. https://doi.org/10.1016/j.jtemb.2010.06.001.
Mao, S., Wu, L., & Shi, W. (2018). Association between trace elements levels and asthma susceptibility. Respiratory Medicine, 145, 110–119. https://doi.org/10.1016/j.rmed.2018.10.028.
Hufnagl, K., & Jensen-Jarolim, E. (2019). Does a carrot a day keep the allergy away? Immunology letters, 206, 54–58. https://doi.org/10.1016/j.imlet.2018.10.009.
Marquez, H. A., & Cardoso, W. V. (2016). Vitamin A-retinoid signaling in pulmonary development and disease. Molecular and Cellular Pediatrics, 3(1), 28. https://doi.org/10.1186/s40348-016-0054-6.
Maslova, E., Hansen, S., Strøm, M., Halldorsson, T. I., & Olsen, S. F. (2014). Maternal intake of vitamins A, E and K in pregnancy and child allergic disease: a longitudinal study from the Danish National Birth Cohort. The British Journal of Nutrition, 111(6), 1096–1108. https://doi.org/10.1017/S0007114513003395.
Pfeffer, P. E., & Hawrylowicz, C. M. (2018). Vitamin D in asthma: mechanisms of action and considerations for clinical trials. Chest, 153(5), 1229–1239. https://doi.org/10.1016/j.chest.2017.09.005.
Litonjua, A. A. (2012). Fat-soluble vitamins and atopic disease: what is the evidence? The Proceedings of the Nutrition Society, 71(1), 67–74. https://doi.org/10.1017/S002966511100334X.
Stone, Jr, C. A., Cook-Mills, J., Gebretsadik, T., Rosas-Salazar, C., Turi, K., Brunwasser, S. M., Connolly, A., Russell, P., Liu, Z., Costello, K., & Hartert, T. V. (2019). Delineation of the individual effects of vitamin E isoforms on early life incident wheezing. The Journal of Pediatrics, 206, 156–163.e3. https://doi.org/10.1016/j.jpeds.2018.10.045.
Cook-Mills, J., Gebretsadik, T., Abdala-Valencia, H., Green, J., Larkin, E. K., Dupont, W. D., Shu, X. O., Gross, M., Bai, C., Gao, Y. T., Hartman, T. J., Rosas-Salazar, C., & Hartert, T. (2016). Interaction of vitamin E isoforms on asthma and allergic airway disease. Thorax, 71(10), 954–956. https://doi.org/10.1136/thoraxjnl-2016-208494.
Guerrera, M. P., Volpe, S. L., & Mao, J. J. (2009). Therapeutic uses of magnesium. American Family Physician, 80(2), 157–162.
Norton, R. L., & Hoffmann, P. R. (2012). Selenium and asthma. Molecular Aspects of Medicine, 33(1), 98–106. https://doi.org/10.1016/j.mam.2011.10.003.
Diamant, Z., Aalders, W., Parulekar, A., Bjermer, L., & Hanania, N. A. (2019). Targeting lipid mediators in asthma: time for reappraisal. Current Opinion in Pulmonary Medicine, 25(1), 121–127. https://doi.org/10.1097/MCP.0000000000000544.
Calder, P. C. (2013). Omega-3 polyunsaturated fatty acids and inflammatory processes: nutrition or pharmacology? British Journal of Clinical Pharmacology, 75(3), 645–662. https://doi.org/10.1111/j.1365-2125.2012.04374.x.
Monga, N., Sethi, G. S., Kondepudi, K. K., & Naura, A. S. (2020). Lipid mediators and asthma: scope of therapeutics. Biochemical Pharmacology, 179, 113925. https://doi.org/10.1016/j.bcp.2020.113925.
Kytikova, O., Novgorodtseva, T., Denisenko, Y., Antonyuk, M., & Gvozdenko, T. (2019). Pro-resolving lipid mediators in the pathophysiology of asthma. Medicina, 55(6), 284. https://doi.org/10.3390/medicina55060284.
