Abstract
The aim of the study was to determine the relationship between exposure to cigarette smoke and the morphology of atherosclerotic plaques in the extracranial arteries assessed by computed tomography angiography in patients with hypertension. The study included 61 hypertensive patients: 17 active smokers (group A), 18 non-smokers, declaring environmental exposure to tobacco smoke (group B), and 26 non-smokers, not declaring exposure to cigarette smoke (group C). The number of segments with plaques was significantly higher in group A compared to groups B and C. The number of segments with non-calcified and mixed plaques was significantly higher in group A and group B than in group C. A positive correlation between cigarette-years and the number of segments with atherosclerotic plaques was noted. In summary, both active smoking and environmental exposure to tobacco smoke appear to increase the number of segments of the extracranial arteries with non-calcified and mixed atherosclerotic plaques.
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Centers for Disease Control and Prevention (US), National Center for Chronic Disease Prevention and Health Promotion (US), Office on Smoking and Health (US) (2010). How tobacco smoke causes disease: The biology and behavioral basis for smoking-attributable disease: A report of the Surgeon General. Centers for Disease Control and Prevention (US), Atlanta.
Mainali, P., Pant, S., Rodriguez, A. P., Deshmukh, A., & Mehta, J. L. (2015). Tobacco and cardiovascular health. Cardiovascular Toxicology, 15, 107–116.
Perk, J., De Backer, G., Gohlke, H., Graham, I., Reiner, Z., Verschuren, W. M., et al. (2012). European Guidelines on cardiovascular disease prevention in clinical practice (version 2012): The Fifth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of nine societies and by invited experts). Atherosclerosis, 223, 1–68.
Gać, P., Poręba, R., Poręba, M., Mazur, G., & Sobieszczańska, M. (2014). Effect of environmental exposure to cigarette smoke on blood pressure in 24-hour ambulatory blood pressure monitoring in patients with essential hypertension. Polskie Archiwum Medycyny Wewnetrznej, 124, 436–442.
Gać, P., & Sobieszczańska, M. (2014). Effects of cigarette smoke on Holter ECG recordings in patients with arterial hypertension. Part 1: Time domain parameters of heart rate variability. Environmental Toxicology and Pharmacology, 37, 404–413.
Gać, P., & Sobieszczańska, M. (2014). Effects of cigarette smoke on Holter ECG recordings in patients with arterial hypertension. Part 2: Parameters of heart rate turbulence. Environmental Toxicology and Pharmacology, 37, 600–607.
Ibrahimi, P., Jashari, F., Nicoll, R., Bajraktari, G., Wester, P., & Henein, M. Y. (2013). Coronary and carotid atherosclerosis: How useful is the imaging? Atherosclerosis, 231, 323–333.
Naylor, A. R. (2014). Identifying the high-risk carotid plaque. Journal of Cardiovascular Surgery (Torino), 55(2 Suppl 1), 11–20.
DeMarco, J. K., & Huston, J, 3rd. (2014). Imaging of high-risk carotid artery plaques: Current status and future directions. Neurosurgical Focus, 36, E1.
Lell, M., Fellner, C., Baum, U., Hothorn, T., Steiner, R., Lang, W., et al. (2007). Evaluation of carotid artery stenosis with multisection CT and MR imaging: influence of imaging modality and postprocessing. AJNR. American Journal of Neuroradiology, 28, 104–110.
Achenbach, S., Ropers, D., Kuettner, A., Flohr, T., Ohnesorge, B., Bruder, H., et al. (2006). Contrast-enhanced coronary artery visualization by dual-source computed tomography—Initial experience. European Journal of Radiology, 57, 331–335.
North American Symptomatic Carotid Endarterectomy Trial Collaborators. (1991). Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis. New England Journal of Medicine, 325, 445–453.
Ballotta, E., Da Giau, G., & Renon, L. (2000). Carotid plaque gross morphology and clinical presentation: A prospective study of 457 carotid artery specimens. Journal of Surgical Research, 89, 78–84.
Kweon, S. S., Lee, Y. H., Shin, M. H., Choi, J. S., Rhee, J. A., Choi, S. W., et al. (2012). Effects of cumulative smoking exposure and duration of smoking cessation on carotid artery structure. Circulation Journal, 76, 2041–2047.
Jiang, C. Q., Xu, L., Lam, T. H., Lin, J. M., Cheng, K. K., & Thomas, G. N. (2010). Smoking cessation and carotid atherosclerosis: The Guangzhou Biobank Cohort Study—CVD. Journal of Epidemiology and Community Health, 64, 1004–1009.
Yerly, P., Rodondi, N., Viswanathan, B., Riesen, W., Vogt, P., & Bovet, P. (2013). Association between conventional risk factors and different ultrasound-based markers of atherosclerosis at carotid and femoral levels in a middle-aged population. International Journal of Cardiovascular Imaging, 29, 589–599.
