Skip to main content
Log in

Atrial Fibrillation Management in Heart Failure: Interrupting the Vicious Cycle

  • Arrhythmia (R Kabra, Section Editor)
  • Published:
Current Treatment Options in Cardiovascular Medicine Aims and scope Submit manuscript

Abstract

Purpose of review

In this review article, we aim to describe the pathophysiology of concomitant atrial fibrillation and both left and right heart failure, as well as pronounce the prognosis of having these two conditions simultaneously. This review also summarizes the current management of atrial fibrillation including stroke and thromboembolism prevention in the presence of systolic and diastolic heart failure.

Recent findings

While rhythm control strategy is not superior to rate control strategy in atrial fibrillation patients without heart failure, catheter ablation for atrial fibrillation has shown to improve outcomes in patients with coexisting heart failure.

Summary

Atrial fibrillation is the most common arrhythmia that frequently coexists with heart failure. The incidence of one condition increases in the presence of the other posing a significant treatment challenge. Despite ample advancement in management strategies of atrial fibrillation and heart failure, this combination is associated with higher morbidity and mortality when found in the same patient. The treatment goal in these patients is to improve quality of life by controlling symptoms and to prevent thromboembolism with appropriate anticoagulation. Catheter ablation is a promising treatment option for symptomatic patients with depressed ventricular function. Finally, pacing with cardiac resynchronization therapy after AV nodal ablation should be considered when strict control of ventricular rate is desired in atrial fibrillation patients who meet the criteria for device implantation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Similar content being viewed by others

References and Recommended Reading

Papers of particular interest, published recently, have been highlighted as: • Of importance

  1. Anter E, Jessup M, Callans DJ. AF and heart failure: treatment considerations for a dual epidemic. Circulation. 2009;119:2516–25. https://doi.org/10.1161/CIRCULATIONAHA.108.821306.

    Article  PubMed  Google Scholar 

  2. Stewart S, Hart CL, Hole DJ, McMurray JJV. A population-based study of the long term risks associated with AF: 20-year follow-up of the Renfrew/ Paisley study. Am J Med. 2002;113:359–64.

    Article  Google Scholar 

  3. Maisel WH, Stevenson LW. AF in heart failure: epidemiology, pathophysiology, and rationale for therapy. Am J Cardiol. 2003;91:2D–8D.

    Article  Google Scholar 

  4. Wang TJ, Larson MG, Levy D, Vasan RS, Leip EP, Wolf PA, et al. Temporal relations of AF and congestive heart failure and their joint influence on mortality: the Framingham Heart Study. Circulation. 2003;107:2920–5.

    Article  Google Scholar 

  5. Mamas MA, Caldwell JC, Chacko S, Garratt CJ, Fath-Ordoubadi F, Neyses L. A meta-analysis of the prognostic significance of AF in chronic heart failure. Eur J Heart Fail. 2009;11:676–83.

    Article  Google Scholar 

  6. Adams KF, Fonarow GC, Emerman CL, LeJemtel TH, Costanzo MR, Abraham WT, et al. Characteristics and outcomes of patients hospitalized for heart failure in the United States:rationale, design, and preliminary observations from the first 100,000 cases in the Acute Decompensated Heart Failure National Registry (ADHERE). Am Heart J. 2005;149:209–16.

    Article  Google Scholar 

  7. Krum H, Gilbert RE. Demographics and concomitant disorders in heart failure. Lancet. 2003;362:147–58.

    Article  Google Scholar 

  8. Campbell RT, McMurray JJV. Comorbidities and differential diagnosis in heart failure with preserved ejection fraction. Heart Fail Clin. 2014;10(3):481–501.

    Article  Google Scholar 

  9. Zakeri R, Chamberlain AM, Roger VL, Redfield MM. temporal relationship and prognostic significance of af in heart failure patients with preserved ejection fraction a community-based study. Circulation. 2013;128(10):1085–93.

    Article  Google Scholar 

  10. Santhanakrishnan E, Wang N, Larson MG, Magnani JW, McManus DD, Lubitz SA, et al. AF begets heart failure and vice versa. Circulation. 2016;133(5):484–92.

