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Controlled Release System by Active Gelatin Film Incorporated with β-Cyclodextrin-Thymol Inclusion Complexes

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Abstract

Essential oils such as thymol are added to food packaging film to obtain active films with antimicrobial and antioxidant properties. However, thymol is insoluble in water, and release rate of thymol is usually too fast. Therefore, a need exists to increase thymol solubility and to deliver thymol in a controlled manner from film matrix to food surface. In this study, spray dried inclusion complexes of β-cyclodextrin/thymol (1:1 molar ratio) was incorporated into gelatin solution to obtain active gelatin films. Both inclusion complexes and active films showed sustained release of thymol. Physical properties and thymol release kinetics were evaluated for active films. For gelatin films with 8.25% (mass ratio) inclusion complexes, complete thymol release took 235 h, compared with 38 h for thymol release from inclusion complexes. The diffusion coefficient reached 2.04 × 10−15 m2 s−1.

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References

  • Achet, D., & He, X. (1995). Determination of the renaturation level in gelatin films. Polymer, 36(4), 787–791.

    Article  CAS  Google Scholar 

  • Ahmad, M., Benjakul, S., Prodpran, T., & Agustini, T. W. (2012). Physico-mechanical and antimicrobial properties of gelatin film from the skin of unicorn leatherjacket incorporated with essential oils. Food Hydrocolloids, 28(1), 189–199. https://doi.org/10.1016/j.foodhyd.2011.12.003.

    Article  CAS  Google Scholar 

  • Akcan, T., Estevez, M., & Serdaroglu, M. (2017). Antioxidant protection of cooked meatballs during frozen storage by whey protein edible films with phytochemicals from Laurus nobilis L. and Salvia officinalis. LWT - Food Science and Technology, 77, 323–331.

    Article  CAS  Google Scholar 

  • Al-Nasiri, G., Cran, M. J., Smallridge, A. J., & Bigger, S. W. (2018). Optimisation of β-cyclodextrin inclusion complexes with natural antimicrobial agents: thymol, carvacrol and linalool. Journal of Microencapsulation, 35(1), 26–35.

    Article  CAS  PubMed  Google Scholar 

  • Arcan, I., & Yemeniciogglu, A. (2014). Controlled release properties of zein–fatty acid blend films for multiple bioactive compounds. Journal of Agricultural and Food Chemistry, 62(32), 8238–8246.

    Article  CAS  PubMed  Google Scholar 

  • Arfat, Y. A., Benjakul, S., Prodpran, T., Sumpavapol, P., & Songtipya, P. (2014). Properties and antimicrobial activity of fish protein isolate/fish skin gelatin film containing basil leaf essential oil and zinc oxide nanoparticles. Food Hydrocolloids, 41, 265–273. https://doi.org/10.1016/j.foodhyd.2014.04.023.

    Article  CAS  Google Scholar 

  • Arvanitoyannis, I., Nakayama, A., & Aiba, S.-i. (1998). Edible films made from hydroxypropyl starch and gelatin and plasticized by polyols and water. Carbohydrate Polymers, 36(2–3), 105–119.

    Article  CAS  Google Scholar 

  • Barba, C., Eguinoa, A., & Mate, J. I. (2015). Preparation and characterization of β-cyclodextrin inclusion complexes as a tool of a controlled antimicrobial release in whey protein edible films. LWT - Food Science and Technology, 64(2), 1362–1369. https://doi.org/10.1016/j.lwt.2015.07.060.

    Article  CAS  Google Scholar 

  • Barnes, K., Sinclair, R., & Watson, D. (2006). Chemical migration and food contact materials. Woodhead Publishing.

  • Bruschi, M. L., Cardoso, M. L. C., Lucchesi, M. B., & Gremiao, M. P. D. (2003). Gelatin microparticles containing propolis obtained by spray-drying technique: preparation and characterization. International Journal of Pharmaceutics, 264(1), 45–55. https://doi.org/10.1016/S0378-5173(03)00386-7.

