Skip to main content

Advertisement

SpringerLink
Log in

The Role of the rs1544410 Polymorphism of Vitamin D Receptor Gene in Breast Cancer Susceptibility

  • Original Paper
  • Published:
Cell Biochemistry and Biophysics Aims and scope Submit manuscript

Abstract

This study was devised to investigate the genetic effect modification of the BsmI polymorphism associated with the susceptibility to breast cancer. Case–control studies of the BsmI polymorphism and breast cancer were searched. A total of 17 eligible publications were included in our final analysis. Pooled ORs and 95 % CIs were obtained by means of fixed effects model. The general and stratified analyses according to ethnicity showed that the association between the BsmI polymorphism and the risk of breast cancer was not statistically significant. However, the subgroup of the hospital-based studies was found to confer protection against the disease (ORBBvs.bb = 0.83, 95 % CI = 0.71–0.97, P h = 0.571; ORBBvs.Bb+bb = 0.86, 95 % CI = 0.74–1.00, P h = 0.903; ORallele B vs. allele b = 0.92, 95 % CI = 0.86–0.99, P h = 0.337). Our results suggested that the presence of the BsmI polymorphism may contribute to the susceptibility of breast cancer. It is necessary that future large-scale studies should be conducted to further confirm the association between the BsmI polymorphism and breast cancer risk.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Darwish, H., & DeLuca, H. F. (1993). Vitamin D-regulated gene expression. Critical Reviews in Eukaryotic Gene Expression, 3(2), 89–116.

    CAS  PubMed  Google Scholar 

  2. Hannah, S. S., & Norman, A. W. (1994). 1 alpha,25(OH)2 vitamin D3-regulated expression of the eukaryotic genome. Nutrition Reviews, 52(11), 376–382.

    Article  CAS  PubMed  Google Scholar 

  3. Minghetti, P. P., & Norman, A. W. (1988). 1,25(OH)2-vitamin D3 receptors: gene regulation and genetic circuitry. FASEB Journal, 2(15), 3043–3053.

    CAS  PubMed  Google Scholar 

  4. Crew, K. D., et al. (2009). Association between plasma 25-hydroxyvitamin D and breast cancer risk. Cancer Prevention Research (Philadelphia, Pa.), 2(6), 598–604.

    Article  CAS  Google Scholar 

  5. Janowsky, E. C., et al. (1999). Association between low levels of 1,25-dihydroxyvitamin D and breast cancer risk. Public Health Nutrition, 2(3), 283–291.

    Article  CAS  PubMed  Google Scholar 

  6. Bertone-Johnson, E. R., et al. (2005). Plasma 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D and risk of breast cancer. Cancer Epidemiology Biomarkers and Prevention, 14(8), 1991–1997.

    Article  CAS  Google Scholar 

  7. Lappe, J. M., et al. (2007). Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial. American Journal of Clinical Nutrition, 85(6), 1586–1591.

    CAS  PubMed  Google Scholar 

  8. Deeb, K. K., Trump, D. L., & Johnson, C. S. (2007). Vitamin D signalling pathways in cancer: potential for anticancer therapeutics. Nature Reviews Cancer, 7(9), 684–700.

    Article  CAS  PubMed  Google Scholar 

  9. Krishnan, A. V., Swami, S., & Feldman, D. (2010). Vitamin D and breast cancer: inhibition of estrogen synthesis and signaling. Journal of Steroid Biochemistry and Molecular Biology, 121(1–2), 343–348.

    Article  CAS  PubMed  Google Scholar 

  10. Colston, K., & Colston, M. J. (2005). Vitamin D and breast cancer. In D. Feldman (Ed.), Vitamin D (pp. 1663–1677). Stanford (CA): Elsevier Academic Press.

    Chapter  Google Scholar 

  11. Lopes, N., et al. (2010). Alterations in Vitamin D signalling and metabolic pathways in breast cancer progression: a study of VDR, CYP27B1 and CYP24A1 expression in benign and malignant breast lesions. BMC Cancer, 10, 483.

    Article  PubMed Central  PubMed  Google Scholar 

  12. Engel, L. S., et al. (2012). Vitamin D receptor gene haplotypes and polymorphisms and risk of breast cancer: a nested case-control study. Cancer Epidemiology Biomarkers and Prevention, 21(10), 1856–1867.

