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Association Between Parameters of Cortisol Metabolism, Biomarkers of Minerals (Zinc, Selenium, and Magnesium), and Insulin Resistance and Oxidative Stress in Women with Obesity

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Abstract

This is a cross-sectional study with women divided into a group of those with obesity (n = 80) and a control group (n = 94). Statistical analysis was conducted using the SPSS program. There were high values of GPx and TBARS and reduced values of SOD in women with obesity compared to the control group. Obese women showed increased concentrations of cortisol in serum and urine as well as hypozincemia, hyposelenemia, and hypomagnesemia and increased urinary excretion of these minerals. There was a negative correlation between the cortisol/cortisone ratio and erythrocyte zinc and selenium concentrations and a significant positive correlation between GPx and SOD activity and erythrocyte and plasma concentrations of zinc and selenium. The results of the study suggest the influence of adiposity on the increase in cortisol concentrations and the role of this hormone in the compartmentalization of the minerals zinc, selenium, and magnesium. However, the association study does not allow identifying the impact of such action on the antioxidant defense system and insulin sensitivity.

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Data Availability

The dataset that support the results and findings of this research are available from the corresponding author upon request.

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Authors and Affiliations

  1. Department of Nutrition, Federal University of Piaui, Teresina, Brazil

    Jennifer Beatriz Silva Morais, Kyria Jayanne Climaco Cruz, Ana Raquel Soares de Oliveira, Bruna Emanuele Pereira Cardoso, Thaline Milany da Silva Dias, Stéfany Rodrigues de Sousa Melo, Loanne Rocha dos Santos, Juliana Soares Severo & Dilina do Nascimento Marreiro

  2. Federal University of Pará, Belém, Brazil

    Suelem Torres de Freitas

  3. School of Nursing, Federal University, Minas Gerais, Belo Horizonte, Brazil

    Gilberto Simeone Henriques

  4. Institute of Biomedical Sciences Abel Salazar, Center for Drug Discovery and Innovative Medicines, Laboratory of Physiology, Department of Immuno-Physiology and Pharmacology, University of Porto, Porto, Portugal

    Moisés Tolentino Bento da Silva

  5. Clinical Laboratory, Teresina, Piauí, Brazil

    Francisco Erasmo Oliveira

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Contributions

Morais J.B.S., Cruz K.J.C., Oliveira A.R.S., Santos L.R., Melo S.R.S., Severo J.S., Cardoso B.E., and Dias T.M. have participated in the redaction and the review of the manuscript; Morais J.B.S., Oliveira A.R.S., Cruz K.J.C., Santos L.R., Melo S.R.S., Oliveira F.E., and Freitas S.T. have participated in generation, collection, assembly, analysis, and/or interpretation of data; Silva M.T. and Henriques G.S. performed analysis and/or interpretation of data; Morais J.B.S. and Marreiro D.N. had supervised the paper and participated in the redaction and the review of the paper.

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Correspondence to Dilina do Nascimento Marreiro.

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Morais, J.B.S., Cruz, K.J.C., de Oliveira, A.R.S. et al. Association Between Parameters of Cortisol Metabolism, Biomarkers of Minerals (Zinc, Selenium, and Magnesium), and Insulin Resistance and Oxidative Stress in Women with Obesity. Biol Trace Elem Res 201, 5677–5691 (2023). https://doi.org/10.1007/s12011-023-03639-7

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