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Safety Evaluation of Sevoflurane as Anesthetic Agent in Mouse Model of Myocardial Ischemic Infarction

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Abstract

The selection of anesthetics for patients with myocardial infarction is critically challenging. Sevoflurane is a volatile anesthetic gradually used in recent years. The intraoperative hemodynamic stability of sevoflurane was supported by several studies with some suggestions for its use for patients with cardiac events. The present study was undertaken to investigate the effect of sevoflurane on mice with myocardial infarction to evaluate the safety issue of this agent for possible application in patients with myocardial infarction. Mice of 7–12 weeks old were subjected to left anterior descending artery ligation to introduce acute myocardial infarction. The effect of sevoflurane on the hemodynamics was examined in comparison with that of currently available agent etomidate at low and moderate doses. The results showed that sevoflurane caused unstable hemodynamic changes in mice with myocardial infarction at both low and moderate inhaled concentrations relative to low and moderate doses of etomidate. In addition, the relative safety margin estimated from therapeutic index was decreased by 50 % when sevoflurane was used for mice with myocardial infarction relative to control mice, but only decreased by 20 % for etomidate. These analyses indicate that in comparison with currently available agent etomidate, sevoflurane should not be applied to patients with myocardial infarction or other cardiac events.

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    Authors and Affiliations

    1. Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China

      Xiang Cheng, Jiaming Liu, Xiaorong Sun, Qin Sheng, Pengfei Han & Y. James Kang

    2. Department of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China

      Jianglong Hou

    3. Department of Anesthesiology and Pain Medicine, Affiliated Haikou Hospital of Xiangya Medical School, Central South University, Haikou, 570100, Hainan, China

      Xiang Cheng

    Authors
    1. Xiang Cheng
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    2. Jianglong Hou
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    3. Jiaming Liu
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    4. Xiaorong Sun
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    6. Pengfei Han
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    7. Y. James Kang
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    Correspondence to Y. James Kang.

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    Xiang Cheng and Jianglong Hou have contributed equally to this work.

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    Cheng, X., Hou, J., Liu, J. et al. Safety Evaluation of Sevoflurane as Anesthetic Agent in Mouse Model of Myocardial Ischemic Infarction. Cardiovasc Toxicol 17, 150–156 (2017). https://doi.org/10.1007/s12012-016-9368-9

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    • DOI: https://doi.org/10.1007/s12012-016-9368-9

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