Abstract
Herbal medicines are widely consumed by the people of Pakistan for the treatment of various diseases. In the current study, quantitative assessment of four heavy metals namely zinc, lead, chromium, and cobalt was carried out in forty commonly consumed herbal medicines purchased from the markets of Khairpur and Sukkur, Pakistan. The conventional wet acid digestion method was used for the dissolution of samples and the concentration of heavy metals was determined by using flame atomic absorption spectrometry. Varied concentrations of metals were observed in different herbal medicines. The levels of Zn, Pb, Cr, and Co were in the range of 7.05–87.5 ppm, 5.62–44.9 ppm, 3.16–14.1 ppm, and 5.69–9.88 ppm, respectively. The findings of our study were compared with the WHO maximum permissible limits of these metals and it was observed that most of the analyzed samples exceeded the permissible levels. Keeping in view the levels of these metals in the selected herbal medicines, the prolonged intake of these drugs might be hazardous for human beings.
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References
Tilburt JC, Kaptchuk TJ (2008) Herbal medicine research and global health: an ethical analysis. Bull World Health Organ 86:594–599
Nkansah MA, Hayford ST, Borquaye LS, Ephraim JH (2016) Heavy metal contents of some medicinal herbs from Kumasi, Ghana. Cogent Environ Sci 2(1):1234660
Behera B, Bhattacharya S (2016) The importance of assessing heavy metals in medicinal herbs: a quantitative study. TANG 6(1):37–40
Saeed M, Muhammad N, Khan H (2011) Assessment of heavy metal content of branded Pakistani herbal products. Trop J Pharm Res 10(4):499–506
Begum H, Humayun M, Zaman K, Shinwari Z, Hussain A (2017) Heavy metal analysis in frequently consumable medicinal plants of Khyber Pakhtunkhwa, Pakistan. Pak J Bot 49(3):1155–1160
Ernst E (2002) Toxic heavy metals and undeclared drugs in Asian herbal medicines. Trends Pharmacol Sci 23(3):136–139
Hussain I, Khan F, Khan I, Khan L, Wali-Ullah (2006) Determination of heavy metals in medicinal plants. J Chem Soc Pak 28 (4):347-351
Saeed M, Khan H, Khan MA, Khan F, Khan SA, Muhammad N (2010) Quantification of various metals and cytotoxic profile of aerial parts of Polygonatum verticillatum. Pak J Bot 42(6):3995–4002
Dghaim R, Al Khatib S, Rasool H, Ali Khan M (2015) Determination of heavy metals concentration in traditional herbs commonly consumed in the United Arab Emirates. J Environ Public Health 2015
Çelik U, Oehlenschläger J (2007) High contents of cadmium, lead, zinc and copper in popular fishery products sold in Turkish supermarkets. Food Control 18(3):258–261
Joseph B, Raj S, Edwin B, Sankarganesh P, Jeevitha M, Ajisha S, Sheeja S (2010) Toxic effect of heavy metals on aquatic environment. Int J Biol Chem Sci 4(4):939–952
Talpur S, Afridi HI, Kazi TG, Talpur FN (2018) Interaction of lead with calcium, iron, and zinc in the biological samples of malnourished children. Biol Trace Elem Res 183(2):209–217
Shah F, Ullah N, Kazi TG, Khan A, Kandhro GA, Afridi HI, Arain MB, Khan Z, Farooq U (2016) Lead assessment in biological samples of children with different gastrointestinal disorders. Biol Trace Elem Res 169(1):41–45
Naeemullah KTG, Afridi HI, Shah F, Arain SS, Brahman KD, Ali J, Arain MS (2016) Simultaneous determination of silver and other heavy metals in aquatic environment receiving wastewater from industrial area, applying an enrichment method. Arab J Chem 9(1):105–113. https://doi.org/10.1016/j.arabjc.2014.10.027
Zhong W-S, Ren T, Zhao L-J (2016) Determination of Pb (Lead), Cd (Cadmium), Cr (Chromium), Cu (Copper), and Ni (Nickel) in Chinese tea with high-resolution continuum source graphite furnace atomic absorption spectrometry. J Food Drug Anal 24(1):46–55
Rahimi M, Farhadi R, Balashahri MS (2012) Effects of heavy metals on the medicinal plant. Int J Agron Plant Prod 3(4):154–158
