Skip to main content

Advertisement

SpringerLink
Log in

RETRACTED ARTICLE: Ergosterol Attenuates Isoproterenol-Induced Myocardial Cardiotoxicity

  • Published:
Cardiovascular Toxicology Aims and scope Submit manuscript

This article was retracted on 25 May 2023

This article has been updated

Abstract

Phytomedicine has shown a promising potential for the prevention of cardiovascular system diseases and disorders. This study aimed to evaluate protective effect of ergosterol (ER) on isoproterenol (ISO)-induced myocardial cardiotoxicity. We found that pretreatment with ER significantly decreased levels of myocardial CK-MB and LDH, and alleviated myocardial damage induced by ISO in rat model. In addition, ER restored Nrf2 and HO-1 expression and inhibited apoptosis through upregulating Bcl-2 and downregulating Bax, cytochrome c, cleaved caspase-3, caspase-9, and PARP in rat hearts. Hypoxia-reoxygenation model in H9C2 cells confirmed the cardioprotective effects of ER. In conclusion, we provide both in vitro and in vivo evidence that ER significantly enhances Nrf2-mediated anti-oxidative activities, and exerts a protective effect on cardiomyocyte apoptosis. ER could be considered as a potential therapeutic agent to prevent myocardial injury.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

Similar content being viewed by others

Change history

References

  1. Thygesen, K., Alpert, J. S., Jaffe, A. S., Chaitman, B. R., Bax, J. J., Morrow, D. A., et al. (2018). Fourth universal definition of myocardial infarction (2018). Journal of the American College of Cardiology, 72, 2231–2264.

    Article  PubMed  Google Scholar 

  2. Adameova, A. D., Bhullar, S. K., Elimban, V., & Dhalla, N. S. (2018). Activation of β1-adrenoceptors may not be involved in arrhythmogenesis in ischemic heart disease. Reviews in Cardiovascular Medicine, 19, 97–101.

    PubMed  Google Scholar 

  3. Neri, M., Fineschi, V., Di Paolo, M., Pomara, C., Riezzo, I., Turillazzi, E., et al. (2015). Cardiac oxidative stress and inflammatory cytokines response after myocardial infarction. Current Vascular Pharmacology, 13, 26–36.

    Article  CAS  PubMed  Google Scholar 

  4. Caccioppo, A., Franchin, L., Grosso, A., Angelini, F., D'Ascenzo, F., & Brizzi, M. F. (2019). Ischemia reperfusion injury: Mechanisms of damage/protection and novel strategies for cardiac recovery/regeneration. International Journal of Molecular Sciences, 20, 5024.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Neri, M., Riezzo, I., Pascale, N., Pomara, C., & Turillazzi, E. (2017). Ischemia/reperfusion injury following acute myocardial infarction: a critical issue for clinicians and forensic pathologists. Mediators of Inflammation, 2017, 7018393.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Radhiga, T., Rajamanickam, C., Sundaresan, A., Ezhumalai, M., & Pugalendi, K. V. (2012). Effect of ursolic acid treatment on apoptosis and DNA damage in isoproterenol-induced myocardial infarction. Biochimie, 94, 1135–1142.

    Article  CAS  PubMed  Google Scholar 

  7. Hwa, J. S., Jin, Y. C., Lee, Y. S., Ko, Y. S., Kim, Y. M., Shi, L. Y., et al. (2012). 2-Methoxycinnamaldehyde from Cinnamomum cassia reduces rat myocardial ischemia and reperfusion injury in vivo due to HO-1 induction. Journal of Ethnopharmacology, 139, 605–615.

    Article  CAS  PubMed  Google Scholar 

  8. Hao, E., Lang, F., Chen, Y., Zhang, H., Cong, X., Shen, X., et al. (2013). Resveratrol alleviates endotoxin-induced myocardial toxicity via the Nrf2 transcription factor. PLoS ONE, 8, e69452.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Wei, B., Li, W. W., Ji, J., Hu, Q. H., & Ji, H. (2014). The cardioprotective effect of sodium tanshinone IIA sulfonate and the optimizing of therapeutic time window in myocardial ischemia/reperfusion injury in rats. Atherosclerosis, 235, 318–327.

    Article  CAS  PubMed  Google Scholar 

  10. Lee, T.-M., Lin, S.-Z., & Chang, N.-C. (2014). Antiarrhythmic effect of lithium in rats after myocardial infarction by activation of Nrf2/HO-1 signaling. Free Radical Biology & Medicine, 77, 71–81.