    Article  CAS  PubMed  Google Scholar 

  • Cevallos, P. A. P., Buera, M. P., & Elizalde, B. E. (2010). Encapsulation of cinnamon and thyme essential oils components (cinnamaldehyde and thymol) in β-cyclodextrin: effect of interactions with water on complex stability. Journal of Food Engineering, 99(1), 70–75.

    Article  CAS  Google Scholar 

  • Chen, Y., Ye, R., Li, X., & Wang, J. (2013). Preparation and characterization of extruded thermoplastic zein–poly (propylene carbonate) film. Industrial Crops and Products, 49, 81–87.

    Article  CAS  Google Scholar 

  • Cho, S. Y., Lee, S. Y., & Rhee, C. (2010). Edible oxygen barrier bilayer film pouches from corn zein and soy protein isolate for olive oil packaging. LWT - Food Science and Technology, 43(8), 1234–1239.

    Article  CAS  Google Scholar 

  • Crank, J. (1979). The mathematics of diffusion (2nd ed.). Oxford: Oxford University Press.

    Google Scholar 

  • Dainelli, D., Gontard, N., Spyropoulos, D., Zondervan-van den Beuken, E., & Tobback, P. (2008). Active and intelligent food packaging: legal aspects and safety concerns. Trends in Food Science & Technology, 19(Supplement 1), S103–S112. https://doi.org/10.1016/j.tifs.2008.09.011.

    Article  CAS  Google Scholar 

  • De Carvalho, R. A., & Grosso, C. R. F. (2004). Characterization of gelatin based films modified with transglutaminase, glyoxal and formaldehyde. Food Hydrocolloids, 18(5), 717–726. https://doi.org/10.1016/j.foodhyd.2003.10.005.

    Article  CAS  Google Scholar 

  • Dehghani, S., Hosseini, S. V., & Regenstein, J. M. (2018). Edible films and coatings in seafood preservation: a review. Food Chemistry, 240, 505–513.

    Article  CAS  PubMed  Google Scholar 

  • Del Nobile, M. A., Conte, A., Incoronato, A. L., & Panza, O. (2008). Antimicrobial efficacy and release kinetics of thymol from zein films. Journal of Food Engineering, 89(1), 57–63. https://doi.org/10.1016/j.jfoodeng.2008.04.004.

    Article  Google Scholar 

  • Fabra, M. J., Lopez-Rubio, A., & Lagaron, J. M. (2013). High barrier polyhydroxyalcanoate food packaging film by means of nanostructured electrospun interlayers of zein. Food Hydrocolloids, 32(1), 106–114.

    Article  CAS  Google Scholar 

  • Gemili, S., Yemenicioglu, A., & Altınkaya, S. A. (2010). Development of antioxidant food packaging materials with controlled release properties. Journal of Food Engineering, 96(3), 325–332.

    Article  CAS  Google Scholar 

  • Han, J. H. (2014). Edible films and coatings: a review. In J. H. Han (Ed.), Innovations in food packaging, (2nd ed., pp. 213–255). Elsevier.

  • Hoque, M. S., Benjakul, S., & Prodpran, T. (2011). Effects of partial hydrolysis and plasticizer content on the properties of film from cuttlefish (Sepia pharaonis) skin gelatin. Food Hydrocolloids, 25(1), 82–90.

    Article  CAS  Google Scholar 

  • Hou, L., Johnson, J. A., & Wang, S. (2016). Radio frequency heating for postharvest control of pests in agricultural products: a review. Postharvest Biology and Technology, 113, 106–118.

    Article  Google Scholar 

  • Janjarasskul, T., & Krochta, J. M. (2010). Edible packaging materials. Annual Review of Food Science and Technology, 1(1), 415–448.

    Article  CAS  PubMed  Google Scholar 

  • Kanmani, P., & Rhim, J.-W. (2014). Physical, mechanical and antimicrobial properties of gelatin based active nanocomposite films containing AgNPs and nanoclay. Food Hydrocolloids, 35, 644–652.

