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Serum Uric Acid and Impaired Glucose Tolerance: The Cardiometabolic Risk in Chinese (CRC) Study

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Abstract

Serum uric acid (SUA) elevation has been previously related to impaired fasting glucose and type 2 diabetes. The present study was comprehensive to examine the associations between SUA and impaired glucose tolerance (IGT) in Chinese adults. For this purpose, data were collected from a community-based health examination survey conducted in Central China; 2-h glucose (OGTT) and SUA were measured in 1956 men and women. In multivariate models, SUA levels were significantly associated with an increasing trend of 2-h glucose (OGTT) (P for trend < 0.0001). The odds ratios (OR; 95 % CI) of IGT across increasing quartiles of SUA were 1.0, 1.354 (0.948–2.087), 1.337 (0.959–2.251), and 2.192 (1.407–3.416), after adjusting for age, sex, body mass index, waist circumference, fasting insulin, blood pressure, serum lipids, serum creatinine, and estimated glomerular filtration rate. (P for trend = 0.001). In addition, we found an additive pattern between SUA and triglyceride (TG; P = 0.038) or between SUA and low-density lipoprotein cholesterol (LDL-C; P = 0.041) in relation to IGT. SUA was related to IGT in the Chinese adults, independent of other conventional metabolic risk factors. TG and LDL-C might modify the associations.

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Abbreviations

SUA:

Serum uric acid

IGT:

Impaired glucose tolerance

2-h glucose (OGTT):

2-hour glucose (oral glucose tolerance test)

BMI:

Body mass index

WC:

Waist circumference

SBP:

Systolic blood pressure

DBP:

Diastolic blood pressure

HOMA-IR:

Homeostasis model assessment of insulin resistance

HbA1c:

Glycated hemoglobin

FBG:

Fasting blood glucose

FPG:

Fasting plasma glucose

FINS:

Fasting insulin

TC:

Total cholesterol

TG:

Triglycerides

HDL-C:

High-density lipoprotein cholesterol

LDL-C:

Low-density lipoprotein cholesterol

OR:

Odds ratio

CI:

Confidence interval

eGFR:

Estimated glomerular filtration rate

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Acknowledgments

The authors are thankful to Lu Qi for critical comments, help with language, and proof reading of the manuscript. We also thank all our study participants. This work was supported by grants from Jiangsu Provincial Bureau of Health Foundation (# H201356), International Exchange Program and Jiangsu Six Talent Peaks Program (# 2013-WSN-013), and Xuzhou Outstanding Medical Academic Leader Project and Xuzhou Science and Technology Grants (# XM13B066, XZZD1242).

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    Authors and Affiliations

    1. Xuzhou Medical College, Xuzhou, 221009, Jiangsu, China

      Qinqin Qiu & Yu Wang

    2. Department of Endocrinology, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical College, Affiliated Hospital of Southeast University, 199# South Jiefang Road, Xuzhou, 221009, Jiangsu, China

      Ying Gong, Xuekui Liu, Lianjun Dou, Yu Wang, Ben Wang & Jun Liang

    3. Xuzhou Institute of Medical Sciences, Xuzhou Institute of Diabetes, Xuzhou, 221009, Jiangsu, China

      Ying Gong, Xuekui Liu, Lianjun Dou, Yu Wang, Ben Wang & Jun Liang

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    1. Qinqin Qiu
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    Correspondence to Jun Liang.

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    Qinqin Qiu, Ying Gong and Jun Liang have contributed equally to this work.

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    Qiu, Q., Gong, Y., Liu, X. et al. Serum Uric Acid and Impaired Glucose Tolerance: The Cardiometabolic Risk in Chinese (CRC) Study. Cell Biochem Biophys 73, 155–162 (2015). https://doi.org/10.1007/s12013-015-0597-5

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