Miyata, J., & Arita, M. (2015). Role of omega-3 fatty acids and their metabolites in asthma and allergic diseases. Allergology International, 64(1), 27–34. https://doi.org/10.1016/j.alit.2014.08.003.
Adams, S., Lopata, A. L., Smuts, C. M., Baatjies, R., & Jeebhay, M. F. (2018). Relationship between serum omega-3 fatty acid and asthma endpoints. International Journal of Environmental Research and Public Health, 16(1), 43. https://doi.org/10.3390/ijerph16010043.
Brannan, J. D., Bood, J., Alkhabaz, A., Balgoma, D., Otis, J., Delin, I., Dahlén, B., Wheelock, C. E., Nair, P., Dahlén, S. E., & O’Byrne, P. M. (2015). The effect of omega-3 fatty acids on bronchial hyperresponsiveness, sputum eosinophilia, and mast cell mediators in asthma. Chest, 147(2), 397–405. https://doi.org/10.1378/chest.14-1214.
Rago, D., Rasmussen, M. A., Lee-Sarwar, K. A., Weiss, S. T., Lasky-Su, J., Stokholm, J., Bønnelykke, K., Chawes, B. L., & Bisgaard, H. (2019). Fish-oil supplementation in pregnancy, child metabolomics and asthma risk. EBioMedicine, 46, 399–410. https://doi.org/10.1016/j.ebiom.2019.07.057.
Kim, E. K., & Ju, S. Y. (2019). Asthma and dietary intake of fish, seaweeds, and fatty acids in Korean adults. Nutrients, 11(9), 2187. https://doi.org/10.3390/nu11092187.
Stoodley, I., Garg, M., Scott, H., Macdonald-Wicks, L., Berthon, B., & Wood, L. (2019). Higher omega-3 index is associated with better asthma control and lower medication dose: a cross-sectional study. Nutrients, 12(1), 74. https://doi.org/10.3390/nu12010074.
Hansen, S., Strøm, M., Maslova, E., Dahl, R., Hoffmann, H. J., Rytter, D., Bech, B. H., Henriksen, T. B., Granström, C., Halldorsson, T. I., Chavarro, J. E., Linneberg, A., & Olsen, S. F. (2017). Fish oil supplementation during pregnancy and allergic respiratory disease in the adult offspring. The Journal of Allergy and Clinical Immunology, 139(1), 104–111.e4. https://doi.org/10.1016/j.jaci.2016.02.042.
Bisgaard, H., Stokholm, J., Chawes, B. L., Vissing, N. H., Bjarnadóttir, E., Schoos, A. M., Wolsk, H. M., Pedersen, T. M., Vinding, R. K., Thorsteinsdóttir, S., Følsgaard, N. V., Fink, N. R., Thorsen, J., Pedersen, A. G., Waage, J., Rasmussen, M. A., Stark, K. D., Olsen, S. F., & Bønnelykke, K. (2016). Fish oil-derived fatty acids in pregnancy and wheeze and asthma in offspring. The New England Journal of Medicine, 375(26), 2530–2539. https://doi.org/10.1056/NEJMoa1503734.
Best, K. P., Gold, M., Kennedy, D., Martin, J., & Makrides, M. (2016). Omega-3 long-chain PUFA intake during pregnancy and allergic disease outcomes in the offspring: a systematic review and meta-analysis of observational studies and randomized controlled trials. The American Journal of Clinical Nutrition, 103(1), 128–143. https://doi.org/10.3945/ajcn.115.111104.
Sordillo, J. E., Rifas-Shiman, S. L., Switkowski, K., Coull, B., Gibson, H., Rice, M., Platts-Mills, T., Kloog, I., Litonjua, A. A., Gold, D. R., & Oken, E. (2019). Prenatal oxidative balance and risk of asthma and allergic disease in adolescence. The Journal of Allergy and Clinical Immunology, 144(6), 1534–1541.e5. https://doi.org/10.1016/j.jaci.2019.07.044.
