Skip to main content

Advertisement

Log in

Approach to Management of Premature Ventricular Contractions

  • Arrhythmia (R Kabra, Section Editor)
  • Published:
Current Treatment Options in Cardiovascular Medicine Aims and scope Submit manuscript

Abstract

Purpose of review

Premature ventricular contractions (PVCs) are arrhythmias with presentation ranging from asymptomatic and benign to symptomatic, frequent and capable of inducing cardiomyopathy. Work in the late 1970s–1980s showed that they could be representative of underlying coronary artery disease, hypertension, or left ventricular hypertrophy. Furthermore, their presence is independently linked to an increased risk of stroke and sudden cardiac death. Since characterization of PVC-induced cardiomyopathy 21 years ago, there has been progressive interest in treating PVCs. This review aims to present an approach that practitioners can use for the treatment of PVCs.

Recent findings

Recent efforts have focused on optimizing techniques for mapping and ablation of PVCs in patients with symptoms or reduced LVEF. However, an understanding of the medical treatment options is necessary because medical management is still the first line of therapy. The practitioner will need to weigh the risks and benefits of these strategies in order to help the patient determine the best course of action.

Summary

PVCs are recognized as a clinically significant arrhythmia, and evolving treatment strategies can improve cardiovascular outcomes. This review provides a concise summary of the current state of PVC treatment.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig 1

Similar content being viewed by others

References and Recommended Reading

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Simpson RJ Jr, Cascio WE, Crow RS, Schreiner PJ, Rautaharju PM, Heiss G. Association of ventricular premature complexes with electrocardiographic-estimated left ventricular mass in a population of African-American and white men and women (the atherosclerosis risk in communities). Am J Cardiol. 2001;87(1):49–53.

    Article  Google Scholar 

  2. Ribeiro WN, Yamada AT, Grupi CJ, da Silva GT, Mansur AJ. Premature atrial and ventricular complexes in outpatients referred from a primary care facility. PLoS One. 2018;13(9):e0204246. https://doi.org/10.1371/journal.pone.0204246.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Brodsky M, Wu D, Denes P, Kanakis C, Rosen KM. Arrhythmias documented by 24 hour continuous electrocardiographic monitoring in 50 male medical students without apparent heart disease. Am J Cardiol. 1977;39(3):390–5.

    Article  CAS  Google Scholar 

  4. Lee GK, Klarich KW, Grogan M, Cha YM. Premature ventricular contraction-induced cardiomyopathy: a treatable condition. Circ Arrhythm Electrophysiol. 2012;5(1):229–36. https://doi.org/10.1161/CIRCEP.111.963348.

    Article  PubMed  Google Scholar 

  5. •• Al-Khatib SM, Stevenson WG, Ackerman MJ, Bryant WJ, Callans DJ, Curtis AB, et al. 2017 AHA/ACC/HRS guideline for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society. Heart Rhythm. 2018;15(10):e190–252. https://doi.org/10.1016/j.hrthm.2017.10.035. Guidelines from 2017 written by AHA/ACC/HRS for medical and invasive therapy of ventricular arrhythmias.

    Article  PubMed  Google Scholar 

  6. Abdalla IS, Prineas RJ, Neaton JD, Jacobs DR Jr, Crow RS. Relation between ventricular premature complexes and sudden cardiac death in apparently healthy men. Am J Cardiol. 1987;60(13):1036–42.

    Article  CAS  Google Scholar 

  7. Massing MW, Simpson RJ Jr, Rautaharju PM, Schreiner PJ, Crow R, Heiss G. Usefulness of ventricular premature complexes to predict coronary heart disease events and mortality (from the Atherosclerosis Risk In Communities cohort). Am J Cardiol. 2006;98(12):1609–12. https://doi.org/10.1016/j.amjcard.2006.06.061.

    Article  PubMed  Google Scholar 

  8. Simpson RJ Jr, Cascio WE, Schreiner PJ, Crow RS, Rautaharju PM, Heiss G. Prevalence of premature ventricular contractions in a population of African American and white men and women: the Atherosclerosis Risk in Communities (ARIC) study. Am Heart J. 2002;143(3):535–40.

