Abstract
A trend toward the use of traditional and herbal medicines has developed nowadays, and there is a growing concern regarding them being polluted with heavy metals. This study measured the heavy metal concentrations in eight different types of medicinal herbs and eight different types of herbal distillates sold in the markets in Sanandaj, Kurdistan, Iran. The concentration of some metals (Cd, Cu, Mn, Fe, Zn, Al, Co, Ni, Cr, Pb, and Mg) was quantified by inductively coupled plasma mass spectrometry, and the associated health risk for adults and children was estimated. The mean concentration of all the metals was within the permissible limits set by the WHO. The medicinal herbs contained significantly more Al, As, Cd, Cr, Fe, Mn, Ni, Pb, and Zn (p < 0.02) than the herbal distillates. However, the concentrations of Cu and Hg were higher in the herbal distillates. The non-carcinogenic risks of consumption of traditional medicines in adults and children were assessed based on the target hazard quotients (THQs). The THQs for individual metals (except Al and Cr) from individual herbs were less than 1, which is considered as safe for human consumption.
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Awodele O, Popoola T, Amadi K, Coker H, Akintonwa A (2013) Traditional medicinal plants in Nigeria—remedies or risks. J Ethnopharmacol 150(2):614–618
Khan MU, Malik RN, Muhammad S (2013) Human health risk from heavy metal via food crops consumption with wastewater irrigation practices in Pakistan. Chemosphere 93(10):2230–2238
Street R (2012) Heavy metals in medicinal plant products—an African perspective. S Afr J Bot 82:67–74
Zhao Q, Wang Y, Cao Y, Chen A, Ren M, Ge Y, Yu Z, Wan S, Hu A, Bo Q (2014) Potential health risks of heavy metals in cultivated topsoil and grain, including correlations with human primary liver, lung and gastric cancer, in Anhui province, Eastern China. Sci Total Environ 470:340–347
Huang Z, Pan X-D, Wu P-G, Han J-L, Chen Q (2014) Heavy metals in vegetables and the health risk to population in Zhejiang, China. Food Control 36(1):248–252
Dzomba P, Chayamiti T, Togarepi E (2012) Heavy metal content of selected raw medicinal plant materials: implication for patient health
Dghaim R, Al Khatib S, Rasool H, Ali Khan M (2015) Determination of heavy metals concentration in traditional herbs commonly consumed in the United Arab Emirates. J Environ Public Health 2015:1–6
Harrison RM, Chirgawi M (1989) The assessment of air and soil as contributors of some trace metals to vegetable plants I. Use of a filtered air growth cabinet. Sci Total Environ 83(1–2):13–34
Wild E, Dent J, Thomas GO, Jones KC (2005) Direct observation of organic contaminant uptake, storage, and metabolism within plant roots. Environ Sci Technol 39(10):3695–3702
Gasser U, Klier B, Kuhn A, Steinhoff B (2009) Current findings on the heavy metal content in herbal drugs. Pharmeuropa 1:37–49
Sahoo N, Manchikanti P, Dey S (2010) Herbal drugs: standards and regulation. Fitoterapia 81(6):462–471
Obi E, Akunyili DN, Ekpo B, Orisakwe OE (2006) Heavy metal hazards of Nigerian herbal remedies. Sci Total Environ 369(1):35–41
Okatch H, Ngwenya B, Raletamo KM, Andrae-Marobela K (2012) Determination of potentially toxic heavy metals in traditionally used medicinal plants for HIV/AIDS opportunistic infections in Ngamiland District in Northern Botswana. Anal Chim Acta 730:42–48
Steenkamp V, Stewart MJ, Curowska E, Zuckerman M (2002) A severe case of multiple metal poisoning in a child treated with a traditional medicine. Forensic Sci Int 128(3):123–126
Mousavi Z, Ziarati P, Esmaeli Dehaghi M, Qomi M (2014) Heavy metals (lead and cadmium) in some medicinal herbal products in Iranian market. Iran J Toxicol 8(24):1004–1010
Mahmood A, Malik RN (2014) Human health risk assessment of heavy metals via consumption of contaminated vegetables collected from different irrigation sources in Lahore, Pakistan. Arab J Chem 7(1):91–99
Chen J, Jia M (2005) Regulation and analysis on limit contents for heavy metals and pesticide residues in medicinal plants from the pharmacopoeias of China, the United States, Britain, Japan and Europe. West China J Pharm Sci 20(6):525
Ghani A, Ali Z, Ishtiaq M, Maqbool M, Parveen S (2012) Estimation of macro and micro nutrients in some important medicinal plants of Soon Valley, District Khushab, Pakistan. Afr J Biotechnol 11(78):14386–14391
Rahimi M, Farhadi R, Balashahri M (2012) Effects of heavy metals on the medicinal plant. Int J Agron Plant Prod 3(4):154–158
Arumugam R, Kannan RRR, Jayalakshmi J, Manivannan K, Devi GK, Anantharaman P (2012) Determination of element contents in herbal drugs: chemometric approach. Food Chem 135(4):2372–2377
Mahmood A, Rashid S, Malik RN (2013) Determination of toxic heavy metals in indigenous medicinal plants used in Rawalpindi and Islamabad cities, Pakistan. J Ethnopharmacol 148(1):158–164