Øien, T., Schjelvaag, A., Storrø, O., Johnsen, R., & Simpson, M. R. (2019). Fish consumption at one year of age reduces the risk of eczema, asthma and wheeze at six years of age. Nutrients, 11(9), 1969. https://doi.org/10.3390/nu11091969.
Zhang, G. Q., Liu, B., Li, J., Luo, C. Q., Zhang, Q., Chen, J. L., Sinha, A., & Li, Z. Y. (2017). Fish intake during pregnancy or infancy and allergic outcomes in children: a systematic review and meta-analysis. Pediatric Allergy and Immunology, 28(2), 152–161. https://doi.org/10.1111/pai.12648.
Hansell, A. L., Bakolis, I., Cowie, C. T., Belousova, E. G., Ng, K., Weber-Chrysochoou, C., Britton, W. J., Leeder, S. R., Tovey, E. R., Webb, K. L., Toelle, B. G., & Marks, G. B. (2018). Childhood fish oil supplementation modifies associations between traffic related air pollution and allergic sensitisation. Environmental Health, 17(1), 27. https://doi.org/10.1186/s12940-018-0370-5.
Hsu, D. Z., Liu, C. T., Chu, P. Y., Li, Y. H., Periasamy, S., & Liu, M. Y. (2013). Sesame oil attenuates ovalbumin-induced pulmonary edema and bronchial neutrophilic inflammation in mice. BioMed Research International, 2013, 905670. https://doi.org/10.1155/2013/905670.
Li, L., Piao, H., Zheng, M., Jin, Z., Zhao, L., & Yan, G. (2016). Sesamin attenuates allergic airway inflammation through the suppression of nuclear factor-kappa B activation. Experimental and Therapeutic Medicine, 12(6), 4175–4181. https://doi.org/10.3892/etm.2016.3903.
Lin, C. H., Shen, M. L., Zhou, N., Lee, C. C., Kao, S. T., & Wu, D. C. (2014). Protective effects of the polyphenol sesamin on allergen-induced T(H)2 responses and airway inflammation in mice. PLoS ONE, 9(4), e96091. https://doi.org/10.1371/journal.pone.0096091.
Liou, C. J., Chen, Y. L., Yu, M. C., Yeh, K. W., Shen, S. C., & Huang, W. C. (2020). Sesamol alleviates airway hyperresponsiveness and oxidative stress in asthmatic mice. Antioxidants, 9(4), 295. https://doi.org/10.3390/antiox9040295.
Lee, S. Y., Bae, C. S., Seo, N. S., Na, C. S., Yoo, H. Y., Oh, D. S., Bae, M. S., Kwon, M. S., Cho, S. S., & Park, D. H. (2019). Camellia japonica oil suppressed asthma occurrence via GATA-3 & IL-4 pathway and its effective and major component is oleic acid. Phytomedicine, 57, 84–94. https://doi.org/10.1016/j.phymed.2018.12.004.
Mazzocchi, A., Leone, L., Agostoni, C., & Pali-Schöll, I. (2019). The secrets of the Mediterranean diet. Does [only] olive oil matter? Nutrients, 11(12), 2941. https://doi.org/10.3390/nu11122941.
Cazzoletti, L., Zanolin, M. E., Spelta, F., Bono, R., Chamitava, L., Cerveri, I., Garcia-Larsen, V., Grosso, A., Mattioli, V., Pirina, P., & Ferrari, M. (2019). Dietary fats, olive oil and respiratory diseases in Italian adults: a population-based study. Clinical and Experimental Allergy, 49(6), 799–807. https://doi.org/10.1111/cea.13352.
Nagel, G., & Linseisen, J. (2005). Dietary intake of fatty acids, antioxidants and selected food groups and asthma in adults. European Journal of Clinical Nutrition, 59(1), 8–15. https://doi.org/10.1038/sj.ejcn.1602025.