    Article  CAS  Google Scholar 

  13. Ma, J., et al. (1998). Vitamin D receptor polymorphisms, circulating vitamin D metabolites, and risk of prostate cancer in United States physicians. Cancer Epidemiology Biomarkers and Prevention, 7(5), 385–390.

    CAS  Google Scholar 

  14. Dawson-Hughes, B., Harris, S. S., & Finneran, S. (1995). Calcium absorption on high and low calcium intakes in relation to vitamin D receptor genotype. Journal of Clinical Endocrinology and Metabolism, 80(12), 3657–3661.

    CAS  PubMed  Google Scholar 

  15. Lambrinoudaki, I., et al. (2011). BsmI vitamin D receptor’s polymorphism and bone mineral density in men and premenopausal women on long-term antiepileptic therapy. European Journal of Neurology, 18(1), 93–98.

    Article  CAS  PubMed  Google Scholar 

  16. Taylor, J. A., et al. (1996). Association of prostate cancer with vitamin D receptor gene polymorphism. Cancer Research, 56(18), 4108–4110.

    CAS  PubMed  Google Scholar 

  17. Ruggiero, M., et al. (1998). Vitamin D receptor gene polymorphism is associated with metastatic breast cancer. Oncology Research, 10(1), 43–46.

    CAS  PubMed  Google Scholar 

  18. Ingles, S. A., et al. (2000). Vitamin D receptor genotype and breast cancer in Latinas (United States). Cancer Causes and Control, 11(1), 25–30.

    Article  CAS  PubMed  Google Scholar 

  19. Hou, M. F., et al. (2002). Association of vitamin D receptor gene polymorphism with sporadic breast cancer in Taiwanese patients. Breast Cancer Research and Treatment, 74(1), 1–7.

    Article  CAS  PubMed  Google Scholar 

  20. Buyru, N., et al. (2003). Vitamin D receptor gene polymorphisms in breast cancer. Experimental and Molecular Medicine, 35(6), 550–555.

    Article  CAS  PubMed  Google Scholar 

  21. Guy, M., et al. (2004). Vitamin D receptor gene polymorphisms and breast cancer risk. Clinical Cancer Research, 10(16), 5472–5481.

    Article  CAS  PubMed  Google Scholar 

  22. Hefler, L. A., et al. (2004). Estrogen-metabolizing gene polymorphisms in the assessment of breast carcinoma risk and fibroadenoma risk in Caucasian women. Cancer, 101(2), 264–269.

    Article  CAS  PubMed  Google Scholar 

  23. Lowe, L. C., et al. (2005). Plasma 25-hydroxy vitamin D concentrations, vitamin D receptor genotype and breast cancer risk in a UK Caucasian population. European Journal of Cancer, 41(8), 1164–1169.

    Article  CAS  PubMed  Google Scholar 

  24. Chen, W. Y., et al. (2005). Associations between polymorphisms in the vitamin D receptor and breast cancer risk. Cancer Epidemiology Biomarkers and Prevention, 14(10), 2335–2339.

    Article  CAS  Google Scholar 

  25. Trabert, B., et al. (2007). Vitamin D receptor polymorphisms and breast cancer risk in a large population-based case-control study of Caucasian and African-American women. Breast Cancer Research, 9(6), R84.

    Article  PubMed Central  PubMed  Google Scholar 

  26. Sinotte, M., et al. (2008). Vitamin D receptor polymorphisms (FokI, BsmI) and breast cancer risk: association replication in two case-control studies within French Canadian population. Endocrine-Related Cancer, 15(4), 975–983.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  27. Gapska, P., et al. (2009). Vitamin D receptor variants and breast cancer risk in the Polish population. Breast Cancer Research and Treatment, 115(3), 629–633.

    Article  CAS  PubMed  Google Scholar 

  28. McKay, J. D., et al. (2009). Vitamin D receptor polymorphisms and breast cancer risk: results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium. Cancer Epidemiology Biomarkers and Prevention, 18(1), 297–305.

    Article  CAS  Google Scholar 

  29. Anderson, L. N., et al. (2011). Vitamin D-related genetic variants, interactions with vitamin D exposure, and breast cancer risk among Caucasian women in Ontario. Cancer Epidemiology Biomarkers and Prevention, 20(8), 1708–1717.