    Article  Google Scholar 

  11. Sartipy U, Dahlström U, Fu M, Lund LH. AF in heart failure with preserved, mid-range, and reduced ejection fraction. JACC Heart Fail. 2017;5(8):565–74.

    Article  Google Scholar 

  12. Deedwania PC, Lardizabal JA. AF in heart failure: a comprehensive review. Am J Med. 2010;123:198–204.

    Article  Google Scholar 

  13. Wasmund SL, Li JM, Page RL, Joglar JA, Kowal RC, Smith ML, et al. Effect of AF and an irregular ventricular response on sympathetic nerve activity in human subjects. Circulation. 2003;107:2011–5. https://doi.org/10.1161/01.CIR.0000064900.76674.CC.

    Article  PubMed  Google Scholar 

  14. Byrne M, Kaye DM, Power J. The synergism between AF and heart failure. J Card Fail. 2008;14:320–6. https://doi.org/10.1016/j.cardfail.2007.12.005.

    Article  PubMed  Google Scholar 

  15. Tuinenburg AE, Van Veldhuisen DJ, Boomsma F, Van Den Berg MP, De Kam PJ, Crijns HJ. Comparison of plasma neurohormones in congestive heart failure patients with AF versus patients with sinus rhythm. Am J Cardiol. 1998;81:1207–10.

    Article  CAS  Google Scholar 

  16. Nerheim P, Birger-Botkin S, Piracha L, Olshansky B. Heart failure and sudden death in patients with tachycardia-induced cardiomyopathy and recurrent tachycardia. Circulation. 2004;110:247–52.

    Article  Google Scholar 

  17. Raymond RJ, Lee AJ, Messineo FC, Manning WJ, Silverman DI. Cardiac performance early after cardioversion from AF. Am Heart J. 1998;136:435–42.

    Article  CAS  Google Scholar 

  18. Li D, Shinagawa K, Pang L, Leung TK, Cardin S, Wang Z, et al. Effects of angiotensin-converting enzyme inhibition on the development of the AF substrate in dogs with ventricular tachypacing-induced congestive heart failure. Circulation. 2001;104:2608–14.

    Article  CAS  Google Scholar 

  19. Li D, Fareh S, Leung TK, Nattel S. Promotion of AF by heart failure in dogs: atrial remodeling of a different sort. Circulation. 1999;100:87–95.

    Article  CAS  Google Scholar 

  20. Cha YM, Dzeja PP, Shen WK, Jahangir A, Hart CY, Terzic A, et al. Failing atrial myocardium: energetic deficits accompany structural remodeling and electrical instability. Am J Physiol Heart Circ Physiol. 2003;284:H1313–20.

    Article  CAS  Google Scholar 

  21. Olsson LG, Swedberg K, Ducharme A, Granger CB, Michelson EL, McMurray JJV, et al. CHARM investigators. af and risk of clinical events in chronic heart failure with and without left ventricular systolic dysfunction. J Am Coll Cardiol. 2006;47(10):1997–2004.

    Article  Google Scholar 

  22. Kotecha D, Chudasama R, Lane DA, Kirchhof P, Lip GY. AF and heart failure due to reduced versus preserved ejection fraction: A systematic review and meta-analysis of death and adverse outcomes. Int J Cardiol. 2016;203:660–6.

    Article  Google Scholar 

  23. Kim TH, Shim CY, Park JH, Nam CM, Uhm JS, Joung B, et al. Left ventricular diastolic dysfunction is associated with atrial remodeling and risk or presence of stroke in patients with paroxysmal AF. J Cardiol. 2016;68(2):104–9.

    Article  Google Scholar 

  24. Demirçelik MB, Çetin M, Çiçekcioğlu H, Uçar Ö, Duran M. Effect of left ventricular diastolic dysfunction on left atrial appendage function and thrombotic potential in nonvalvular AF. Anadolu Kardiyol Derg. 2014;14(3):256–60.

    Article  Google Scholar 

  25. Coromilas J. Obesity and AF: is one epidemic feeding the other? JAMA. 2004;292:2519–20. https://doi.org/10.1001/jama.292.20.2519.

    Article  CAS  PubMed  Google Scholar 

  26. Wang TJ, Parise H, Levy D, D’Agostino RB Sr, Wolf PA, Vasan RS, et al. Obesity and the risk of new-onset AF. JAMA. 2004;292:2471–7. https://doi.org/10.1001/jama.292.20.2471.