Morvaridi, M., Jafarirad, S., Seyedian, S. S., Alavinejad, P., & Cheraghian, B. (2020). The effects of extra virgin olive oil and canola oil on inflammatory markers and gastrointestinal symptoms in patients with ulcerative colitis. European Journal of Clinical Nutrition, 74(6), 891–899. https://doi.org/10.1038/s41430-019-0549-z.
Antunes, M. M., Godoy, G., Fernandes, I. L., Manin, L. P., Zappielo, C., Masi, L. N., Oliveira, V., Visentainer, J. V., Curi, R., & Bazotte, R. B. (2020). The dietary replacement of soybean oil by canola oil does not prevent liver fatty acid accumulation and liver inflammation in mice. Nutrients, 12(12), 3667. https://doi.org/10.3390/nu12123667.
Navarro-Xavier, R. A., de Barros, K. V., de Andrade, I. S., Palomino, Z., Casarini, D. E., & Flor Silveira, V. L. (2016). Protective effect of soybean oil- or fish oil-rich diets on allergic airway inflammation. Journal of Inflammation Research, 9, 79–89. https://doi.org/10.2147/JIR.S102221.
Samarasinghe, A. E., Penkert, R. R., Hurwitz, J. L., Sealy, R. E., LeMessurier, K. S., Hammond, C., Dubin, P. J., & Lew, D. B. (2020). Questioning cause and effect: children with severe asthma exhibit high levels of inflammatory biomarkers including beta-hexosaminidase, but low levels of vitamin A and immunoglobulins. Biomedicines, 8(10), 393. https://doi.org/10.3390/biomedicines8100393.
Andino, D., Moy, J., & Gaynes, B. I. (2019). Serum vitamin A, zinc and visual function in children with moderate to severe persistent asthma. The Journal of Asthma, 56(11), 1198–1203. https://doi.org/10.1080/02770903.2018.1531992.
Niu, C., Liu, N., Liu, J., Zhang, M., Ying, L., Wang, L., Tian, D., Dai, J., Luo, Z., Liu, E., Zou, L., & Fu, Z. (2016). Vitamin A maintains the airway epithelium in a murine model of asthma by suppressing glucocorticoid-induced leucine zipper. Clinical and Experimental Allergy, 46(6), 848–860. https://doi.org/10.1111/cea.12646.
Solidoro, P., Bellocchia, M., & Facchini, F. (2016). The immunobiological and clinical role of vitamin D in obstructive lung diseases. Minerva Medica, 107(3 Suppl 1), 12–19.
Castro, M., King, T. S., Kunselman, S. J., Cabana, M. D., Denlinger, L., Holguin, F., Kazani, S. D., Moore, W. C., Moy, J., Sorkness, C. A., Avila, P., Bacharier, L. B., Bleecker, E., Boushey, H. A., Chmiel, J., Fitzpatrick, A. M., Gentile, D., Hundal, M., Israel, E., & Kraft, M., National Heart, Lung, and Blood Institute’s AsthmaNet. (2014). Effect of vitamin D3 on asthma treatment failures in adults with symptomatic asthma and lower vitamin D levels: the VIDA randomized clinical trial. JAMA, 311(20), 2083–2091. https://doi.org/10.1001/jama.2014.5052.
Wang, M., Liu, M., Wang, C., Xiao, Y., An, T., Zou, M., & Cheng, G. (2019). Association between vitamin D status and asthma control: a meta-analysis of randomized trials. Respiratory Medicine, 150, 85–94. https://doi.org/10.1016/j.rmed.2019.02.016.
Ozturk Thomas, G., Tutar, E., Tokuc, G., & Oktem, S. (2019). 25-hydroxy vitamin D levels in pediatric asthma patients and its link with asthma severity. Cureus, 11(3), e4302. https://doi.org/10.7759/cureus.4302.
Liu, J., Dong, Y. Q., Yin, J., Yao, J., Shen, J., Sheng, G. J., Li, K., Lv, H. F., Fang, X., & Wu, W. F. (2019). Meta-analysis of vitamin D and lung function in patients with asthma. Respiratory Research, 20(1), 161. https://doi.org/10.1186/s12931-019-1072-4.
