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Oxidative Stress and Imbalance of Mineral Metabolism Contribute to Lameness in Dairy Cows

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Abstract

The objective of this study was to investigate correlations between oxidative stress, metabolism of mineral elements, and lameness in dairy cows. Forty multiparous Chinese Holstein dairy cows were selected and divided into two groups (healthy vs lame, n = 20) by gait score. The experiment lasted for 60 days and samples of hair, blood, and hoof were collected at days 0, 30, and 60 of experiment period, individually. Compared with healthy cows, elevation of MDA, CTX-II, COMP levels, and GSSG/GSH ratio together with depletion of SOD and MT levels in the serum were revealed in lame cows. Simultaneously, significant decreased contents of Zn, Cu, and Mn in the serum, hair, and hoof samples were shown in lame cows, but there was no obvious difference in contents of P, Mg, and Ca (except hoof Ca) in the serum, hair, and hoof between healthy and lame cows. In addition, histological examination and the hardness test demonstrated a poor hoof quality in lame cows. In summary, oxidative stress is implicated in the pathogenesis of lameness caused by imbalance of nutrients (especially selective minerals promoting healthy hoof growth) in dairy cows.

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Acknowledgments

This work was supported by postdoctoral foundation of Shandong Agricultural University (76405) and project of National Undergraduate Training Programs for Innovation and Entrepreneurship (201310434003).

Conflict of interest

None of the authors has any financial or personal relationships that could inappropriately influence or bias the content of the paper.

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Authors and Affiliations

  1. College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Taian, 271018, People’s Republic of China

    Xue-Jun Zhao, Xin-Yu Wang, Zhen-Yong Wang, Lin Wang & Zhong-Hua Wang

  2. College of Animal Science, Zhejiang University, Hangzhou, 310058, People’s Republic of China

    Jun-Hong Wang

Authors
  1. Xue-Jun Zhao
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  2. Xin-Yu Wang
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  3. Jun-Hong Wang
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  4. Zhen-Yong Wang
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  5. Lin Wang
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  6. Zhong-Hua Wang
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Corresponding authors

Correspondence to Lin Wang or Zhong-Hua Wang.

Additional information

Xue-Jun Zhao and Xin-Yu Wang contributed equally to this work.

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Zhao, XJ., Wang, XY., Wang, JH. et al. Oxidative Stress and Imbalance of Mineral Metabolism Contribute to Lameness in Dairy Cows. Biol Trace Elem Res 164, 43–49 (2015). https://doi.org/10.1007/s12011-014-0207-1

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  • DOI: https://doi.org/10.1007/s12011-014-0207-1

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