Saper RB, Kales SN, Paquin J, Burns MJ, Eisenberg DM, Davis RB, Phillips RS (2004) Heavy metal content of ayurvedic herbal medicine products. Jama 292(23):2868–2873
Harris ES, Cao S, Littlefield BA, Craycroft JA, Scholten R, Kaptchuk T, Fu Y, Wang W, Liu Y, Chen H (2011) Heavy metal and pesticide content in commonly prescribed individual raw Chinese Herbal Medicines. Sci Total Environ 409(20):4297–4305
Alwakeel SS (2008) Microbial and heavy metals contamination of herbal medicines. Res J Microbiol 3(12):683–691
World Health Organization (2007) WHO guidelines for assessing quality of herbal medicines with reference to contaminants and residues. World Health Organization
Kulhari A, Sheorayan A, Bajar S, Sarkar S, Chaudhury A, Kalia RK (2013) Investigation of heavy metals in frequently utilized medicinal plants collected from environmentally diverse locations of north western India. SpringerPlus 2(1):676
Hussain J, Rehman N, Shinwari ZK, Khan AL, Al-Harrasi A, Ali L, Mabood F (2014) Preliminary comparative analysis of four botanicals used in the traditional medicines of Pakistan. Pak J Bot 46(4):1403–1407
Shinwari ZK, Salima M, Faisal R, Huda S, Asrar M (2013) Biological screening of indigenous knowledge based plants used in diarrheal treatment. Pak J Bot 45(4):1375–1382
Khalil AT, Shinwari ZK, Qaiser M, Marwat KB (2014) Phyto-therapeutic claims about euphorbeaceous plants belonging to Pakistan; an ethnomedicinal review. Pak J Bot 46(3):1137–1144
Singh KP, Bhattacharya S, Sharma P (2014) Assessment of heavy metal contents of some Indian medicinal plants. American-Eurasian J Agric Environ Sci 14(10):1125–1129
Kohzadi S, Shahmoradi B, Ghaderi E, Loqmani H, Maleki A (2019) Concentration, source, and potential human health risk of heavy metals in the commonly consumed medicinal plants. Biol Trace Elem Res 187(1):41–50
Khan MU, Mahmood A, Malik RN (2015) Assessment of heavy metals in pharmacological important medicinal plants consumed in the Bannu District, Pakistan. Human Ecol Risk Assess 21(7):1782–1792
Mahmood A, Rashid S, Malik RN (2013) Determination of toxic heavy metals in indigenous medicinal plants used in Rawalpindi and Islamabad cities, Pakistan. J Ethnopharmacol 148(1):158–164
Annan K, Dickson RA, Amponsah IK, Nooni IK (2013) The heavy metal contents of some selected medicinal plants sampled from different geographical locations. Pharm Res 5(2):103–108
Bellinger DC (2008) Very low lead exposures and children’s neurodevelopment. Curr Opin Pediatr 20(2):172–177
Vincent JB, Lukaski HC (2018) Chromium. Adv Nutr 9(4):505–506. https://doi.org/10.1093/advances/nmx021
Vincent JB (2010) Chromium: celebrating 50 years as an essential element? Dalton Trans 39(16):3787–3794
Ahmed MJ, Uddin MN (2007) A simple spectrophotometric method for the determination of cobalt in industrial, environmental, biological and soil samples using bis (salicylaldehyde) orthophenylenediamine. Chemosphere 67(10):2020–2027
Orisakwe OE, Kanayochukwu NJ, Nwadiuto AC, Daniel D, Onyinyechi O (2012) Evaluation of potential dietary toxicity of heavy metals of vegetables. J Environ Anal Toxicol 2(3):136
Verma P, George KV, Singh H, Singh R (2007) Modeling cadmium accumulation in radish, carrot, spinach and cabbage. Appl Math Model 31(8):1652–1661
Ozyigit II, Yalcin B, Turan S, Saracoglu IA, Karadeniz S, Yalcin IE, Demir G (2018) Investigation of heavy metal level and mineral nutrient status in widely used medicinal plants’ leaves in Turkey: insights into health implications. Biol Trace Elem Res 182(2):387–406
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Maitlo, A.A., Jatoi, W.B., Memon, A.F. et al. Assessment of Zinc, Lead, Chromium, and Cobalt in Commonly Consumed Herbal Medicines in Sindh, Pakistan. Biol Trace Elem Res 199, 2366–2374 (2021). https://doi.org/10.1007/s12011-020-02339-w
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DOI: https://doi.org/10.1007/s12011-020-02339-w