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Investigation of Paracetamol Entrapped Nanoporous Silica Nanoparticles in Transdermal Drug Delivery System

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Abstract

An effort was made to administer paracetamol drug through transdermal patch, as no such formulation of this drug has been developed yet. The primary cause for the lack of such formulations is paracetamol’s poor aqueous solubility. As a result, the current research concentrated on preparing nanomedicines, or drug-loaded nanoparticles, for delivery via transdermal formulations. Nanoparticles can improve the solubility of weakly aqueous soluble or even aqueous insoluble drugs by changing the crystalline structure of loaded medicines to an amorphous state and serving as drug permeation boosters. Silica nanoparticles (SNPs) were synthesized through sol-gel technique to achieve the aforementioned goal. DLS data revealed that the average particle size was around 100–200 nm, which was sufficient to penetrate the skin barrier. XRD analysis showed that the SNPs were amorphous, and the drug molecules lost their crystallinity after encapsulation into the nanoparticles, causing the enhancement of dissolution of drug molecules in physiological pH (pH—7.4). Different kinetic models were employed for the ex vivo dissolution data to evaluate the suitable kinetic model followed by the drug release in both burst and sustained phase. In vivo analgesic study was executed on mice applying each of the transdermal formulations to examine the performances of the patches.

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Data Availability

The data used to support the findings of this study are available from the corresponding author upon request.

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Funding

This work was supported by the Department of Higher Education, Science & Technology and Biotechnology, Government of West Bengal (File no: ST/P/S&T/6G-32/2017).

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Authors and Affiliations

  1. School of Materials Science and Nanotechnology, Jadavpur University, Kolkata, India

    Sourav Adhikary

  2. Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India

    Ashique Al Hoque & Manisheeta Ray

  3. Department of Coatings and Polymeric Materials, North Dakota State University, Fargo, ND, 58108, USA

    Ashique Al Hoque

  4. Department of Chemical Engineering, University of Calcutta, Kolkata, India

    Swastik Paul

  5. Department of Chemistry, Jadavpur University, Kolkata, India

    Akbar Hossain

  6. Department of Labour, ESI Institute of Pain Management, Kolkata, India

    Subrata Goswami

  7. Metallurgical and Material Engineering Department, Jadavpur University, Kolkata, India

    Rajib Dey

Authors
  1. Sourav Adhikary
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  2. Ashique Al Hoque
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Contributions

Sourav Adhikary: conceptualization, data curation, formal analysis, investigation, methodology, writing—original draft. Ashique Al Hoque: conceptualization, methodology, writing—review and editing. Manisheeta Ray: visualization, validation. Swastik Paul: investigation, validation. Akbar Hossain: data analysis. Subrata Goswami: resources, supervision. Rajib Dey: project administration, resources, supervision.

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Correspondence to Sourav Adhikary.

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Adhikary, S., Al Hoque, A., Ray, M. et al. Investigation of Paracetamol Entrapped Nanoporous Silica Nanoparticles in Transdermal Drug Delivery System. Appl Biochem Biotechnol 195, 4712–4727 (2023). https://doi.org/10.1007/s12010-023-04576-w

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  • DOI: https://doi.org/10.1007/s12010-023-04576-w

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