    Article  Google Scholar 

  9. Ofoma U, He F, Shaffer ML, Naccarelli GV, Liao D. Premature cardiac contractions and risk of incident ischemic stroke. J Am Heart Assoc. 2012;1(5):e002519. https://doi.org/10.1161/JAHA.112.002519.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Duffee DF, Shen WK, Smith HC. Suppression of frequent premature ventricular contractions and improvement of left ventricular function in patients with presumed idiopathic dilated cardiomyopathy. Mayo Clin Proc. 1998;73(5):430–3. https://doi.org/10.1016/S0025-6196(11)63724-5.

    Article  CAS  PubMed  Google Scholar 

  11. Sarrazin JF, Labounty T, Kuhne M, Crawford T, Armstrong WF, Desjardins B, et al. Impact of radiofrequency ablation of frequent post-infarction premature ventricular complexes on left ventricular ejection fraction. Heart Rhythm. 2009;6(11):1543–9. https://doi.org/10.1016/j.hrthm.2009.08.004.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Singh SN, Fletcher RD, Fisher SG, Singh BN, Lewis HD, Deedwania PC, et al. Amiodarone in patients with congestive heart failure and asymptomatic ventricular arrhythmia. Survival trial of antiarrhythmic therapy in congestive heart failure. N Engl J Med. 1995;333(2):77–82. https://doi.org/10.1056/NEJM199507133330201.

    Article  CAS  PubMed  Google Scholar 

  13. Niwano S, Wakisaka Y, Niwano H, Fukaya H, Kurokawa S, Kiryu M, et al. Prognostic significance of frequent premature ventricular contractions originating from the ventricular outflow tract in patients with normal left ventricular function. Heart. 2009;95(15):1230–7. https://doi.org/10.1136/hrt.2008.159558.

    Article  CAS  PubMed  Google Scholar 

  14. Del Carpio MF, Syed FF, Noheria A, Cha YM, Friedman PA, Hammill SC, et al. Characteristics of premature ventricular complexes as correlates of reduced left ventricular systolic function: study of the burden, duration, coupling interval, morphology and site of origin of PVCs. J Cardiovasc Electrophysiol. 2011;22(7):791–8. https://doi.org/10.1111/j.1540-8167.2011.02021.x.

    Article  Google Scholar 

  15. Tan AY, Hu YL, Potfay J, Kaszala K, Howren M, Sima AP, et al. Impact of ventricular ectopic burden in a premature ventricular contraction-induced cardiomyopathy animal model. Heart Rhythm. 2016;13(3):755–61. https://doi.org/10.1016/j.hrthm.2015.11.016.

    Article  PubMed  Google Scholar 

  16. Potfay J, Kaszala K, Tan AY, Sima AP, Gorcsan J 3rd, Ellenbogen KA, et al. Abnormal left ventricular mechanics of ventricular ectopic beats: insights into origin and coupling interval in premature ventricular contraction-induced cardiomyopathy. Circ Arrhythm Electrophysiol. 2015;8(5):1194–200. https://doi.org/10.1161/CIRCEP.115.003047.

    Article  PubMed  PubMed Central  Google Scholar 

  17. Walters TE, Rahmutula D, Szilagyi J, Alhede C, Sievers R, Fang Q, et al. Left ventricular dyssynchrony predicts the cardiomyopathy associated with premature ventricular contractions. J Am Coll Cardiol. 2018;72(23 Pt A):2870–82. https://doi.org/10.1016/j.jacc.2018.09.059.

    Article  PubMed  Google Scholar 

  18. Capucci A, Di Pasquale G, Boriani G, Carini G, Balducelli M, Frabetti L, et al. A double-blind crossover comparison of flecainide and slow-release mexiletine in the treatment of stable premature ventricular complexes. Int J Clin Pharmacol Res. 1991;11(1):23–33.

    CAS  PubMed  Google Scholar 

  19. Zhong L, Lee YH, Huang XM, Asirvatham SJ, Shen WK, Friedman PA, et al. Relative efficacy of catheter ablation vs antiarrhythmic drugs in treating premature ventricular contractions: a single-center retrospective study. Heart Rhythm. 2014;11(2):187–93. https://doi.org/10.1016/j.hrthm.2013.10.033.

