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Catechin Attenuates Coronary Heart Disease in a Rat Model by Inhibiting Inflammation

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Abstract

Accumulating evidence has established that systemic inflammation is an important pathophysiologic factor of coronary heart disease (CHD). In this study, we investigated whether catechin exerts anti-inflammatory function in CHD rats. CHD model of rats was established by high-fat diet feeding and pituitrin injection. The successful building of CHD model was confirmed using blood liquid biochemical analyzer. Additionally, the effects of catechin on CHD parameters and several inflammatory signaling were investigated. The levels of total cholesterol, high-density lipoprotein, low-density lipoprotein cholesterin, triglyceride and blood glucose were all significantly elevated in CHD rats compared to them in control rats, suggesting the successful establishment of CHD model. Administration of catechin attenuated CHD by reversing the levels of creatine kinase, creatine kinase-MB, lactate dehydrogenase, cardiac troponin (cTnT), ventricular ejection fraction (LVEF) and systolic internal diameter (LVIDs). Additionally, several inflammatory biomarkers or cytokines such as C-reactive protein, lipoprotein-associated phospholipase A2 (Lp-PLA2), interleukin (IL)-6 and tumor necrosis factor-alpha (TNF-α) were inhibited by catechin. In contrast to nuclear factor-kappa beta (NF-κB), several proteins involved in inflammation such as farnesoid X receptor, signal transducers and activators of transcription (STAT)-3 and protein kinase B (PKB/Akt) were all activated by catechin. Catechin could be used as a promising treatment for CHD based on its role in suppressing inflammation and balancing STAT-3 signaling.

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Funding

This study was supported by The Science and Technology Development Funding of Nanjing Medical University (Key Projects).

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Authors and Affiliations

  1. Department of Emergency, Wuxi Second People’s Hospital Affiliated to Nanjing Medical University, 68 Zhongshan Road, Wuxi, 214002, Jiangsu, China

    Su Tu & Xiaochun Fan

  2. Department of Cardiology, Wuxi People’s Hospital Affiliated to Nanjing Medical University, 299 Qingyang Road, Wuxi, 214023, Jiangsu, China

    Feng Xiao

  3. Department of Geriatric Cardiology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, Jiangsu, China

    Xiaoyan Min

  4. Department of Cardiology, Taizhou Second People’s Hospital, 27 Jiankang Road, Taizhou, 225500, Jiangsu, China

    Huiping Chen

  5. Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, Jiangsu, China

    Kejiang Cao

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  1. Su Tu
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  2. Feng Xiao
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  3. Xiaoyan Min
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  4. Huiping Chen
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Correspondence to Kejiang Cao.

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The authors declare that they have no conflict of interest.

Research Involving Human Participants and/or Animals

All applicable international, national and/or institutional guidelines for the care and use of animals were followed.

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Tu, S., Xiao, F., Min, X. et al. Catechin Attenuates Coronary Heart Disease in a Rat Model by Inhibiting Inflammation. Cardiovasc Toxicol 18, 393–399 (2018). https://doi.org/10.1007/s12012-018-9449-z

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  • DOI: https://doi.org/10.1007/s12012-018-9449-z

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