    Article  CAS  Google Scholar 

  30. Rollison, D. E., et al. (2012). Vitamin D intake, vitamin D receptor polymorphisms, and breast cancer risk among women living in the southwestern U.S. Breast Cancer Research and Treatment, 132(2), 683–691.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  31. Fuhrman, B. J., et al. (2013). Sunlight, polymorphisms of vitamin D-related genes and risk of breast cancer. Anticancer Research, 33(2), 543–551.

    CAS  PubMed Central  PubMed  Google Scholar 

  32. Mishra, D. K., et al. (2013). Vitamin D receptor gene polymorphisms and prognosis of breast cancer among African-American and Hispanic women. PLoS ONE, 8(3), e57967.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  33. Shahbazi, S., et al. (2013). BsmI but not FokI polymorphism of VDR gene is contributed in breast cancer. Medical Oncology, 30(1), 393.

    Article  PubMed  Google Scholar 

  34. Raimondi, S., et al. (2009). Review and meta-analysis on vitamin D receptor polymorphisms and cancer risk. Carcinogenesis, 30(7), 1170–1180.

    Article  CAS  PubMed  Google Scholar 

  35. Tang, C., et al. (2009). Fok1 polymorphism of vitamin D receptor gene contributes to breast cancer susceptibility: a meta-analysis. Breast Cancer Research and Treatment, 117(2), 391–399.

    Article  CAS  PubMed  Google Scholar 

  36. Mantel, N., & Haenszel, W. (1959). Statistical aspects of the analysis of data from retrospective studies of disease. Journal of the National Cancer Institute, 22(4), 719–748.

    CAS  PubMed  Google Scholar 

  37. DerSimonian, R., & Laird, N. (1986). Meta-analysis in clinical trials. Controlled Clinical Trials, 7(3), 177–188.

    Article  CAS  PubMed  Google Scholar 

  38. Egger, M., et al. (1997). Bias in meta-analysis detected by a simple, graphical test. BMJ, 315(7109), 629–634.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  39. Negri, E., et al. (1996). Intake of selected micronutrients and the risk of breast cancer. International Journal of Cancer, 65(2), 140–144.

    Article  CAS  Google Scholar 

  40. John, E. M., et al. (1999). Vitamin D and breast cancer risk: the NHANES I Epidemiologic follow-up study, 1971-1975 to 1992. National Health and Nutrition Examination Survey. Cancer Epidemiology Biomarkers and Prevention, 8(5), 399–406.

    CAS  Google Scholar 

  41. Shin, M. H., et al. (2002). Intake of dairy products, calcium, and vitamin d and risk of breast cancer. Journal of the National Cancer Institute, 94(17), 1301–1311.

    Article  CAS  PubMed  Google Scholar 

  42. Banerjee, P., & Chatterjee, M. (2003). Antiproliferative role of vitamin D and its analogs–a brief overview. Molecular and Cellular Biochemistry, 253(1–2), 247–254.

    Article  CAS  PubMed  Google Scholar 

  43. Welsh, J. (2004). Vitamin D and breast cancer: insights from animal models. American Journal of Clinical Nutrition, 80(6 Suppl), 1721S–1724S.

    CAS  PubMed  Google Scholar 

  44. Eisman, J. A., et al. (1979). 1,25-dihydroxyvitamin-D-receptor in breast cancer cells. Lancet, 2(8156–8157), 1335–1336.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Oncology, The First Affiliated Hospital of Xinxiang, Medical University, Xinxiang, China

    Xiaorui Li, Xiaoqing Huo, Weiwei Li, Qinghui Yang, Ying Wang & Xiaochun Kang

Authors
  1. Xiaorui Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Xiaoqing Huo
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Weiwei Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Qinghui Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Ying Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Xiaochun Kang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Xiaorui Li.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Li, X., Huo, X., Li, W. et al. The Role of the rs1544410 Polymorphism of Vitamin D Receptor Gene in Breast Cancer Susceptibility. Cell Biochem Biophys 70, 1951–1956 (2014). https://doi.org/10.1007/s12013-014-0155-6

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12013-014-0155-6

Keywords

Search

Navigation