    Article  PubMed  Google Scholar 

  20. Schillaci G, Verdecchia P, Borgioni C, Ciucci A, Zampi I, Battistelli M, et al. Association between persistent pressure overload and ventricular arrhythmias in essential hypertension. Hypertension. 1996;28(2):284–9.

    Article  CAS  Google Scholar 

  21. Sultana R, Sultana N, Rashid A, Rasheed SZ, Ahmed M, Ishaq M, et al. Cardiac arrhythmias and left ventricular hypertrophy in systemic hypertension. J Ayub Med Coll Abbottabad. 2010;22(4):155–8.

    PubMed  Google Scholar 

  22. Kostis JB, Allen R, Berkson DM, Curb JD, Davey J, Grimm RH, et al. Correlates of ventricular ectopic activity in isolated systolic hypertension. SHEP cooperative research group. Am Heart J. 1994;127(1):112–21.

    Article  CAS  Google Scholar 

  23. Papademetriou V, Price M, Notargiacomo A, Gottdiener J, Fletcher RD, Freis ED. Effect of diuretic therapy on ventricular arrhythmias in hypertensive patients with or without left ventricular hypertrophy. Am Heart J. 1985;110(3):595–9.

    Article  CAS  Google Scholar 

  24. Ettinger PO, Wu CF, De La Cruz C Jr, Weisse AB, Ahmed SS, Regan TJ. Arrhythmias and the “holiday heart”: alcohol-associated cardiac rhythm disorders. Am Heart J. 1978;95(5):555–62.

    Article  CAS  Google Scholar 

  25. Sekizuka H, Miyake H. The relationship between premature ventricular contractions and lifestyle-related habits among the Japanese working population (FUJITSU cardiovascular and respiratory observational study-1; FACT-1). J Nippon Med Sch. 2018;85(6):337–42. https://doi.org/10.1272/jnms.JNMS.2018_85-55.

    Article  PubMed  Google Scholar 

  26. • Brunner S, Herbel R, Drobesch C, Peters A, Massberg S, Kaab S, et al. Alcohol consumption, sinus tachycardia, and cardiac arrhythmias at the Munich Octoberfest: results from the Munich Beer Related Electrocardiogram Workup Study (MunichBREW). Eur Heart J. 2017;38(27):2100–6. https://doi.org/10.1093/eurheartj/ehx156. Interesting trial design studying the effects on alcohol consumption on cardiac arrhythmias, utilizing patrons of the Munich Octoberfest.

    Article  PubMed  PubMed Central  Google Scholar 

  27. Kerola T, Dewland TA, Vittinghoff E, Heckbert SR, Stein PK, Marcus GM. Modifiable predictors of ventricular ectopy in the community. J Am Heart Assoc. 2018;7(22):e010078. https://doi.org/10.1161/JAHA.118.010078.

    Article  PubMed  PubMed Central  Google Scholar 

  28. Marinheiro R, Parreira L, Amador P, Mesquita D, Farinha J, Fonseca M, et al. Ventricular arrhythmias in patients with obstructive sleep apnea. Curr Cardiol Rev. 2019;15(1):64–74. https://doi.org/10.2174/1573403X14666181012153252.

    Article  PubMed  Google Scholar 

  29. Koshino Y, Satoh M, Katayose Y, Yasuda K, Tanigawa T, Takeyasu N, et al. Association of sleep-disordered breathing and ventricular arrhythmias in patients without heart failure. Am J Cardiol. 2008;101(6):882–6. https://doi.org/10.1016/j.amjcard.2007.10.056.

    Article  PubMed  Google Scholar 

  30. Mehra R, Benjamin EJ, Shahar E, Gottlieb DJ, Nawabit R, Kirchner HL, et al. Association of nocturnal arrhythmias with sleep-disordered breathing: the sleep heart health study. Am J Respir Crit Care Med. 2006;173(8):910–6. https://doi.org/10.1164/rccm.200509-1442OC.

    Article  PubMed  PubMed Central  Google Scholar 

  31. Koshino Y, Satoh M, Katayose Y, Kuroki K, Sekiguchi Y, Yamasaki H, et al. Sleep apnea and ventricular arrhythmias: clinical outcome, electrophysiologic characteristics, and follow-up after catheter ablation. J Cardiol. 2010;55(2):211–6. https://doi.org/10.1016/j.jjcc.2009.10.010.