    Article  CAS  PubMed  Google Scholar 

  27. Pathak RK, Middeldorp ME, Meredith M, Mehta AB, Mahajan R, Wong CX, et al. Long-term effect of goal-directed weight management in an AF cohort: a long-term follow-up study (LEGACY). J Am Coll Cardiol. 2015;65:2159–69. https://doi.org/10.1016/j.jacc.2015.03.002.

    Article  PubMed  Google Scholar 

  28. Abed HS, Wittert GA, Leong DP, Shirazi MG, Bahrami B, Middeldorp ME, et al. Effect of weight reduction and cardio metabolic risk factor management on symptom burden and severity in patients with AF: A randomized clinical trial. JAMA. 2013;310:2050–60. https://doi.org/10.1001/jama.2013.280521.

    Article  CAS  PubMed  Google Scholar 

  29. Lavie CJ, Alpert MA, Arena R, Mehra MR, Milani RV, Ventura HO. Impact of obesity and the obesity paradox on prevalence and prognosis in heart failure. JACC Heart Fail. 2013;1:93–102. https://doi.org/10.1016/j.jchf.2013.01.006.

    Article  PubMed  Google Scholar 

  30. Clark AL, Fonarow GC, Horwich TB. Obesity and the obesity paradox in heart failure. Prog Cardiovasc Dis. 2014;56:409–14. https://doi.org/10.1016/j.pcad.2013.10.004.

    Article  PubMed  Google Scholar 

  31. Alpert MA, Omran J, Mehra A, Ardhanari S. Impact of obesity and weight loss on cardiac performance and morphology in adults. Prog Cardiovasc Dis. 2014;56:391–400. https://doi.org/10.1016/j.pcad.2013.09.003.

    Article  PubMed  Google Scholar 

  32. Kenchaiah S, Evans JC, Levy D, Wilson PW, Benjamin EJ, Larson MG, et al. Obesity and the risk of heart failure. N Engl J Med. 2002;347:305–13. https://doi.org/10.1056/NEJMoa020245.

    Article  PubMed  Google Scholar 

  33. Hays AG, Sacco RL, Rundek T, Sciacca RR, Jin Z, Liu R, et al. Left ventricular systolic dysfunction and the risk of ischemic stroke in a multiethnic population. Stroke. 2006;37:1715–9.

    Article  Google Scholar 

  34. Agarwal M, Apostolakis S, Lane DA, Lip GY. The impact of heart failure and left ventricular dysfunction in predicting stroke, thromboembolism, and mortality in AF patients: a systematic review. Clin Ther. 2014;36:1135–44.

    Article  Google Scholar 

  35. McMurray JJ, Ezekowitz JA, Lewis BS, Gersh BJ, van Diepen S, Amerena J, et al. Left ventricular systolic dysfunction, heart failure, and the risk of stroke and systemic embolism in patients with AF: insights from the ARISTOTLE trial. Circ Heart Fail. 2013;6:451–60. https://doi.org/10.1161/CIRCHEARTFAILURE.112.000143.

    Article  CAS  PubMed  Google Scholar 

  36. Ferreira J, Ezekowitz MD, Connolly SJ, Brueckmann M, Fraessdorf M, Reilly PA, et al. Dabigatran compared with warfarin in patients with AF and symptomatic heart failure: a subgroup analysis of the RE-LY trial. Eur J Heart Fail. 2013;15:1053–61. https://doi.org/10.1093/eurjhf/hft111.

    Article  CAS  PubMed  Google Scholar 

  37. Contreras JP, Hong KN, Castillo J, et al. Anticoagulation in patients with AF and heart failure: Insights from the NCDR PINNACLE-AF registry. Clin Cardiol. 2019;42:339–45.

    Article  Google Scholar 

  38. January CT, Wann LS, Alpert JS, et al. 2014 AHA/ACC/HRS guideline for the management of patients with AF: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society. J Am Coll Cardiol. 2014;64:e1–76.

    Article  Google Scholar 

  39. Kotecha D, Holmes J, Krum H, et al. Efficacy of beta blockers in patients with heart failure plus AF: an individual-patient data meta analysis. Lancet. 2014;384:2235–43.