Ozkars, M. Y., Keskin, O., Almacioglu, M., Kucukosmanoglu, E., Keskin, M., & Balci, O. (2019). The relationship between serum vitamin D level and asthma. Northern Clinics of Istanbul, 6(4), 334–340. https://doi.org/10.14744/nci.2019.82195.
Litonjua, A. A. (2019). Vitamin D and childhood asthma: causation and contribution to disease activity. Current Opinion in Allergy and Clinical Immunology, 19(2), 126–131. https://doi.org/10.1097/ACI.0000000000000509.
Jensen, M. E., Murphy, V. E., Gibson, P. G., Mattes, J., & Camargo, Jr, C. A. (2019). Vitamin D status in pregnant women with asthma and its association with adverse respiratory outcomes during infancy. The Journal of Maternal-fetal & Neonatal Medicine, 32(11), 1820–1825. https://doi.org/10.1080/14767058.2017.1419176.
Adams, S. N., Adgent, M. A., Gebretsadik, T., Hartman, T. J., Vereen, S., Ortiz, C., Tylavsky, F. A., & Carroll, K. N. (2021). Prenatal vitamin D levels and child wheeze and asthma. The Journal of Maternal-fetal & Neonatal Medicine, 34(3), 323–331. https://doi.org/10.1080/14767058.2019.1607286.
Lewis, E. D., Meydani, S. N., & Wu, D. (2019). Regulatory role of vitamin E in the immune system and inflammation. IUBMB Life, 71(4), 487–494. https://doi.org/10.1002/iub.1976.
Kurti, S. P., Murphy, J. D., Ferguson, C. S., Brown, K. R., Smith, J. R., & Harms, C. A. (2016). Improved lung function following dietary antioxidant supplementation in exercise-induced asthmatics. Respiratory Physiology & Neurobiology, 220, 95–101. https://doi.org/10.1016/j.resp.2015.09.012.
Larkin, E. K., Gao, Y. T., Gebretsadik, T., Hartman, T. J., Wu, P., Wen, W., Yang, G., Bai, C., Jin, M., Roberts, 2nd, L. J., Gross, M., Shu, X. O., & Hartert, T. V. (2015). New risk factors for adult-onset incident asthma. A nested case-control study of host antioxidant defense. American Journal of Respiratory and Critical Care Medicine, 191(1), 45–53. https://doi.org/10.1164/rccm.201405-0948OC.
Wu, H., Zhang, C., Wang, Y., & Li, Y. (2018). Does vitamin E prevent asthma or wheeze in children: a systematic review and meta-analysis. Paediatric Respiratory Reviews, 27, 60–68. https://doi.org/10.1016/j.prrv.2017.08.002.
Allan, K. M., Prabhu, N., Craig, L. C., McNeill, G., Kirby, B., McLay, J., Helms, P. J., Ayres, J. G., Seaton, A., Turner, S. W., & Devereux, G. (2015). Maternal vitamin D and E intakes during pregnancy are associated with asthma in children. The European Respiratory Journal, 45(4), 1027–1036. https://doi.org/10.1183/09031936.00102214.
Devereux, G., Craig, L., Seaton, A., & Turner, S. (2019). Maternal vitamin D and E intakes in pregnancy and asthma to age 15 years: a cohort study. Pediatric Pulmonology, 54(1), 11–19. https://doi.org/10.1002/ppul.24184.
Feingold, K. R. Introduction to Lipids and Lipoproteins. (2021). In: K. R. Feingold, B. Anawalt, A. Boyce, G. Chrousos, WW. de Herder, K. Dhatariya, K. Dungan, A. Grossman, JM. Hershman, J. Hofland, S. Kalra, G. Kaltsas, C. Koch, P. Kopp, M. Korbonits, C.S. Kovacs, W. Kuohung, B. Laferrère, E.A. McGee, R. McLachlan, J.E. Morley, M. New, J. Purnell, R. Sahay, F. Singer, C.A. Stratakis, D. L. Trence, D.P. Wilson, (eds). South Dartmouth (MA): MDText.com, Inc.