    Article  PubMed  Google Scholar 

  32. Seyis S, Usalan AK, Rencuzogullari I, Kurmus O, Gungen AC. The effects of continuous positive airway pressure on premature ventricular contractions and ventricular wall stress in patients with heart failure and sleep apnea. Can Respir J. 2018;2018:2027061–8. https://doi.org/10.1155/2018/2027061.

    Article  PubMed  PubMed Central  Google Scholar 

  33. •• Priori SG, Blomstrom-Lundqvist C, Mazzanti A, Blom N, Borggrefe M, Camm J, et al. 2015 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: the task force for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death of the European Society of Cardiology (ESC). Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC). Eur Heart J. 2015;36(41):2793–867. https://doi.org/10.1093/eurheartj/ehv316. European guidline document on the management of ventricualr arrhythmias, last updated in 2015.

    Article  PubMed  Google Scholar 

  34. Lloyd-Jones DM, Wilson PW, Larson MG, Beiser A, Leip EP, D'Agostino RB, et al. Framingham risk score and prediction of lifetime risk for coronary heart disease. Am J Cardiol. 2004;94(1):20–4. https://doi.org/10.1016/j.amjcard.2004.03.023.

    Article  PubMed  Google Scholar 

  35. Fredholm BB. On the mechanism of action of theophylline and caffeine. Acta Med Scand. 1985;217(2):149–53.

    Article  CAS  Google Scholar 

  36. Zuchinali P, Ribeiro PA, Pimentel M, da Rosa PR, Zimerman LI, Rohde LE. Effect of caffeine on ventricular arrhythmia: a systematic review and meta-analysis of experimental and clinical studies. Europace. 2016;18(2):257–66. https://doi.org/10.1093/europace/euv261.

    Article  PubMed  Google Scholar 

  37. Dixit S, Stein PK, Dewland TA, Dukes JW, Vittinghoff E, Heckbert SR et al. Consumption of caffeinated products and cardiac ectopy. J Am Heart Assoc. 2016;5(1). doi:https://doi.org/10.1161/JAHA.115.002503.

  38. Tsuji H, Venditti FJ Jr, Evans JC, Larson MG, Levy D. The associations of levels of serum potassium and magnesium with ventricular premature complexes (the Framingham Heart study). Am J Cardiol. 1994;74(3):232–5.

    Article  CAS  Google Scholar 

  39. Nielsen BL, Jorgensen FS. Propranolol (Inderal) in cardiac arrhythmias. Acta Med Scand. 1966;180(5):631–8.

    Article  CAS  Google Scholar 

  40. Senior R, Muller-Beckmann B, DasGupta P, van der Does R, Lahiri A. Effects of carvedilol on ventricular arrhythmias. J Cardiovasc Pharmacol. 1992;19(Suppl 1):S117–21.

    Article  Google Scholar 

  41. Krittayaphong R, Bhuripanyo K, Punlee K, Kangkagate C, Chaithiraphan S. Effect of atenolol on symptomatic ventricular arrhythmia without structural heart disease: a randomized placebo-controlled study. Am Heart J. 2002;144(6):e10–5. https://doi.org/10.1067/mhj.2002.125516.

    Article  CAS  PubMed  Google Scholar 

  42. Hamon D, Swid MA, Rajendran PS, Liu A, Boyle NG, Shivkumar K, et al. Premature ventricular contraction diurnal profiles predict distinct clinical characteristics and beta-blocker responses. J Cardiovasc Electrophysiol. 2019. https://doi.org/10.1111/jce.13944.

    Article  Google Scholar 

  43. Yancy CW, Jessup M, Bozkurt B, Butler J, Casey DE Jr, Colvin MM, et al. 2017 ACC/AHA/HFSA focused update of the 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology/American Heart Association task force on clinical practice guidelines and the Heart Failure Society of America. J Am Coll Cardiol. 2017;70(6):776–803. https://doi.org/10.1016/j.jacc.2017.04.025.

    Article  PubMed  Google Scholar 

  44. Stec S, Sikorska A, Zaborska B, Krynski T, Szymot J, Kulakowski P. Benign symptomatic premature ventricular complexes: short- and long-term efficacy of antiarrhythmic drugs and radiofrequency ablation. Kardiol Pol. 2012;70(4):351–8.

