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The Serum Oxidative Stress Biomarkers and Selenium Levels in a Group of Migraine Patients Compared with Healthy Controls: a Case–Control Study

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A Correction to this article was published on 19 April 2022

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Abstract

Migraine is one of the most common neurological disorders associated with recurrent attacks of moderate to severe headache. Oxidative stress may play an important role in migraine pathogenesis. This study aimed to measure and compare the serum levels of Selenium, total antioxidant capacity (TAC), and malondialdehyde) MDA (in migraine patients and healthy individuals. This case–control study was performed on 31 migraine patients and 30 age and gender-matched healthy controls. The severity of headache was assessed with a standard questionnaire, and the serum levels of Selenium (Se), MDA, and TAC were measured via biochemical methods. The odds of migraine were calculated across quartile of Se and oxidative stress biomarkers via binary logistic regression. Migraine patients had a significant lower Se levels (81.06 ± 8.66 vs. 88.94 ± 10.23 μg/L, P = 0.002) and a significant higher MDA levels (3.04 ± 1.74 vs. 2.06 ± 0.59 nmol/ml, P = 0.005) compared to healthy participants. Although serum TAC levels (1.34 ± 0.34 vs.1.37 ± 0.33 mmol/L, P = 0.755) were not significantly different between migraine patients rather than healthy subjects. Individuals in the lowest quartile of Se levels were about eleven times more likely to have migraine than those in the highest quartile (OR: 11.2; 95%CI: 1.57 to 80.2; P-trend: 0.016). Besides, being in the highest quartile of the serum MDA level, the odds of having migraine increases 15.4 times compared to the lowest quartile (OR = 15.4, 95%CI: 1.1 to 221, P = 0.044). No significant association was found between TAC and migraine. The lower Se and MDA levels in migraine patients gives rise to the probability which oxidant status may play an underlying role in migraine pathophysiology.

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Data availability

The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Acknowledgements

We especially thank Dr. Ghasem Mosayebi and Dr. Amir Almasi-Hashiani. We also appreciate the migraine patients, healthy volunteers and all executive agents of this project.

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Authors and Affiliations

  1. Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran

    Afsoon Talaie & Hanieh Jafary

  2. Department of Neurology, School of Medicine, Arak University of Medical Sciences, Arak, Iran

    Fardin Faraji

  3. Traditional and Complementary Medicine Research Center (TCMRC), Arak University of Medical Sciences, Arak, Iran

    Fardin Faraji

  4. Applied Neuroscience Research Center, Islamic Azad University, Arak Branch, Arak, Iran

    Fardin Faraji

  5. Department of Biology, Payame Noor University, Tehran, Iran

    Ali Akbar Malekirad

Authors
  1. Afsoon Talaie
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  2. Hanieh Jafary
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  4. Ali Akbar Malekirad
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Corresponding author

Correspondence to Hanieh Jafary.

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Ethics Approval

This study was approved by the ethics committee of Science and Research Branch, Islamic Azad University, Tehran, Iran (Code: IR.IAU.SRB.REC.1397.167).

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Informed consent was obtained from all participants included in the study.

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The original version of this article was revised due to the incorrect author name. The name of Afsoon Talaie is now corrected in the author group.

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Talaie, A., Jafary, H., Faraji, F. et al. The Serum Oxidative Stress Biomarkers and Selenium Levels in a Group of Migraine Patients Compared with Healthy Controls: a Case–Control Study. Biol Trace Elem Res 200, 4250–4255 (2022). https://doi.org/10.1007/s12011-021-03024-2

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