    Article  CAS  Google Scholar 

  40. Carlisle MA, Fudim M, DeVore AD, Piccini JP. Heart failure and af, like fire and fury. JACC Heart Fail. 2019;7(6):447–56.

    Article  Google Scholar 

  41. Ouyang A-J, Lv Y-N, Zhong H-L, Wen J-H, Wei X-H, Peng H-W, et al. Meta-analysis of digoxin use and risk of mortality in patients with AF. Am J Cardiol. 2015. https://doi.org/10.1016/j.amjcard.2015.01.013.

  42. Vamos M, Erath JW, Hohnloser SH. Digoxin-associated mortality: a systematic review and meta-analysis of the literature. Eur Heart J. 2015;36(28):1831–8. https://doi.org/10.1093/eurheartj/ehv143.

    Article  CAS  PubMed  Google Scholar 

  43. Chamaria S, Desai AM, Reddy PC, Olshansky B, Dominic P. Digoxin use to control ventricular rate in patients with af and heart failure is not associated with increased mortality. Cardiol Res Pract. 2015;2015(8):314041–10. https://doi.org/10.1155/2015/314041.

    Article  PubMed  PubMed Central  Google Scholar 

  44. Patel NJ, Hoosien M, Deshmukh A, Badheka AO, Grover PM, Shah N, et al. Digoxin significantly improves all-cause mortality in AF patients with severely reduced left ventricular systolic function. Int J Cardiol. 2013;169(5):e84–6.

    Article  Google Scholar 

  45. Mina GS, Acharya M, Shepherd T, Gobrial G, Tekeste M, Watti H, et al. digoxin is associated with increased shock events and electrical storms in patients with implantable cardioverter defibrillators. J Cardiovasc Pharmacol Ther. 2017;47(3):107424841773241–7. https://doi.org/10.1177/1074248417732416.

    Article  CAS  Google Scholar 

  46. Di Biase L, Mohanty P, Mohanty S, et al. Ablation versus amiodarone for treatment of persistent AF in patients with congestive heart failure and an implanted device: results from the AATAC Multicenter RandomizedTrial. Circulation. 2016;133:1637–44.

    Article  Google Scholar 

  47. Marrouche NF, Brachmann J, Andresen D, et al. Catheter ablation for AF with heart failure. N Engl J Med. 2018;378:417–27. Marrouche NF et al 2018- is a landmark trial that clearly established Catheter ablation as offering mortality benefit over medical management in patients with heart failure with reduced ejection fraction paving way for the updated guidelines on Afib management.

  48. Jones DG, Haldar SK, Hussain W, et al. A randomized trial to assess catheter ablation versus rate control in the management of persistent AF in heart failure. J Am Coll Cardiol. 2013;61:1894–903.

    Article  Google Scholar 

  49. Hunter RJ, Berriman TJ, Diab I, Kamdar R, Richmond L, Baker V, et al. A randomized controlled trial of catheter ablation versus medical treatment of AF in heart failure (the CAMTAF trial). Circ Arrhythm Electrophysiol. 2014;7(1):31–8.

    Article  CAS  Google Scholar 

  50. Packer DL, Mark DB, Robb RA, Monahan K, Bahnson T, Moretz K, et al. Catheter ablation versus antiarrhythmic drug therapy for AF (CABANA) Trial: study rationale and design. Am Heart J. 2018;199:192–9.

    Article  Google Scholar 

  51. Khan MN, Jais P, Cummings J, et al. Pulmonary-vein isolation for AF in patients with heart failure. N Engl J Med. 2008;359:1778–85.

    Article  CAS  Google Scholar 

  52. Freudenberger RS, Wilson AC, Kostis JB. comparison of rate versus rhythm control for AF in patients with left ventricular dysfunction (from the AFFIRM Study). Am J Cardiol. 2007;100(2):247–52. https://doi.org/10.1016/j.amjcard.2007.02.101.

    Article  PubMed  Google Scholar 

  53. Roy D, Talajic M, Nattel S. on behalf of the AF and Congestive Heart Failure Investigators, et al. Rhythm control versus rate control for AF and heart failure. N Engl J Med. 2008;358:2667–77.