Staprans, I., Pan, X. M., Rapp, J. H., & Feingold, K. R. (2005). The role of dietary oxidized cholesterol and oxidized fatty acids in the development of atherosclerosis. Molecular Nutrition & Food Research, 49(11), 1075–1082. https://doi.org/10.1002/mnfr.200500063.
Ramaraju, K., Krishnamurthy, S., Maamidi, S., Kaza, A. M., & Balasubramaniam, N. (2013). Is serum cholesterol a risk factor for asthma? Lung India, 30(4), 295–301. https://doi.org/10.4103/0970-2113.120604.
Stokes, K. Y., Cooper, D., Tailor, A., & Granger, D. N. (2002). Hypercholesterolemia promotes inflammation and microvascular dysfunction: role of nitric oxide and superoxide. Free Radical Biology & Medicine, 33(8), 1026–1036. https://doi.org/10.1016/s0891-5849(02)01015-8.
Al-Shawwa, B., Al-Huniti, N., Titus, G., & Abu-Hasan, M. (2006). Hypercholesterolemia is a potential risk factor for asthma. The Journal of Asthma, 43(3), 231–233. https://doi.org/10.1080/02770900600567056.
Schäfer, T., Ruhdorfer, S., Weigl, L., Wessner, D., Heinrich, J., Döring, A., Wichmann, H. E., & Ring, J. (2003). Intake of unsaturated fatty acids and HDL cholesterol levels are associated with manifestations of atopy in adults. Clinical and Experimental Allergy, 33(10), 1360–1367. https://doi.org/10.1046/j.1365-2222.2003.01780.x.
Yiallouros, P. K., Savva, S. C., Kolokotroni, O., Behbod, B., Zeniou, M., Economou, M., Chadjigeorgiou, C., Kourides, Y. A., Tornaritis, M. J., Lamnisos, D., Middleton, N., & Milton, D. K. (2012). Low serum high-density lipoprotein cholesterol in childhood is associated with adolescent asthma. Clinical and Experimental Allergy, 42(3), 423–432. https://doi.org/10.1111/j.1365-2222.2011.03940.x.
Fessler, M. B., Massing, M. W., Spruell, B., Jaramillo, R., Draper, D. W., Madenspacher, J. H., Arbes, S. J., Calatroni, A., & Zeldin, D. C. (2009). Novel relationship of serum cholesterol with asthma and wheeze in the United States. The Journal of Allergy and Clinical Immunology, 124(5), 967–74.e1-15. https://doi.org/10.1016/j.jaci.2009.08.005.
Andersen, C. J. (2018). Impact of dietary cholesterol on the pathophysiology of infectious and autoimmune disease. Nutrients, 10(6), 764. https://doi.org/10.3390/nu10060764.
Gowdy, K. M., & Fessler, M. B. (2013). Emerging roles for cholesterol and lipoproteins in lung disease. Pulmonary Pharmacology & Therapeutics, 26(4), 430–437. https://doi.org/10.1016/j.pupt.2012.06.002.
Gao, S., Wang, C., Li, W., Shu, S., Zhou, J., Yuan, Z., & Wang, L. (2019). Allergic asthma aggravated atherosclerosis increases cholesterol biosynthesis and foam cell formation in apolipoprotein E-deficient mice. Biochemical and Biophysical Research Communications, 519(4), 861–867. https://doi.org/10.1016/j.bbrc.2019.09.085.
Tuleta, I., Skowasch, D., Aurich, F., Eckstein, N., Schueler, R., Pizarro, C., Schahab, N., Nickenig, G., Schaefer, C., & Pingel, S. (2017). Asthma is associated with atherosclerotic artery changes. PLoS ONE, 12(10), e0186820. https://doi.org/10.1371/journal.pone.0186820.