USEPA U (1997) Exposure factors handbook. Office of Research and Development, Washington
Zhuang P, Lu H, Li Z, Zou B, McBride MB (2014) Multiple exposure and effects assessment of heavy metals in the population near mining area in South China. PLoS One 9(4):e94484
Sohrabi M, Beigmohammadi Z, Cheraghi M, Majidifar S, Jahangard A (2015) Health risks of heavy metals for population via consumption of greenhouse vegetables in Hamadan, Iran. Arch Hyg Sci 4(4):165–171
Pastorok P (1987) Guidance manual for assessing human health risks from chemically contaminated fish and shellfish. PTI Environmental Service’s submission to Battelle New England for EPA, Washington, DEC PTI Environ Draft Report C737-01 Bellevue, Washington 91
PA USEPAUIRIS-dP (2007). Washington, DC
Islam MS, Ahmed MK, Habibullah-Al-Mamun M, Masunaga S (2014) Trace metals in soil and vegetables and associated health risk assessment. Environ Monit Assess 186(12):8727–8739
USEPA (2010) Risk based ConcentrationTable Available from : 〈http://www.epa.gov/reg3hwmd/risk/human/index.htm〉
Organization WH (2007) WHO guidelines for assessing quality of herbal medicines with reference to contaminants and residues. World Health Organization, Geneva
Maobe MA, Gatebe E, Gitu L, Rotich H (2012) Profile of heavy metals in selected medicinal plants used for the treatment of diabetes, malaria and pneumonia in Kisii region, southwest Kenya. Glob J Pharmacol 6(3):245–251
Jabeen S, Shah MT, Khan S, Hayat MQ (2010) Determination of major and trace elements in ten important folk therapeutic plants of Haripur basin, Pakistan. J Med Plants Res 4(7):559–566
Khan SA, Khan L, Hussain I, Marwat KB, Akhtar N (2008) Profile of heavy metals in selected medicinal plants. Pak J Weed Sci Res 14(1–2):101–110
Abu-Darwish MS, Abu-Dieyeh ZH (2009) Essential oil content and heavy metals composition of Thymus vulgaris cultivated in various climatic regions of Jordan. Int J Agric Biol 11:59–63
Singh KP, Bhattacharya S, Sharma P (2014) Assessment of heavy metal contents of some Indian medicinal plants. Am Eurasian J Agric Environ Sci 14(10):1125–1129
FAO/WHO (1984) Contaminants, vol XVII. FAO/WHO, Rome
Volesky B, Holan Z (1995) Biosorption of heavy metals. Biotechnol Prog 11(3):235–250
Kulhari A, Sheorayan A, Bajar S, Sarkar S, Chaudhury A, Kalia RK (2013) Investigation of heavy metals in frequently utilized medicinal plants collected from environmentally diverse locations of north western India. SpringerPlus 2(1):1
Ullah R, Khader JA, Hussain N, AbdElsalam NM, Talha M, Khan N (2012) Investigation of macro and micro-nutrients in selected medicinal plants. Afr J Pharm Pharmacol 6(25):1829–1832
Vaikosen EN, Alade GO (2011) Evaluation of pharmacognostical parameters and heavy metals in some locally manufactured herbal drugs. J Chem Pharm Res 3:88–97
Kulhari A, Sheorayan A, Bajar S, Sarkar S, Chaudhury A, Kalia RK (2013) Investigation of heavy metals in frequently utilized medicinal plants collected from environmentally diverse locations of north western India. SpringerPlus 2(1):676
Pendias A, Pendias H (1992) Elements of group VIII. Trace elements in soils and plants. CRC Press, Boca Raton, pp 271–276
Lokeshappa B, Shivpuri K, Tripathi V, Dikshit A (2012) Assessment of toxic metals in agricultural produce. Food Public Health 2(1):24–29
Raouf ALM, Hammud KK, Zamil SK (2014) Macro-and trace metals in three medicinal herbs collected from Baghdad, Iraq market. Int J Pharm Sci Res 5(11):799–802
Kirmani MZ, Mohiuddin S, Naz F, Naqvi II, Zahir E (2011) Determination of some toxic and essential trace metals in some medicinal and edible plants of Karachi city. J Basic Appl Sci 7(2):89–95
Abu-Darwish MS (2014) Heavy metals in selected medicinal plants originated in Dana Biosphere Reserve, Jordan. Int J Phytomedicine 6(3):384–390
Klotz K, Weistenhöfer W, Neff F, Hartwig A, van Thriel C, Drexler H (2017) The health effects of aluminum exposure. Dtsch Arztebl Int 114(39):653–659. https://doi.org/10.3238/arztebl.2017.0653
Ratnaike RN (2003) Acute and chronic arsenic toxicity. Postgrad Med J 79(933):391–396
Zhuang P, McBride MB, Xia H, Li N, Li Z (2009) Health risk from heavy metals via consumption of food crops in the vicinity of Dabaoshan mine, South China. Sci Total Environ 407(5):1551–1561
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This study received financial support from the Deputy of Research, Kurdistan University of Medical Sciences (grant number: IR.MUK.REC. 1393-108).
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Kohzadi, S., Shahmoradi, B., Ghaderi, E. et al. Concentration, Source, and Potential Human Health Risk of Heavy Metals in the Commonly Consumed Medicinal Plants. Biol Trace Elem Res 187, 41–50 (2019). https://doi.org/10.1007/s12011-018-1357-3
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DOI: https://doi.org/10.1007/s12011-018-1357-3