    Article  CAS  Google Scholar 

  • Karathanos, V. T., Mourtzinos, I., Yannakopoulou, K., & Andrikopoulos, N. K. (2007). Study of the solubility, antioxidant activity and structure of inclusion complex of vanillin with β-cyclodextrin. Food Chemistry, 101(2), 652–658.

    Article  CAS  Google Scholar 

  • Kurek, M., Scetar, M., & Galic, K. (2017). Edible coatings minimize fat uptake in deep fat fried products: a review. Food Hydrocolloids, 71, 225–235.

    Article  CAS  Google Scholar 

  • Li, M., & Ye, R. (2017). Edible active packaging for food application: materials and technology. In M. A. Masuelli (Ed.), Biopackaging (1st ed., p. 1). Boca Raton: CRC Press.

    Google Scholar 

  • Li, K.-K., Yin, S.-W., Yang, X.-Q., Tang, C.-H., & Wei, Z.-H. (2012). Fabrication and characterization of novel antimicrobial films derived from thymol-loaded zein–sodium caseinate (SC) nanoparticles. Journal of Agricultural and Food Chemistry, 60(46), 11592–11600.

    Article  CAS  PubMed  Google Scholar 

  • Mahdavi, S. A., Jafari, S. M., Assadpoor, E., & Dehnad, D. (2016). Microencapsulation optimization of natural anthocyanins with maltodextrin, gum Arabic and gelatin. International Journal of Biological Macromolecules, 85, 379–385.

    Article  CAS  Google Scholar 

  • Maisanaba, S., Llana-Ruiz-Cabello, M., Gutierrez-Praena, D., Pichardo, S., Puerto, M., Prieto, A., et al. (2017). New advances in active packaging incorporated with essential oils or their main components for food preservation. Food Reviews International, 33(5), 447–515.

    Article  CAS  Google Scholar 

  • Masamba, K., Li, Y., Hategekimana, J., Liu, F., Ma, J., & Zhong, F. (2016a). Effect of type of plasticizers on mechanical and water barrier properties of transglutaminase cross–linked zein–oleic acid composite films. International Journal of Food Engineering, 12(4), 365–376.

    Article  CAS  Google Scholar 

  • Masamba, K., Li, Y., Hategekimana, J., Zehadi, M., Ma, J., & Zhong, F. (2016b). Evaluation of mechanical and water barrier properties of transglutaminase crosslinked zein films incorporated with oleic acid. International Journal of Food Science and Technology.

  • Mastromatteo, M., Barbuzzi, G., Conte, A., & Del Nobile, M. (2009). Controlled release of thymol from zein based film. Innovative Food Science & Emerging Technologies, 10(2), 222–227.

    Article  CAS  Google Scholar 

  • Mastromatteo, M., Mastromatteo, M., Conte, A., & Del Nobile, M. A. (2010). Advances in controlled release devices for food packaging applications. Trends in Food Science & Technology, 21(12), 591–598.

    Article  CAS  Google Scholar 

  • Otoni, C. G., Avena-Bustillos, R. J., Azeredo, H., Lorevice, M. V., Moura, M. R., Mattoso, L. H., et al. (2017). Recent advances on edible films based on fruits and vegetables—a review. Comprehensive Reviews in Food Science and Food Safety, 16(5), 1151–1169.

    Article  Google Scholar 

  • Ouattara, B., Simard, R. E., Piette, G., Bégin, A., & Holley, R. A. (2000). Diffusion of acetic and propionic acids from chitosan-based antimicrobial packaging films. Journal of Food Science, 65(5), 768–773. https://doi.org/10.1111/j.1365-2621.2000.tb13584.x.

    Article  CAS  Google Scholar 

  • Pralhad, T., & Rajendrakumar, K. (2004). Study of freeze-dried quercetin–cyclodextrin binary systems by DSC, FT-IR, X-ray diffraction and SEM analysis. Journal of Pharmaceutical and Biomedical Analysis, 34(2), 333–339.