    PubMed  Google Scholar 

  45. • Schleifer JW, Sorajja D, Shen WK. Advances in the pharmacologic treatment of ventricular arrhythmias. Expert Opin Pharmacother. 2015;16(17):2637–51. https://doi.org/10.1517/14656566.2015.1100170. Comprehensive reivew of medical therapy of ventricular arrhythmias.

    Article  CAS  PubMed  Google Scholar 

  46. Lin FC, Finley CD, Rahimtoola SH, Wu D. Idiopathic paroxysmal ventricular tachycardia with a QRS pattern of right bundle branch block and left axis deviation: a unique clinical entity with specific properties. Am J Cardiol. 1983;52(1):95–100. https://doi.org/10.1016/0002-9149(83)90077-2.

    Article  CAS  PubMed  Google Scholar 

  47. Echt DS, Liebson PR, Mitchell LB, Peters RW, Obias-Manno D, Barker AH, et al. Mortality and morbidity in patients receiving encainide, flecainide, or placebo. The cardiac arrhythmia suppression trial. N Engl J Med. 1991;324(12):781–8. https://doi.org/10.1056/NEJM199103213241201.

    Article  CAS  PubMed  Google Scholar 

  48. Cardiac Arrhythmia Suppression Trial III. Effect of the antiarrhythmic agent moricizine on survival after myocardial infarction. N Engl J Med. 1992;327(4):227–33. https://doi.org/10.1056/NEJM199207233270403.

    Article  Google Scholar 

  49. Mitchell LB, Wyse DG, Gillis AM, Duff HJ. Electropharmacology of amiodarone therapy initiation. Time courses of onset of electrophysiologic and antiarrhythmic effects. Circulation. 1989;80(1):34–42.

    Article  CAS  Google Scholar 

  50. Cairns JA, Connolly SJ, Roberts R, Gent M. Randomised trial of outcome after myocardial infarction in patients with frequent or repetitive ventricular premature depolarisations: CAMIAT. Canadian amiodarone myocardial infarction arrhythmia trial investigators. Lancet. 1997;349(9053):675–82.

    Article  CAS  Google Scholar 

  51. Brown HC, Carruthers SG, Kelly JG, McDevitt DG, Shanks RG. Observations on the efficacy and pharmacokinetics of sotalol after oral administration. Eur J Clin Pharmacol. 1976;09(5–6):367–72.

    Article  CAS  Google Scholar 

  52. Anastasiou-Nana MI, Gilbert EM, Miller RH, Singh S, Freedman RA, Keefe DL, et al. Usefulness of d, I sotalol for suppression of chronic ventricular arrhythmias. Am J Cardiol. 1991;67(6):511–6.

    Article  CAS  Google Scholar 

  53. Giorgi C, Nadeau R, Agha A, Primeau R, de Champlain J. Efficacy of oral sotalol in suppression of premature ventricular complexes and analysis of its beta-adrenergic blocking activity. Can J Cardiol. 1990;6(5):191–7.

    CAS  PubMed  Google Scholar 

  54. Cronin EM, Bogun FM, Maury P, Peichl P, Chen M, Namboodiri N, et al. 2019 HRS/EHRA/APHRS/LAHRS expert consensus statement on catheter ablation of ventricular arrhythmias. Heart Rhythm. 2019. https://doi.org/10.1016/j.hrthm.2019.03.002. Recent updated guidelines on the use of ablation for ventricular arrhythmias.

  55. Yamada T, McElderry HT, Doppalapudi H, Kay GN. Catheter ablation of ventricular arrhythmias originating in the vicinity of the His bundle: significance of mapping the aortic sinus cusp. Heart Rhythm. 2008;5(1):37–42. https://doi.org/10.1016/j.hrthm.2007.08.032.

    Article  PubMed  Google Scholar 

  56. Dixit S, Gerstenfeld EP, Lin D, Callans DJ, Hsia HH, Nayak HM, et al. Identification of distinct electrocardiographic patterns from the basal left ventricle: distinguishing medial and lateral sites of origin in patients with idiopathic ventricular tachycardia. Heart Rhythm. 2005;2(5):485–91. https://doi.org/10.1016/j.hrthm.2005.01.023.