Han, W., Li, J., Tang, H., & Sun, L. (2017). Treatment of obese asthma in a mouse model by simvastatin is associated with improving dyslipidemia and decreasing leptin level. Biochemical and Biophysical Research Communications, 484(2), 396–402. https://doi.org/10.1016/j.bbrc.2017.01.135.
Dobarganes, C., & Márquez-Ruiz, G. (2003). Oxidized fats in foods. Current Opinion in Clinical Nutrition and Metabolic Care, 6(2), 157–163. https://doi.org/10.1097/00075197-200303000-00004.
Mozuraityte, R., Kristinova, V., & Rustad, T. (2016). Oxidation of food components. Encyclopedia of Food and Health, 186–190. https://doi.org/10.1016/b978-0-12-384947-2.00508-0.
Nwanguma, B. C., Achebe, A. C., Ezeanyika, L. U., & Eze, L. C. (1999). Toxicity of oxidized fats II: tissue levels of lipid peroxides in rats fed a thermally oxidized corn oil diet. Food and Chemical Toxicology, 37(4), 413–416. https://doi.org/10.1016/s0278-6915(99)00023-x.
Huang, W. C., Kang, Z. C., Li, Y. J., & Shaw, H. M. (2009). Effects of oxidized frying oil on proteins related to alpha-tocopherol metabolism in rat liver. Journal of Clinical Biochemistry and Nutrition, 45(1), 20–28. https://doi.org/10.3164/jcbn08-250.
Hayam, I., Cogan, U., & Mokady, S. (1997). Enhanced peroxidation of proteins of the erythrocyte membrane and of muscle tissue by dietary oxidized oil. Bioscience, Biotechnology, and Biochemistry, 61(6), 1011–1012. https://doi.org/10.1271/bbb.61.1011.
Ogino, H., Sakazaki, F., Okuno, T., Arakawa, T., & Ueno, H. (2015). Oxidized dietary oils enhance immediate- and/or delayed-type allergic reactions in BALB/c mice. Allergology International, 64(1), 66–72. https://doi.org/10.1016/j.alit.2014.07.004.
Lin, B. F., Lai, C. C., Lin, K. W., & Chiang, B. L. (2000). Dietary oxidized oil influences the levels of type 2 T-helper cell-related antibody and inflammatory mediators in mice. The British Journal of Nutrition, 84(6), 911–917.
Svedahl, S., Svendsen, K., Qvenild, T., Sjaastad, A. K., & Hilt, B. (2009). Short term exposure to cooking fumes and pulmonary function. Journal of Occupational Medicine and Toxicology, 4, 9. https://doi.org/10.1186/1745-6673-4-9.
Oldenburger, D., Maurer, W. J., Beltaos, E., & Magnin, G. E. (1972). Inhalation lipoid pneumonia from burning fats. A newly recognized industrial hazard. JAMA, 222(10), 1288–1289.
Svendsen, K., Sjaastad, A. K., & Sivertsen, I. (2003). Respiratory symptoms in kitchen workers. American Journal of Industrial Medicine, 43(4), 436–439. https://doi.org/10.1002/ajim.10197.
Ng, T. P., Hui, K. P., & Tan, W. C. (1993). Respiratory symptoms and lung function effects of domestic exposure to tobacco smoke and cooking by gas in non-smoking women in Singapore. Journal of Epidemiology and Community Health, 47(6), 454–458. https://doi.org/10.1136/jech.47.6.454.
Zahir, E., Saeed, R., Hameed, M. A., & Yousuf, A. (2017). Study of physicochemical properties of edible oil and evaluation of frying oil quality by Fourier transform-infrared (FT-IR) spectroscopy. Arabian Journal of Chemistry, 10, S3870–S3876. https://doi.org/10.1016/j.arabjc.2014.05.025.
Cohn, J. S. (2002). Oxidized fat in the diet, postprandial lipaemia and cardiovascular disease. Current Opinion in Lipidology, 13(1), 19–24. https://doi.org/10.1097/00041433-200202000-00004.