    Article  CAS  Google Scholar 

  11. Montes, F. Q., Vázquez-Hernández, A., & Fenton-Navarro, B. (2019). Active compounds of medicinal plants, mechanism for antioxidant and beneficial effects. Phyton-International Journal of Experimental Botany, 88, 1–10.

    Google Scholar 

  12. Villa-Hernández, J. M., García-Ocón, B., Sierra-Palacios, E. C., & Pelayo-Zaldivar, C. (2018). Molecular biology techniques as new alternatives for medicinal plant identification. Phyton-International Journal of Experimental Botany, 87, 72–78.

    Google Scholar 

  13. Huan, W., Tianzhu, Z., Yu, L., & Shumin, W. (2017). Effects of ergosterol on COPD in mice via JAK3/STAT3/NF-κB pathway. Inflammation, 40(3), 884–893.

    Article  PubMed  Google Scholar 

  14. Kaplan, A., Yabluchanskiy, A., Ghali, R., Altara, R., Booz, G. W., & Zouein, F. A. (2018). Cerebral blood flow alteration following acute myocardial infarction in mice. Bioscience Report, 38(5), 20180382.

    Article  Google Scholar 

  15. Fu, L., Liu, Y., Wang, J., Sun, Y., Zhang, L., Wu, T., et al. (2017). Cardioprotection by low-dose of estrogen and testosterone at the physiological ratio on ovariectomized rats during ischemia/reperfusion injury. Journal of Cardiovascular Pharmacology, 70(2), 87–93.

    Article  CAS  PubMed  Google Scholar 

  16. Zhou, C., Busso, C. A., Yang, Y. G., Zhang, Z., Wang, Z. W., Yang, Y. F., et al. (2017). Effect of mixed salt stress on malondialdehyde, proteins and antioxidant enzymes of Leymus chinensis in three leaf colors. Phyton-International Journal of Experimental Botany, 86, 205–213.

    Google Scholar 

  17. Bellezza, I. (2018). Oxidative stress in age-related macular degeneration: Nrf2 as therapeutic target. Frontier in Pharmacology, 9, 1280.

    Article  CAS  Google Scholar 

  18. Gottlieb, R. A., Burleson, K. O., Kloner, R. A., Babior, B. M., & Engler, R. L. (1994). Reperfusion injury induces apoptosis in rabbit cardiomyocytes. J Clin Invest, 94, 1621–1628.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Frangogiannis, N. G. (2015). Pathophysiology of myocardial infarction. Comprehensive Physiology, 5(4), 1841–1875.

    Article  PubMed  Google Scholar 

  20. Turillazzi, E., Cerretani, D., Cantatore, S., Fiaschi, A. I., Frati, P., Micheli, L., et al. (2017). Myocardial oxidative damage is induced by cardiac Fas-dependent and mitochondria-dependent apoptotic pathways in human cocaine-related overdose. Scientific Reports, 7, 44262.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Wu, Y., Dai, W. D., & Fu, Q. S. (2018). Increased apoptosis of trophoblasts from pregnancies complicated by intrauterine growth restriction is associated with aberrant Fas-associated death domain (FADD) expression. Clinical and Experimental Obstetrics and Gynecology, 45, 747–751.

    Article  Google Scholar 

Download references

Funding

This study was supported in part by the National Natural Science Foundation of China (81700346) and the Natural Foundation of Jiangsu Province (BK20160549).

Author information

Authors and Affiliations

  1. Xiamen Cardiovascular Hospital, Xiamen University, Xiamen, 361004, China

    Qifei Xie, Suiji Li, Cuilian Dai & Juan Song

  2. Department of Pathology, The Affiliated Kunshan Hospital of Jiangsu University, The First People’s Hospital of Kunshan, Suzhou, 215300, China

    Yun Gao & Ling Jin

Authors
  1. Qifei Xie
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Suiji Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yun Gao
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ling Jin
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Cuilian Dai
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Juan Song
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

QX, SL, YG, LJ, and CD performed in vivo and in vitro experiments and collected the data; JS designed the study and wrote the manuscript.

Corresponding authors

Correspondence to Cuilian Dai or Juan Song.

Ethics declarations

Conflicts of interest

The authors declare no conflicts of interest.

Additional information

Handling Editor: Y. James Kang.

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This article has been retracted. Please see the retraction notice for more detail: https://doi.org/10.1007/s12012-023-09796-4

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Xie, Q., Li, S., Gao, Y. et al. RETRACTED ARTICLE: Ergosterol Attenuates Isoproterenol-Induced Myocardial Cardiotoxicity. Cardiovasc Toxicol 20, 500–506 (2020). https://doi.org/10.1007/s12012-020-09574-6

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12012-020-09574-6

Keywords

Search

Navigation