Opinion statement
Performing endoscopic procedures in the elderly carries known enhanced risk compared to the general population. Weighing the benefits against the risks is easy when a patient is in immediate danger, but a gray area arises in screening protocols in an elderly patient of average risk. In this review, we compare national and international guidelines in average risk screening procedures (colonoscopic colorectal screening, Barrett’s surveillance) to find consensus for screening practice in the elderly. With minor differences between societal guidelines, it is widely agreed that 75 years is the appropriate age to begin to weigh risks and benefits according to a patient’s state of health and comorbidities. For colorectal screening, most guidelines advocate complete cessation of screening after the age of 85 years. Such consensus must take into account an aging population where patients are living healthier for longer and thus may be appropriate candidates for screening procedures even if beyond designated ages of screening cessation.
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References and Recommended Reading
Papers of particular interest, published recently, have been highlighted as: • Of importance
Adolph RJ. The elderly, the very elderly and traditional practice patterns. J Am Coll Cardiol. 1990;16(4):793–4.
Travis AC, Pievsky D, Saltzman JR. Endoscopy in the elderly. Am J Gastroenterol. 2012;107(10):1495–501. quiz 1494, 1502.
Stein HJ, Siewert JR. Barrett’s esophagus: pathogenesis, epidemiology, functional abnormalities, malignant degeneration, and surgical management. Dysphagia. 1993;8(3):276–88.
Cameron AJ, Souto EO, Smyrk TC. Small adenocarcinomas of the esophagogastric junction: association with intestinal metaplasia and dysplasia. Am J Gastroenterol. 2002;97(6):1375–80.
Portale G et al. Comparison of the clinical and histological characteristics and survival of distal esophageal-gastroesophageal junction adenocarcinoma in patients with and without barrett mucosa. Arch Surg. 2005;140(6):570–4. discussion 574-5.
Wang KK, Sampliner RE, G. Practice Parameters Committee of the American College of. Updated guidelines 2008 for the diagnosis, surveillance and therapy of Barrett’s esophagus. Am J Gastroenterol. 2008;103(3):788–97.
van der Burgh A et al. Oesophageal cancer is an uncommon cause of death in patients with Barrett’s oesophagus. Gut. 1996;39(1):5–8.
Cameron AJ et al. Adenocarcinoma of the esophagogastric junction and Barrett’s esophagus. Gastroenterology. 1995;109(5):1541–6.
Cameron AJ et al. Prevalence of columnar-lined (Barrett’s) esophagus. Comparison of population-based clinical and autopsy findings. Gastroenterology. 1990;99(4):918–22.
Hage M et al. Oesophageal cancer incidence and mortality in patients with long-segment Barrett’s oesophagus after a mean follow-up of 12.7 years. Scand J Gastroenterol. 2004;39(12):1175–9.
Sikkema M et al. Risk of esophageal adenocarcinoma and mortality in patients with Barrett’s esophagus: a systematic review and meta-analysis. Clin Gastroenterol Hepatol. 2010;8(3):235–44. quiz e32.
Conio M et al. Secular trends in the epidemiology and outcome of Barrett’s oesophagus in Olmsted County, Minnesota. Gut. 2001;48(3):304–9.
Csendes A et al. Prevalence of Barrett’s esophagus by endoscopy and histologic studies: a prospective evaluation of 306 control subjects and 376 patients with symptoms of gastroesophageal reflux. Dis Esophagus. 2000;13(1):5–11.
Hvid-Jensen F et al. Incidence of adenocarcinoma among patients with Barrett’s esophagus. N Engl J Med. 2011;365(15):1375–83.
Caygill CP et al. A single centre’s 20 years’ experience of columnar-lined (Barrett’s) oesophagus diagnosis. Eur J Gastroenterol Hepatol. 1999;11(12):1355–8.
Yousef F et al. The incidence of esophageal cancer and high-grade dysplasia in Barrett’s esophagus: a systematic review and meta-analysis. Am J Epidemiol. 2008;168(3):237–49.
Armstrong D et al. Canadian Consensus Conference on the management of gastroesophageal reflux disease in adults—update 2004. Can J Gastroenterol. 2005;19(1):15–35.
American Gastroenterological A et al. American Gastroenterological Association medical position statement on the management of Barrett’s esophagus. Gastroenterology. 2011;140(3):1084–91.
Boyer J et al. French Society of Digestive Endoscopy SFED guideline: monitoring of patients with Barrett’s esophagus. Endoscopy. 2007;39(9):840–2.
Hirota WK et al. ASGE guideline: the role of endoscopy in the surveillance of premalignant conditions of the upper GI tract. Gastrointest Endosc. 2006;63(4):570–80.
Committee, A.S.o.P. et al. The role of endoscopy in Barrett’s esophagus and other premalignant conditions of the esophagus. Gastrointest Endosc. 2012;76(6):1087–94.
Fitzgerald RC et al. British Society of Gastroenterology guidelines on the diagnosis and management of Barrett’s oesophagus. Gut. 2014;63(1):7–42. Most recent guidelines from the British Society of Gastroenterology.
Sharma P et al. Quality indicators for the management of Barrett’s esophagus, dysplasia, and esophageal adenocarcinoma: international consensus recommendations from the American Gastroenterological Association Symposium. Gastroenterology. 2015;149(6):1599–606. Most recent guidelines from the American Gastroenterological Association.
Ladas SD et al. Ethical issues in endoscopy: patient satisfaction, safety in elderly patients, palliation, and relations with industry. Second European Symposium on Ethics in Gastroenterology and Digestive Endoscopy, Kos, Greece, July 2006. Endoscopy. 2007;39(6):556–65.
