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Association Between Whole Blood Selenium Levels and Triglyceride-to-High-Density Lipoprotein Cholesterol Ratio Among the General Population

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Abstract

Our study aimed to examine whether whole blood selenium (WBSe) levels are related to the triglyceride-to-high-density lipoprotein cholesterol (TG/HDL-C) ratio among the general population. A total of 13,470 adults were included and analyzed from the National Health and Nutrition Examination Survey (NHANES) 2011–2018. In multivariable analyses, LnWBSe levels were significantly related to Ln(TG/HDL-C) ratio in fully adjusted model (β = 0.35; 95% confidence interval (CI): 0.22, 0.48; P < 0.001). Furthermore, the highest quartile of LnWBSe levels was positively correlated with Ln(TG/HDL-C) ratio compared with the lowest quartile (β = 0.15; 95% CI: 0.10, 0.20; P for trend < 0.001). In the dose–response analyses, the correlation was non-linear. While LnWBSe levels < 1.10, LnWBSe levels were positively related to Ln(TG/HDL-C) ratio (β = 0.41; 95% CI: 0.31, 0.50; P < 0.001), whereas LnWBSe levels ≥ 1.10, the relationship was not significantly (β =  − 0.20; 95% CI: − 0.54, 0.13; P = 0.228). The interaction test was significant for age, sex, total cholesterol (TC), and diastolic blood pressure (DBP) (all P for interaction < 0.05). Overall, WBSe levels were positively related to TG/HDL-C ratio, with a non-linear trend. Further research is required to determine these underlying mechanisms.

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Data Availability

The data is freely available from the NHANES.

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Acknowledgements

We thank the NHANES for their efforts.

Funding

This work was supported by grants from the National Natural Science Foundation of China (82000411, 82030051), the National Key R&D Program of China (2021YFF0501403), and the Key R&D Program of Shandong Province (ZR2020QH023, 2021SFGC0503, 2021ZDSYS05, and 2020ZLYS05).

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Authors and Affiliations

  1. National Key Laboratory for Innovation and Transformation of Luobing Theory, The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, Department of Cardiology, Qilu Hospital of Shandong University, Jinan, China

    Kunsheng Zhao, Yun Zhang & Wenhai Sui

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KZ collected the data and drafted the manuscript. YZ and WS conceived the study and edited and reviewed the manuscript. All the authors have read the manuscript and approved the submitted version.

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Correspondence to Yun Zhang or Wenhai Sui.

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Zhao, K., Zhang, Y. & Sui, W. Association Between Whole Blood Selenium Levels and Triglyceride-to-High-Density Lipoprotein Cholesterol Ratio Among the General Population. Biol Trace Elem Res 202, 1998–2007 (2024). https://doi.org/10.1007/s12011-023-03839-1

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