    Article  CAS  Google Scholar 

  54. Shelton RJ, Clark AL, Goode K, et al. A randomised, controlled study of rate versus rhythm control in patients with chronic AF and heart failure: (CAFE-II Study). Heart. 2009;95(11):924–30. https://doi.org/10.1136/hrt.2008.158931.

    Article  CAS  PubMed  Google Scholar 

  55. Young JB, Dunlap ME, Pfeffer MA. et al. Mortality and morbidity reduction with Candesartan in patients with chronic heart failure and left ventricular systolic dysfunction: results of the CHARM low-left ventricular ejection fraction trials. Circulation. 110:2618–26.

  56. Daoud EG, Weiss R, Bahu M. et al. Effect of an irregular ventricular rhythm on cardiac output. Am J Cardiol. 78:1433–6.

  57. McAlister FA, Ezekowitz JA, Wiebe N, et al. Systematic review: cardiac resynchronization in patients with symptomatic heart failure. Ann Intern Med. 141:381–90.

  58. Mustafa U, Atkins J, Mina G, et al. Outcomes of cardiac resynchronisation therapy in patients with heart failure with atrial fibrillation: a systematic review and meta-analysis of observational studies. Open Heart. 2019;6(1):e000937. https://doi.org/10.1136/openhrt-2018-000937. Mustafa U et al 2019 and Reference 68, Mustafa et al 2018, These two meta-analyses present the conundrum of device therapy in patients with heart failure and atrial fibrillation and offer insights into possible solutions.

  59. Eisen A, Nevzorov R, Goldenberg G, et al. Cardiac resynchronization therapy in patients with AF: A 2-year follow-up study. Pacing Clin Electrophysiol. 36:872–7.

  60. Tolosana JM, Arnau AM, Madrid AH, et al. Cardiac resynchronization therapy in patients with permanent AF. Is it mandatory to ablate the atrioventricular junction to obtain a good response? Eur J Heart Fail. 14:635–41.

  61. Tolosana JM, Hernandez Madrid A, Brugada J, et al. Comparison of benefits and mortality in cardiac resynchronization therapy in patients with af versus patients in sinus rhythm (Results of the Spanish AF and Resynchronization [SPARE] Study). Am J Cardiol. 102:444–9.

  62. Molhoek SG, Bax JJ, Bleeker GB, et al. Comparison of response to cardiac resynchronization therapy in patients with sinus rhythm versus chronic AF. Am J Cardiol. 94:1506–9.

  63. Luedorff G, Grove R, Kowalski M, et al. Chronisches Vorhofflimmern bei schwerer Herzinsuffizienz und CRT-Indikation. Herzschrittmacherther Elektrophysiol. 22:226–32.

  64. Delnoy PPHM, Ottervanger JP, Luttikhuis HO, et al. Comparison of usefulness of cardiac resynchronization therapy in patients with af and heart failure versus patients with sinus rhythm and heart failure. Am J Cardiol. 99:1252–7.

  65. Boven NV, Theuns D, Bogaard K, et al. AF in cardiac resynchronization therapy with a defibrillator: a risk factor for mortality, appropriate and inappropriate shocks. J Cardiovasc Electrophysiol. 32:n/a–a.

  66. Gasparini M, Auricchio A, Regoli F, et al. Four-year efficacy of cardiac resynchronization therapy on exercise tolerance and disease progression. J Am Coll Cardiol. 48:734–43.

  67. Gasparini M, Leclercq C, Heart MLJ, et al. Cardiac resynchronization therapy in patients with AF: the CERTIFY study Cardiac Resynchronization Therapy in AF Patients Multinational. Heartfailureonlinejaccorg

  68. Jędrzejczyk-Patej E, Lenarczyk R, Pruszkowska P, et al. Long-term outcomes of cardiac resynchronization therapy are worse in patients who require atrioventricular junction ablation for AF than in those with sinus rhythm. Cardiol J. 21:309–15.

  69. Dong K, Shen W-K, Powell BD, et al. Atrioventricular nodal ablation predicts survival benefit in patients with AF receiving cardiac resynchronization therapy. Heart Rhythm. 7:1240–5.

