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Disparities of Selected Metal Levels in the Blood and Scalp Hair of Ischemia Heart Disease Patients and Healthy Subjects

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Abstract

Imbalances in the concentrations of trace metals have become an increasingly recognized source of infirmity worldwide particularly in the development of ischemia heart disease (IHD). Present study is intended to analyze the concentrations of Ca, Cd, Co, Cr, Cu, Fe, K, Li, Mg, Mn, Na, Pb, Sr, and Zn in the blood and scalp hair of the patients and counterpart controls by flame atomic absorption spectrometry after wet-acid digestion. On the average, Cd, Co, Cr, Fe, K, Li, Mn, Na, and Pb revealed significantly elevated concentrations in the blood of the patients compared with the controls (p < 0.05), whereas mean levels of Ca, Cd, Fe, K, Li, Pb, and Sr in the scalp hair were significantly higher in the patients than the controls (p < 0.05). Most of the metals exhibited noticeable disparities in their concentrations based on gender, abode, dietary/smoking habits, and occupations of both donor groups. The correlation study and multivariate statistical analyses revealed some significantly divergent associations and apportionment of the metals in both donor groups. Overall, comparative variations of the metal contents in blood/scalp hair of the patients were significantly different than the controls; thus, evaluation of trace metals status may be indicative of pathological disorders, such as IHD.

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Acknowledgments

The funding by Higher Education Commission (HEC), Government of Pakistan, to carry out this project is thankfully acknowledged. We are also grateful to the administrations of Department of Cardiology, Jinnah Hospital, Lahore; Punjab Institute of Cardiology, Lahore; Pakistan Institute of Medical Sciences, Islamabad; Polyclinic Hospital, Islamabad; and Benazir Bhutto Hospital, Rawalpindi, Pakistan, for their invaluable help during the sample collection. Technical and financial help by Quaid-i-Azam University, Islamabad, Pakistan, to execute this project is also acknowledged.

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Authors and Affiliations

  1. Department of Chemistry, Quaid-i-Azam University, Islamabad, 45320, Pakistan

    Asim Ilyas & Munir H. Shah

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  1. Asim Ilyas
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  2. Munir H. Shah
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Correspondence to Munir H. Shah.

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Ilyas, A., Shah, M.H. Disparities of Selected Metal Levels in the Blood and Scalp Hair of Ischemia Heart Disease Patients and Healthy Subjects. Biol Trace Elem Res 180, 191–205 (2017). https://doi.org/10.1007/s12011-017-1021-3

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  • DOI: https://doi.org/10.1007/s12011-017-1021-3

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