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Association of Serum Selenium and Selenoprotein P with Oxidative Stress Biomarkers in Patients with Polycystic Ovary Syndrome

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Abstract

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age which is characterized by various reproductive and metabolic disorders. Oxidative stress (OS) is now recognized to be involved in the pathogenesis of PCOS which could be targeted in the management of PCOS-related complications. Selenium (Se), as an antioxidant trace element, has been shown to decrease in PCOS patients. This study aimed to investigate the relationship between the Se and selenoprotein P (SELENOP) levels with OS markers in women with PCOS. In this cross-sectional study, 125 females aged 18–45 years diagnosed with PCOS were included. Demographic, clinical, and lifestyle information of participants were obtained using the relevant questionnaires. Fasting blood samples were collected to measure biochemical parameters. Serum levels of thiobarbituric acid reactive substances (TBARS), total antioxidant capacity (TAC), erythrocyte superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase activities as well as anthropometric measurements were assessed across tertiles of serum concentrations of Se and SELENOP. Higher serum levels of Se were associated with higher serum TAC levels (β=0.42, P<0.001) and erythrocytes GPx activity (β=0.28, P=0.002) as well as with lower serum TBARS levels (β= −0.26, P=0.003). Similarly, higher serum levels of SELENOP were associated with higher TAC (β=0.32, P<0.001) and erythrocyte GPx activity (β=0.30, P=0.001). SELENOP also showed an inverse association with serum levels of TBARS (β= −0.40, P<0.001). Nevertheless, erythrocytes SOD and CAT activities showed no significant relationships with serum Se and SELENOP concentrations (all P>0.05). The present study found that serum Se and SELENOP levels were inversely associated with TBARS levels and positively associated with TAC levels and erythrocytes GPx activity.

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Data Availability

The data that support the findings of this study are available from the corresponding author upon reasonable request.

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Acknowledgements

The authors appreciate the vice-chancellor of research and nutrition research center of Zabol University of Medical Sciences for their financial support. The researchers also appreciate all patients that participated in this study.

Funding

This work was supported by the Zabol University of Medical Sciences.

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Authors and Affiliations

  1. Department of Nutrition, Faculty of Public Health, Zabol University of Medical Sciences, Zabol, Iran

    Farshad Amirkhizi

  2. Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran

    Mahdiyeh Taghizadeh, Banafshe Khalese-Ranjbar & Somayyeh Asghari

  3. Department of Epidemiology and Biostatistics, Faculty of Public Health, Zabol University of Medical Sciences, Zabol, Iran

    Soudabeh Hamedi-Shahraki

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  1. Farshad Amirkhizi
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Contributions

Farshad Amirkhizi and Somayyeh Asghari contributed to the study conception and design. Material preparation, data collection, and analysis were performed by Soudabeh Hamedi-Shahraki and Farshad Amirkhizi. The first draft of the manuscript was written by Mahdiyeh Taghizadeh and Banafshe Khalese-Ranjbar. Somayyeh Asghari commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Somayyeh Asghari.

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Ethics Approval

The study protocol was approved by the ethics committee of Zabol University of Medical Sciences (ethics code: IR.ZBMU.REC.1399.084) and conducted according to the guidelines of the Declaration of Helsinki.

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Informed consent was obtained from all participants prior to the study enrollment.

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Amirkhizi, F., Taghizadeh, M., Khalese-Ranjbar, B. et al. Association of Serum Selenium and Selenoprotein P with Oxidative Stress Biomarkers in Patients with Polycystic Ovary Syndrome. Biol Trace Elem Res 202, 947–954 (2024). https://doi.org/10.1007/s12011-023-03747-4

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