Cardoso, C. R., Marques, C. E., Leite, N. C., & Salles, G. F. (2012). Factors associated with carotid intima-media thickness and carotid plaques in type 2 diabetic patients. Journal of Hypertension, 30, 940–947.
Kaźmierski, R., Michalak, S., & Kozubski, W. (2011). Ultrasound-based markers of carotid atherosclerosis correlate well with the number of classical atherosclerotic risk factors. Neurologia i Neurochirurgia Polska, 45, 317–327.
Herder, M., Johnsen, S. H., Arntzen, K. A., & Mathiesen, E. B. (2012). Risk factors for progression of carotid intima-media thickness and total plaque area: a 13-year follow-up study: The Tromsø Study. Stroke, 43, 1818–1823.
Vukadinovic, D., Rozie, S., van Gils, M., van Walsum, T., Manniesing, R., van der Lugt, A., & Niessen, W. J. (2012). Automated versus manual segmentation of atherosclerotic carotid plaque volume and components in CTA: Associations with cardiovascular risk factors. International Journal of Cardiovascular Imaging, 28, 877–887.
Johnson, H. M., Piper, M. E., Jorenby, D. E., Fiore, M. C., Baker, T. B., & Stein, J. H. (2010). Risk factors for subclinical carotid atherosclerosis among current smokers. Preventive Cardiology, 13, 166–171.
Gall, S., Huynh, Q. L., Magnussen, C. G., Juonala, M., Viikari, J. S., Kähönen, M., et al. (2014). Exposure to parental smoking in childhood or adolescence is associated with increased carotid intima-media thickness in young adults: Evidence from the Cardiovascular Risk in Young Finns study and the Childhood Determinants of Adult Health Study. European Heart Journal, 35, 2484–2491.
Yang, B., Li, M., Chen, B., Xu, Y., & Li, T. D. (2012). Deterioration of endothelial function and carotid intima-media thickness in Tibetan male adolescents exposed to second-hand smoke. Journal of Renin-Angiotensin-Aldosterone System, 13, 413–419.
Kallio, K., Jokinen, E., Saarinen, M., Hämäläinen, M., Volanen, I., Kaitosaari, T., et al. (2010). Arterial intima-media thickness, endothelial and apolipoproteins in adolescents frequently exposed to tobacco smoke. Circulation: Cardiovascular Quality and Outcomes, 3, 196–203.
Mack, W. J., Islam, T., Lee, Z., Selzer, R. H., & Hodis, H. N. (2003). Environmental tobacco smoke and carotid arterial stiffness. Preventive Medicine, 37, 148–154.
Redgrave, J. N., Lovett, J. K., & Rothwell, P. M. (2010). Histological features of symptomatic carotid plaques in relation to age and smoking: The oxford plaque study. Stroke, 41, 2288–2294.
van den Bouwhuijsen, Q. J., Vernooij, M. W., Hofman, A., Krestin, G. P., van der Lugt, A., & Witteman, J. C. (2012). Determinants of magnetic resonance imaging detected carotid plaque components: The Rotterdam Study. European Heart Journal, 33, 221–229.
Zanchetti, A., Bond, M. G., Hennig, M., Neiss, A., Mancia, G., Dal Palù, C., et al. (2002). Calcium antagonist lacidipine slows down progression of asymptomatic carotid atherosclerosis: principal results of the European Lacidipine Study on Atherosclerosis (ELSA), a randomized, double-blind, long-term trial. Circulation, 106, 2422–2427.
Hirohata, A., Yamamoto, K., Miyoshi, T., Hatanaka, K., Hirohata, S., Yamawaki, H., et al. (2010). Impact of olmesartan on progression of coronary atherosclerosis a serial volumetric intravascular ultrasound analysis from the OLIVUS (impact of Olmesarten on progression of coronary atherosclerosis: Evaluation by intravascular ultrasound) trial. Journal of the American College of Cardiology, 55, 976–982.
Sipahi, I., Tuzcu, E. M., Wolski, K. E., Nicholls, S. J., Schoenhagen, P., Hu, B., et al. (2007). Beta-blockers and progression of coronary atherosclerosis: pooled analysis of 4 intravascular ultrasonography trials. Annals of Internal Medicine, 147, 10–18.
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Gać, P., Jaźwiec, P., Mazur, G. et al. Exposure to Cigarette Smoke and the Morphology of Atherosclerotic Plaques in the Extracranial Arteries Assessed by Computed Tomography Angiography in Patients with Essential Hypertension. Cardiovasc Toxicol 17, 67–78 (2017). https://doi.org/10.1007/s12012-015-9357-4
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DOI: https://doi.org/10.1007/s12012-015-9357-4