Ursini, F., Zamburlini, A., Cazzolato, G., Maiorino, M., Bon, G. B., & Sevanian, A. (1998). Postprandial plasma lipid hydroperoxides: a possible link between diet and atherosclerosis. Free Radical Biology & Medicine, 25(2), 250–252. https://doi.org/10.1016/s0891-5849(98)00044-6.
Alwarith, J., Kahleova, H., Crosby, L., Brooks, A., Brandon, L., Levin, S. M., & Barnard, N. D. (2020). The role of nutrition in asthma prevention and treatment. Nutrition Reviews, 78(11), 928–938. https://doi.org/10.1093/nutrit/nuaa005.
Guilleminault, L., Williams, E. J., Scott, H. A., Berthon, B. S., Jensen, M., & Wood, L. G. (2017). Diet and asthma: is it time to adapt our message? Nutrients, 9(11), 1227 https://doi.org/10.3390/nu9111227.
Spector, S. L., & Surette, M. E. (2003). Diet and asthma: has the role of dietary lipids been overlooked in the management of asthma? Annals of Allergy, Asthma & Immunology, 90(4), 371–421. https://doi.org/10.1016/S1081-1206(10)61817-0.
Wendell, S. G., Baffi, C., & Holguin, F. (2014). Fatty acids, inflammation, and asthma. The Journal of Allergy and Clinical Immunology, 133(5), 1255–1264. https://doi.org/10.1016/j.jaci.2013.12.1087.
Devereux, G., & Seaton, A. (2005). Diet as a risk factor for atopy and asthma. The Journal of Allergy and Clinical Immunology, 115(6), 1109–1118. https://doi.org/10.1016/j.jaci.2004.12.1139.
Parr, C. L., Magnus, M. C., Karlstad, Ø., Holvik, K., Lund-Blix, N. A., Haugen, M., Page, C. M., Nafstad, P., Ueland, P. M., London, S. J., Håberg, S. E., & Nystad, W. (2018). Vitamin A and D intake in pregnancy, infant supplementation, and asthma development: the Norwegian Mother and Child Cohort. The American Journal of Clinical Nutrition, 107(5), 789–798. https://doi.org/10.1093/ajcn/nqy016.
Chen, Y. C., Tung, K. Y., Tsai, C. H., Su, M. W., Wang, P. C., Chen, C. H., & Lee, Y. L. (2013). Lipid profiles in children with and without asthma: interaction of asthma and obesity on hyperlipidemia. Diabetes & Metabolic Syndrome, 7(1), 20–25. https://doi.org/10.1016/j.dsx.2013.02.026.
Ko, S. H., Jeong, J., Baeg, M. K., Han, K. D., Kim, H. S., Yoon, J. S., Kim, H. H., Kim, J. T., & Chun, Y. H. (2018). Lipid profiles in adolescents with and without asthma: Korea National Health and nutrition examination survey data. Lipids in Health and Disease, 17(1), 158. https://doi.org/10.1186/s12944-018-0807-4.
Vieira, S. A., McClements, D. J., & Decker, E. A. (2015). Challenges of utilizing healthy fats in foods. Advances in Nutrition, 6(3), 309S–317SS. https://doi.org/10.3945/an.114.006965.
Acknowledgements
The authors acknowledge support provided by the Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, and the Dorothy M. Davis Heart & Lung Research Institute of the Ohio State University Wexner Medical Center.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing Interests
The authors declare no competing interests.
Additional information
This study is dedicated to Professor Viswanathan Natarajan of the University of Illinois at Chicago for his 50 years of research contribution to lipidology and biochemistry and mentoring students, postdoctoral fellows, and faculty.
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Oliver, P.J., Arutla, S., Yenigalla, A. et al. Lipid Nutrition in Asthma. Cell Biochem Biophys 79, 669–694 (2021). https://doi.org/10.1007/s12013-021-01020-w
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12013-021-01020-w