  70. Hayes DL, Boehmer JP, Day JD, et al. Cardiac resynchronization therapy and the relationship of percent biventricular pacing to symptoms and survival. Heart Rhythm. 8:1469–75.

  71. Yancy CW, Jessup M, Bozkurt B, et al. ACCF/AHA Guideline for the Management of Heart Failure. Circulation. 2013;128:e283.

    Google Scholar 

  72. Mustafa U, Dherange P, Reddy R, et al. Atrial fibrillation is associated with higher overall mortality in patients with implantable cardioverter-defibrillator: a systematic review and meta-analysis. J Am Heart Assoc. 2018;7(22):e010156. https://doi.org/10.1161/JAHA.118.010156.

    Article  PubMed  PubMed Central  Google Scholar 

  73. Moss AJ, Schuger C, Beck CA, et al. Reduction in inappropriate therapy and mortality through ICD programming. Mass Medical Soc. 367:2275–83.

  74. Borleffs CJW, Ypenburg C, van Bommel RJ, et al. Clinical importance of new-onset AF after cardiac resynchronization therapy. Heart Rhythm. 6:305–10.

  75. Deneke T, Lawo T, Gerritse B, et al. Mortality of patients with implanted cardioverter/defibrillators in relation to episodes of AF. Europace. 6:151–8.

  76. van Gelder IC, PHAN HM, Wilkoff BL, et al. Prognostic significance of atrial arrhythmias in a primary prevention ICD population. Pacing Clin Electrophysiol. 34:1070–9.

  77. Köbe J, Wasmer K, Andresen D, et al. Impact of AF on early complications and one year-survival after cardioverter defibrillator implantation: Results from the German DEVICE registry. Int J Cardiol. 168:4184–90.

  78. Zareba W, Steinberg JS, McNitt S, et al. Implantable cardioverter-defibrillator therapy and risk of congestive heart failure or death in MADIT II patients with AF:3, 631–Heart Rhythm, 637.

  79. Bunch TJ, Day JD, Olshansky B, et al. Newly detected AF in patients with an implantable cardioverter-defibrillator is a strong risk marker of increased mortality. Heart Rhythm. 6:2–8.

  80. Schernthaner C, Pichler M, Strohmer B. Lower body mass index and AF as independent predictors for mortality in patients with implantable cardioverter defibrillator. Croat Med J. 48:59–67.

  81. Olsson KM, Nickel NP, Tongers J, Hoeper MM. Atrial flutter and fibrillation in patients with pulmonary hypertension.internationaljournalofcardiology.com. https://www.internationaljournalofcardiology.com/article/S0167-5273(12)00799-1/pdf. Published June 22, 2013.

  82. Mojadidi MK, Caceras JD, Eshtehardi P, Pamerla M, Mannem S, Zolty R. AF results in higher mortality in patients with pulmonary hypertension. JAC. 2019;63(12 Supplement):A367. https://doi.org/10.1016/S0735-1097(14)60367-3.

    Article  Google Scholar 

  83. Tongers J, Schwerdtfeger B, Klein G, et al. Incidence and clinical relevance of supraventricular tachyarrhythmias in pulmonary hypertension. Am Heart J. 2007;153(1):127–32. https://doi.org/10.1016/j.ahj.2006.09.008.

    Article  PubMed  Google Scholar 

Download references

Funding

This work was supported by the National Institutes of Health National Institutes of Health grants (NIGMS 5 P20 GM121307–02 Center for Redox Biology and Cardiovascular Disease).

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Paari Dominic MD.

Ethics declarations

Conflict of Interest

Tina Firouzbakht declares that she has no conflict of interest. Usman Mustafa declares that he has no conflict of interest. Sania Jiwani declares that she has no conflict of interest. Paari Dominic declares that he has no conflict of interest.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This article is part of the Topical Collection on Arrhythmia

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Firouzbakht, T., Mustafa, U., Jiwani, S. et al. Atrial Fibrillation Management in Heart Failure: Interrupting the Vicious Cycle. Curr Treat Options Cardio Med 22, 12 (2020). https://doi.org/10.1007/s11936-020-00812-2

Download citation

  • Published:

  • DOI: https://doi.org/10.1007/s11936-020-00812-2

Keywords

Navigation