    Article  PubMed  Google Scholar 

  57. Wang Y, Cuculich PS, Zhang J, Desouza KA, Vijayakumar R, Chen J, et al. Noninvasive electroanatomic mapping of human ventricular arrhythmias with electrocardiographic imaging. Sci Transl Med. 2011;3(98):98ra84. https://doi.org/10.1126/scitranslmed.3002152.

    Article  PubMed  PubMed Central  Google Scholar 

  58. •• Mahida S, Sacher F, Dubois R, Sermesant M, Bogun F, Haissaguerre M, et al. Cardiac imaging in patients with ventricular tachycardia. Circulation. 2017;136(25):2491–507. https://doi.org/10.1161/CIRCULATIONAHA.117.029349. Comprehensive reivew of cardiac imaging and its role in evaluating ventricular tachycardia.

    Article  PubMed  Google Scholar 

  59. Ariga R, Tunnicliffe EM, Manohar SG, Mahmod M, Raman B, Piechnik SK, et al. Identification of myocardial disarray in patients with hypertrophic cardiomyopathy and ventricular arrhythmias. J Am Coll Cardiol. 2019;73(20):2493–502. https://doi.org/10.1016/j.jacc.2019.02.065.

    Article  PubMed  PubMed Central  Google Scholar 

  60. Ghannam M, Cochet H, Jais P, Sermesant M, Patel S, Siontis KC, et al. Correlation between computer tomography-derived scar topography and critical ablation sites in postinfarction ventricular tachycardia. J Cardiovasc Electrophysiol. 2018;29(3):438–45. https://doi.org/10.1111/jce.13441.

    Article  PubMed  Google Scholar 

  61. Nazer B, Woods C, Dewland T, Moyers B, Badhwar N, Gerstenfeld EP. Importance of ventricular tachycardia induction and mapping for patients referred for epicardial ablation. Pacing Clin Electrophysiol. 2015;38(11):1333–42. https://doi.org/10.1111/pace.12703.

    Article  PubMed  Google Scholar 

  62. Sarrazin JF, Good E, Kuhne M, Oral H, Pelosi F Jr, Chugh A, et al. Mapping and ablation of frequent post-infarction premature ventricular complexes. J Cardiovasc Electrophysiol. 2010;21(9):1002–8. https://doi.org/10.1111/j.1540-8167.2010.01771.x.

    Article  PubMed  Google Scholar 

  63. Kurosaki K, Nogami A, Sakamaki M, Kowase S, Sugiyasu A, Oginosawa Y, et al. Automated template matching to pinpoint the origin of right ventricular outflow tract tachycardia. Pacing Clin Electrophysiol. 2009;32(Suppl 1):S47–51. https://doi.org/10.1111/j.1540-8159.2008.02226.x.

    Article  PubMed  Google Scholar 

  64. Nogami A, Tada H. Ablation of idiopathic left and right ventricular and fascicular tachycardias. In: Huang SKS, Miller J, editors. Catheter ablation of cardiac arrhythmias. 4th edition. ed. Philadelphia: Elsevier; 2019. p. 467–509.

    Google Scholar 

  65. Yamada T, Kay G. Complications associated with radiofrequency catheter ablation of arrythmias. In: Huang SKS, Miller J, editors. Catheter ablation of cardiac arrhythmias. 4th edition. ed. Philadelphia: Elsevier; 2019. p. 636–47.

    Google Scholar 

  66. Tanaka A, Takemoto M, Masumoto A, Kang H, Mito T, Kumeda H, et al. Radiofrequency catheter ablation of premature ventricular contractions from near the His-bundle. J Arrhythm. 2019;35(2):252–61. https://doi.org/10.1002/joa3.12167.

    Article  PubMed  PubMed Central  Google Scholar 

  67. Santangeli P, Di Biase L, Natale A. Ablation versus drugs: what is the best first-line therapy for paroxysmal atrial fibrillation? Antiarrhythmic drugs are outmoded and catheter ablation should be the first-line option for all patients with paroxysmal atrial fibrillation: pro. Circ Arrhythm Electrophysiol. 2014;7(4):739–46. https://doi.org/10.1161/CIRCEP.113.000629.