    Article  CAS  PubMed  Google Scholar 

  • Ramos, M., Beltran, A., Peltzer, M., Valente, A. J. M., & Garrigos, M. d. C. (2014). Release and antioxidant activity of carvacrol and thymol from polypropylene active packaging films. LWT - Food Science and Technology, 58(2), 470–477. https://doi.org/10.1016/j.lwt.2014.04.019.

    Article  CAS  Google Scholar 

  • Singh, M., Sharma, R., & Banerjee, U. C. (2002). Biotechnological applications of cyclodextrins. Biotechnology Advances, 20(5–6), 341–359. https://doi.org/10.1016/S0734-9750(02)00020-4.

    Article  CAS  PubMed  Google Scholar 

  • Souza, C. R., & Oliveira, W. P. (2006). Powder properties and system behavior during spray drying of Bauhinia forficata link extract. Drying Technology, 24(6), 735–749.

    Article  CAS  Google Scholar 

  • Sung, S.-Y., Sin, L. T., Tee, T.-T., Bee, S.-T., Rahmat, A. R., Rahman, W. A. W. A., Tan, A. C., & Vikhraman, M. (2013). Antimicrobial agents for food packaging applications. Trends in Food Science & Technology, 33(2), 110–123. https://doi.org/10.1016/j.tifs.2013.08.001.

    Article  CAS  Google Scholar 

  • Suppakul, P., Sonneveld, K., Bigger, S. W., & Miltz, J. (2011). Diffusion of linalool and methylchavicol from polyethylene-based antimicrobial packaging films. LWT - Food Science and Technology, 44(9), 1888–1893.

    Article  CAS  Google Scholar 

  • Tontul, I., & Topuz, A. (2017). Spray-drying of fruit and vegetable juices: effect of drying conditions on the product yield and physical properties. Trends in Food Science & Technology, 63, 91–102.

    Article  CAS  Google Scholar 

  • Umaraw, P., & Verma, A. K. (2017). Comprehensive review on application of edible film on meat and meat products: an eco-friendly approach. Critical Reviews in Food Science and Nutrition, 57(6), 1270–1279.

    Article  CAS  PubMed  Google Scholar 

  • Yamada, T., Imai, T., Ouchi, K., Otagiri, M., Hirayama, F., & Uekama, K. (2000). Inclusion complex of 3, 9-bis (N,N-dimethylcarbamoloxy)-5H-benzofuro [3, 2-c] quinoline-6-one (KCA-098) with Heptakis (2, 6-di-O-methyl)-b-cyclodextrin: interaction and dissolution properties. Chemical and Pharmaceutical Bulletin, 48(9), 1264–1269.

    Article  CAS  PubMed  Google Scholar 

  • Zhang, Y., Cui, L., Che, X., Zhang, H., Shi, N., Li, C., Chen, Y., & Kong, W. (2015). Zein-based films and their usage for controlled delivery: origin, classes and current landscape. Journal of Controlled Release, 206, 206–219.

    Article  CAS  PubMed  Google Scholar 

  • Zheng, J. P., Li, P., Ma, Y. L., & Yao, K. D. (2002). Gelatin/montmorillonite hybrid nanocomposite. I. Preparation and properties. Journal of Applied Polymer Science, 86(5), 1189–1194.

    Article  CAS  Google Scholar 

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Funding

This work was supported by National Key Technologies R&D Program (Grant No. 2016YFD0400800).

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Correspondence to Mengxing Li.

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Li, M., Zhang, F., Liu, Z. et al. Controlled Release System by Active Gelatin Film Incorporated with β-Cyclodextrin-Thymol Inclusion Complexes. Food Bioprocess Technol 11, 1695–1702 (2018). https://doi.org/10.1007/s11947-018-2134-1

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  • DOI: https://doi.org/10.1007/s11947-018-2134-1

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