Committee, A.S.o.P. et al. Modifications in endoscopic practice for the elderly. Gastrointest Endosc. 2013;78(1):1–7.
Theocharis GJ et al. Acute upper gastrointestinal bleeding in octogenarians: clinical outcome and factors related to mortality. World J Gastroenterol. 2008;14(25):4047–53.
Van Kouwen MC et al. Upper gastrointestinal endoscopy in patients aged 85 years or more. Results of a feasibility study in a district general hospital. Arch Gerontol Geriatr. 2003;37(1):45–50.
Seinela L et al. Reasons for and outcome of upper gastrointestinal endoscopy in patients aged 85 years or more: retrospective study. BMJ. 1998;317(7158):575–80.
Clarke GA et al. The indications, utilization and safety of gastrointestinal endoscopy in an extremely elderly patient cohort. Endoscopy. 2001;33(7):580–4.
Lee TC et al. Age is not a discriminating factor for outcomes of therapeutic upper gastrointestinal endoscopy. Hepatogastroenterology. 2007;54(77):1319–22.
Lockhart SP et al. Upper gastrointestinal endoscopy in the elderly. Br Med J (Clin Res Ed). 1985;290(6464):283.
Muravchick S. The elderly outpatient: current anesthetic implications. Curr Opin Anaesthesiol. 2002;15(6):621–5.
Abraham NS et al. Sedation versus no sedation in the performance of diagnostic upper gastrointestinal endoscopy: a Canadian randomized controlled cost-outcome study. Am J Gastroenterol. 2004;99(9):1692–9.
Carey EJ, Sorbi D. Unsedated endoscopy. Gastrointest Endosc Clin N Am. 2004;14(2):369–83.
Dumortier J et al. Unsedated transnasal EGD in daily practice: results with 1100 consecutive patients. Gastrointest Endosc. 2003;57(2):198–204.
Garcia RT et al. Unsedated ultrathin EGD is well accepted when compared with conventional sedated EGD: a multicenter randomized trial. Gastroenterology. 2003;125(6):1606–12.
Howlander N. SEER cancer statistics review, 1975–2012. Bethesda: National Cancer Institute; 2015.
Harewood GC, Lawlor GO. Incident rates of colonic neoplasia according to age and gender: implications for surveillance colonoscopy intervals. J Clin Gastroenterol. 2005;39(10):894–9.
Harewood GC, Lawlor GO, Larson MV. Incident rates of colonic neoplasia in older patients: when should we stop screening? J Gastroenterol Hepatol. 2006;21(6):1021–5.
Maheshwari S, Patel T, Patel P. Screening for colorectal cancer in elderly persons: who should we screen and when can we stop? J Aging Health. 2008;20(1):126–39.
Kahi CJ et al. Survival of elderly persons undergoing colonoscopy: implications for colorectal cancer screening and surveillance. Gastrointest Endosc. 2007;66(3):544–50.
Ko CW, Sonnenberg A. Comparing risks and benefits of colorectal cancer screening in elderly patients. Gastroenterology. 2005;129(4):1163–70.
Day LW, Velayos F. Colorectal cancer screening and surveillance in the elderly: updates and controversies. Gut Liver. 2015;9(2):143–51.
Lee DW et al. Patient-controlled sedation versus intravenous sedation for colonoscopy in elderly patients: a prospective randomized controlled trial. Gastrointest Endosc. 2002;56(5):629–32.
Wilson JA. Colon cancer screening in the elderly: when do we stop? Trans Am Clin Climatol Assoc. 2010;121:94–103.
Romero RV, Mahadeva S. Factors influencing quality of bowel preparation for colonoscopy. World J Gastrointest Endosc. 2013;5(2):39–46.
Inadomi JM, Sonnenberg A. The impact of colorectal cancer screening on life expectancy. Gastrointest Endosc. 2000;51(5):517–23.
Terret C et al. Effects of comorbidity on screening and early diagnosis of cancer in elderly people. Lancet Oncol. 2009;10(1):80–7.
Lieberman DA et al. Guidelines for colonoscopy surveillance after screening and polypectomy: a consensus update by the US Multi-Society Task Force on Colorectal Cancer. Gastroenterology. 2012;143(3):844–57.
Cairns SR et al. Guidelines for colorectal cancer screening and surveillance in moderate and high risk groups (update from 2002). Gut. 2010;59(5):666–89.
Qaseem A et al. Screening for colorectal cancer: a guidance statement from the American College of Physicians. Ann Intern Med. 2012;156(5):378–86.
Care, C.T.F.o.P.H. Recommendations on screening for colorectal cancer in primary care. CMAJ. 2016;188(5):340–8.
Leddin DJ et al. Canadian Association of Gastroenterology position statement on screening individuals at average risk for developing colorectal cancer: 2010. Can J Gastroenterol. 2010;24(12):705–14.
von Karsa L, Patnick J, Segnan N. European guidelines for quality assurance in colorectal cancer screening and diagnosis. First Edition—Executive summary. Endoscopy. 2012;44 Suppl 3:SE1–8.
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Rita Abdelmessih, Christopher D. Packey, and Garrett Lawlor declare that they have no conflict of interest.
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This article is part of the Topical Collection on Intractable Disease in the Elderly: When Conventional Therapy Fails
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Abdelmessih, R., Packey, C.D. & Lawlor, G. Endoscopy in the Elderly: a Cautionary Approach, When to Stop. Curr Treat Options Gastro 14, 305–314 (2016). https://doi.org/10.1007/s11938-016-0101-3
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DOI: https://doi.org/10.1007/s11938-016-0101-3