    Article  PubMed  Google Scholar 

  68. Huang CX, Liang JJ, Yang B, Jiang H, Tang QZ, Liu XJ, et al. Quality of life and cost for patients with premature ventricular contractions by radiofrequency catheter ablation. Pacing Clin Electrophysiol. 2006;29(4):343–50. https://doi.org/10.1111/j.1540-8159.2006.00351.x.

    Article  PubMed  Google Scholar 

  69. Armaganijan LV, Staico R, Moreira DA, Lopes RD, Medeiros PT, Habib R, et al. 6-month outcomes in patients with implantable cardioverter-defibrillators undergoing renal sympathetic denervation for the treatment of refractory ventricular arrhythmias. JACC Cardiovasc Interv. 2015;8(7):984–90. https://doi.org/10.1016/j.jcin.2015.03.012.

    Article  PubMed  Google Scholar 

  70. Kiuchi MG, Vitorio FP, da Silva GR, Paz LM, Souto GL. A case report of renal sympathetic denervation for the treatment of polymorphic ventricular premature complexes: expanding horizons. Medicine (Baltimore). 2015;94(50):e2287. https://doi.org/10.1097/MD.0000000000002287.

    Article  Google Scholar 

  71. Robinson CG, Samson PP, Moore KMS, Hugo GD, Knutson N, Mutic S, et al. Phase I/II trial of electrophysiology-guided noninvasive cardiac radioablation for ventricular tachycardia. Circulation. 2019;139(3):313–21. https://doi.org/10.1161/CIRCULATIONAHA.118.038261.

    Article  PubMed  Google Scholar 

  72. Cuculich PS, Schill MR, Kashani R, Mutic S, Lang A, Cooper D, et al. Noninvasive cardiac radiation for ablation of ventricular tachycardia. N Engl J Med. 2017;377(24):2325–36. https://doi.org/10.1056/NEJMoa1613773.

    Article  PubMed  PubMed Central  Google Scholar 

  73. Loo BW Jr, Soltys SG, Wang L, Lo A, Fahimian BP, Iagaru A, et al. Stereotactic ablative radiotherapy for the treatment of refractory cardiac ventricular arrhythmia. Circ Arrhythm Electrophysiol. 2015;8(3):748–50. https://doi.org/10.1161/CIRCEP.115.002765.

    Article  PubMed  Google Scholar 

  74. Maor E, Sugrue A, Witt C, Vaidya VR, DeSimone CV, Asirvatham SJ, et al. Pulsed electric fields for cardiac ablation and beyond: a state-of-the-art review. Heart Rhythm. 2019;16:1112–20. https://doi.org/10.1016/j.hrthm.2019.01.012.

    Article  PubMed  Google Scholar 

  75. Reddy VY, Koruth J, Jais P, Petru J, Timko F, Skalsky I, et al. Ablation of atrial fibrillation with pulsed electric fields: an ultra-rapid, tissue-selective modality for cardiac ablation. JACC Clin Electrophysiol. 2018;4(8):987–95. https://doi.org/10.1016/j.jacep.2018.04.005.

    Article  PubMed  Google Scholar 

  76. Stevenson WG, Tedrow UB, Reddy V, AbdelWahab A, Dukkipati S, John RM, et al. Infusion needle radiofrequency ablation for treatment of refractory ventricular arrhythmias. J Am Coll Cardiol. 2019;73(12):1413–25. https://doi.org/10.1016/j.jacc.2018.12.070.

    Article  PubMed  Google Scholar 

  77. Sapp JL, Cooper JM, Soejima K, Sorrell T, Lopera G, Satti SD, et al. Deep myocardial ablation lesions can be created with a retractable needle-tipped catheter. Pacing Clin Electrophysiol. 2004;27(5):594–9. https://doi.org/10.1111/j.1540-8159.2004.00492.x.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Prabhat Kumar MD.

Ethics declarations

Conflict of Interest

Michael P. O’Quinn, Anthony J. Mazzella, and Prabhat Kumar each declare no potential conflicts of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This article is part of the Topical Collection on Arrhythmia

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

O’Quinn, M.P., Mazzella, A.J. & Kumar, P. Approach to Management of Premature Ventricular Contractions. Curr Treat Options Cardio Med 21, 53 (2019). https://doi.org/10.1007/s11936-019-0755-y

Download citation

  • Published:

  • DOI: https://doi.org/10.1007/s11936-019-0755-y

Keywords

Navigation