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Production of Urothelium from Pluripotent Stem Cells for Regenerative Applications

  • Regenerative Medicine (A Atala, Section Editor)
  • Published:
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Abstract

As bladder reconstruction strategies evolve, a feasible and safe source of transplantable urothelium becomes a major consideration for patients with advanced bladder disease, particularly cancer. Pluripotent stem cells, such as embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), are attractive candidates from which to derive urothelium as they renew and proliferate indefinitely in vitro and fulfill the non-autologous and/or non-urologic criteria, respectively, that is required for many patients. This review presents the latest advancements in differentiating urothelium from pluripotent stem cells in vitro in the context of current bladder tissue engineering strategies.

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Conflict of Interest

Dr. Stephanie L. Osborn and Dr. Eric A. Kurzrock each declare no potential conflicts of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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Authors and Affiliations

  1. Department of Urology, University of California, Davis School of Medicine, 4860 Y Street, Suite 3500, Sacramento, CA, 95817, USA

    Stephanie L. Osborn & Eric A. Kurzrock

  2. Stem Cell Program, Institute for Regenerative Cures, University of California, Davis Medical Center, 2921 Stockton Blvd, Suite 1630, Sacramento, CA, 95817, USA

    Stephanie L. Osborn & Eric A. Kurzrock

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  1. Stephanie L. Osborn
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  2. Eric A. Kurzrock
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Correspondence to Eric A. Kurzrock.

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This article is part of the Topical Collection on Regenerative Medicine

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Osborn, S.L., Kurzrock, E.A. Production of Urothelium from Pluripotent Stem Cells for Regenerative Applications. Curr Urol Rep 16, 466 (2015). https://doi.org/10.1007/s11934-014-0466-6

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  • DOI: https://doi.org/10.1007/s11934-014-0466-6

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