Abstract
The complex bis(4,7-dimethyl-1,10-phenantroline)sulfatooxidovanadium(IV), commonly known as Metvan, was prepared using a known synthetic procedure. Its optimized molecular structure was obtained by DFT calculations, as it was impossible to grow single crystals adequate for a crystallographic study. The complex was also characterized by a detailed analysis of its infrared spectrum, supported by the theoretical calculations, and also by some data derived from its Raman spectrum. In addition, cytotoxicity studies were performed using human osteosarcoma (MG-63) and human colorectal adenocarcinoma (HT-29) cell lines. The results show that Metvan impaired cell viability of both cancer cell lines in a low concentration range (0.25–5.0 μM).
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Funding
This research was supported by the Universidad Nacional de La Plata (Projects X/690 and X/673), the Agencia Nacional de Promoción Científica y Tecnológica-ANPCyT (PICT 2014-2223), and the Consejo Nacional de Investigaciones Científicas y Técnicas-CONICET (PIP 0034). IEL and BSPC are members of the Research Career from CONICET; MCR has a fellowship from CONICET.
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León, I.E., Ruiz, M.C., Franca, C.A. et al. Metvan, bis(4,7-Dimethyl-1,10-phenanthroline)sulfatooxidovanadium(IV): DFT and Spectroscopic Study—Antitumor Action on Human Bone and Colorectal Cancer Cell Lines. Biol Trace Elem Res 191, 81–87 (2019). https://doi.org/10.1007/s12011-018-1597-2
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DOI: https://doi.org/10.1007/s12011-018-1597-2