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Selenium Content in the Liver of Wistar Rats Fed Diets of Different Fatty Acid Quality

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Abstract

The purpose of this work was to measure the amounts of selected mineral elements (sodium, calcium, iron, selenium, magnesium, zinc, copper, and manganese) in the liver of Wistar rats and evaluate possible correlations between the levels of these minerals and the lipid metabolism in the studied animals. Three experimental groups each containing six Wistar rats were designed. Each group was fed a different diet. The control group was fed a diet prepared with fresh soybean oil and named control group—CG. The second group (named experimental group B—EGB) and third group (named experimental group C—EGC) were fed a diet containing soybean oil that had been used to fry different foods for four or ten cycles, respectively. The mineral elements in Wistar rat livers were measured by inductively coupled plasma optical emission spectrometry (ICP OES). Only the elements calcium and selenium differed significantly between the control and experimental groups. There was a significant reduction of 33 % for Ca and 41 % for Se in the EGB in comparison to the control group. The reduction in mineral concentration, especially Se, is the result of interactions with fatty acid metabolism. The animals in the EGC exhibited more intracytoplasmic accumulation of fat and more intense vasodilatation, in relation to the other groups. Collectively, evidence hereby collected suggests that impaired dietary lipid quality in otherwise balanced diets can reduce hepatic Se levels and potentially harm liver function.

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Acknowledgments

The authors wish to acknowledge the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, 475055/2011-0 and 301689/2011-3), the Fundação de Amparo à Pesquisa do Estado de Minas Gerais of Brazil (FAPEMIG-CEX-PPM 00398-13 and CEX-RED-0010-14 from Rede Mineira de Química), the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) for fellowships and financial support and the Center for Reproductive Biology—UFJF.

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Authors and Affiliations

  1. Chemistry Department, Institute of Exact Sciences, Federal University of Juiz de Fora, Juiz de Fora, MG, Brazil

    Patrícia Mendonça de Castro Barra, Rafael Arromba de Sousa & Marcone Augusto Leal de Oliveira

  2. Nutrition Department, Federal University of Juiz de Fora, Juiz de Fora, MG, Brazil

    Céphora Maria Sabarense

  3. EMBRAPA Gado de Leite, Juiz de Fora, MG, Brazil

    Marcelo Bonnet Alvarenga

Authors
  1. Patrícia Mendonça de Castro Barra
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  2. Céphora Maria Sabarense
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  3. Marcelo Bonnet Alvarenga
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  4. Rafael Arromba de Sousa
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  5. Marcone Augusto Leal de Oliveira
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Correspondence to Marcone Augusto Leal de Oliveira.

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de Castro Barra, P.M., Sabarense, C.M., Alvarenga, M.B. et al. Selenium Content in the Liver of Wistar Rats Fed Diets of Different Fatty Acid Quality. Biol Trace Elem Res 168, 441–446 (2015). https://doi.org/10.1007/s12011-015-0359-7

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  • DOI: https://doi.org/10.1007/s12011-015-0359-7

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